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Recruiting Phase 3 Interventional

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

ClinicalTrials.gov ID: NCT05566795

Public ClinicalTrials.gov record NCT05566795. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 5:40 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients With Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

Study identification

NCT ID
NCT05566795
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Day One Biopharmaceuticals, Inc.
Industry
Enrollment
400 participants

Conditions and interventions

Interventions

  • Chemotherapeutic Agent Drug
  • Tovorafenib Drug

Drug

Eligibility (public fields only)

Age range
Up to 25 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 26, 2023
Primary completion
May 31, 2027
Completion
May 31, 2031
Last update posted
Mar 1, 2026

2023 – 2031

United States locations

U.S. sites
38
U.S. states
26
U.S. cities
36
Facility City State ZIP Site status
Children's of Alabama Birmingham Alabama 35233 Recruiting
Phoenix Children's Hospital Phoenix Arizona 85016 Recruiting
Children's Hospital Los Angeles Los Angeles California 90027 Recruiting
Children's Hospital of Orange County Main Campus - Orange Orange California 92868 Recruiting
Packard Children's Hospital Stanford Palo Alto California 94304 Recruiting
UCSF Benioff Children's Hospital San Francisco California 94158 Recruiting
Children's Hospital Colorado Aurora Colorado 80045 Recruiting
Connecticut Children's Medical Center Hartford Connecticut 06106-3322 Recruiting
Children's National Medical Center Washington D.C. District of Columbia 20010 Recruiting
University of Florida Health Gainesville Florida 32610 Recruiting
Nicklaus Children's Hospital Miami Florida 33155 Recruiting
Arnold Palmer Hospital for Children Orlando Florida 32806 Recruiting
Johns Hopkins All Children's Hospital St. Petersburg Florida 33701 Recruiting
Children's Healthcare of Atlanta Atlanta Georgia 30322 Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois 60611 Recruiting
University of Chicago Chicago Illinois 60637 Recruiting
Riley Hospital for Children at Indiana University Health Indianapolis Indiana 46202 Recruiting
University of Iowa Hospitals Clinics Iowa City Iowa 52242 Recruiting
Norton Children's Hospital Louisville Kentucky 40202 Recruiting
Maine Children's Cancer Program Scarborough Maine 04074 Recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Recruiting
University of Michigan - - C.S. Mott Children's Hospital Ann Arbor Michigan 48109 Recruiting
Children's Minnesota Minneapolis Minnesota 55404 Recruiting
Childrens MS Cncr Ctr Bld Dsr Jackson Mississippi 39216 Recruiting
St. Louis Children's Hospital St Louis Missouri 63110 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198-6878 Recruiting
Albany Medical Center Albany New York 12208 Recruiting
New York University Langone Health New York New York 10016 Recruiting
Columbia University New York New York 10032 Recruiting
University of Rochester Rochester New York 14642 Recruiting
Duke Cancer Institute Durham North Carolina 27705 Recruiting
Cleveland Clinic Main Campus Cleveland Ohio 44195 Recruiting
Oregon Health Science University Portland Oregon 97239 Recruiting
Dell Children's Medical Center of Central Texas Austin Texas 78723 Recruiting
University of Texas Southwestern Medical Center Dallas Texas 75390 Recruiting
Texas Children's Hospital Houston Texas 77030 Recruiting
Seattle Children's Hospital Seattle Washington 98105 Recruiting
University of Wisconsin - Madison Madison Wisconsin 53792 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 100 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05566795, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 1, 2026 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05566795 live on ClinicalTrials.gov.

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