A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/Ritonavir
Public ClinicalTrials.gov record NCT05567952. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN INTERVENTIONAL, EFFICACY AND SAFETY, PHASE 2, RANDOMIZED, DOUBLE-BLIND, 2-ARM STUDY TO INVESTIGATE A REPEAT 5-DAY COURSE OF NIRMATRELVIR/RITONAVIR COMPARED TO PLACEBO/RITONAVIR IN PARTICIPANTS AT LEAST 12 YEARS OF AGE WITH REBOUND OF COVID-19 SYMPTOMS AND RAPID ANTIGEN TEST POSITIVITY
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to learn about the safety and effects of nirmatrelvir/ritonavir for the potential treatment of COVID-19 rebound. The study is seeking participants who: * Have completed treatment with nirmatrelvir/ritonavir * Have a rebound in COVID-19 symptoms * Are SARS-CoV-2 (COVID-19) positive All study medications will be taken 2 times a day by mouth for 5 days. The first dose of study medication is taken at the study clinic and the rest at home. We will examine the experiences of people receiving the study medicines to those who do not. This will help us determine if the study medicines are safe and effective. People taking part will be in this study for about 24 weeks. Enrolled participants will need to visit the study clinic at least 8 times during the study.
Study identification
- NCT ID
- NCT05567952
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 436 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 19, 2022 (Actual)
- Primary completion
- Sep 27, 2023 (Actual)
- Completion
- Feb 9, 2024 (Actual)
- Last update posted
- Oct 8, 2024
2022 – 2024
United States locations
- U.S. sites
- 67
- U.S. states
- 22
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Institute for Liver Health dba Arizona Clinical Trials | Mesa | Arizona | 85210 | — |
| Abby's Research institute | Phoenix | Arizona | 85031 | — |
| Epic Medical Research - Surprise | Surprise | Arizona | 85378 | — |
| Smart Cures Clinical Research | Anaheim | California | 92806 | — |
| Hope Clinical Research, Inc. | Canoga Park | California | 91303 | — |
| Ascada Health PC dba Ascada Research | Fullerton | California | 92835 | — |
| Ascada Research | Fullerton | California | 92835 | — |
| Paradigm Clinical Research Centers, Inc | La Mesa | California | 91942 | — |
| CVS Health - 8876 - Long Beach | Long Beach | California | 90806 | — |
| Carbon Health - North Hollywood - NoHo West | North Hollywood | California | 91606 | — |
| Paradigm Clinical Research Centers, Inc | Wheat Ridge | Colorado | 80033 | — |
| Emerson Clinical Research Institute - Washington - Connecticut Avenue | Washington D.C. | District of Columbia | 20009 | — |
| Emerson Clinical Research Institute | Washington D.C. | District of Columbia | 20011 | — |
| Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research | Brandon | Florida | 33511 | — |
| Herco Medical and Research Center Inc | Coral Gables | Florida | 33134 | — |
| NeoClinical Research | Hialeah | Florida | 33016 | — |
| Sweet Hope Research Specialty, Inc | Hialeah | Florida | 33016 | — |
| Unlimited Medical Research Group LLC | Hialeah Gardens | Florida | 33018 | — |
| Asclepes Research Center - Spring Hill | Lutz | Florida | 33549 | — |
| LCC Medical Research Institute | Miami | Florida | 33126 | — |
| Premium Medical Research Corp | Miami | Florida | 33126 | — |
| Global Health Clinical Trials | Miami | Florida | 33135 | — |
| South Florida Research Center | Miami | Florida | 33135 | — |
| Reliant Medical Research | Miami | Florida | 33165 | — |
| Innova Pharma Research | Miami | Florida | 33175 | — |
| Entrust Clinical Research | Miami | Florida | 33176 | — |
| Reed Medical Research | Miami | Florida | 33176 | — |
| Kendall South Medical Center | Miami | Florida | 33185 | — |
| Pro-Care Research Center, Corp. | Miami Gardens | Florida | 33014 | — |
| Omega Research Orlando | Orlando | Florida | 32808 | — |
| NAPA Research | Pompano Beach | Florida | 33064 | — |
| Asclepes Research Center - Spring Hill | Spring Hill | Florida | 34609 | — |
| GCP Research, Global Clinical professionals | St. Petersburg | Florida | 33705 | — |
| Theia Clinical Research - 5th Avenue North | St. Petersburg | Florida | 33710 | — |
| Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research | Tampa | Florida | 33609 | — |
| Santos Research Center | Tampa | Florida | 33615 | — |
| Clinical Site Partners, LLC dba CSP Orlando | Winter Park | Florida | 32789 | — |
| Clinical Site Partners, LLC dba Flourish Research | Winter Park | Florida | 32789 | — |
| Bingham Memorial Hospital | Blackfoot | Idaho | 83221 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Centennial Medical Group | Elkridge | Maryland | 21075 | — |
| University of Massachusetts Chan Medical School | Worcester | Massachusetts | 01655 | — |
| Great Lakes Research Group, Inc. | Bay City | Michigan | 48706 | — |
| C.S. Mott Clinical Research Center (CRC) | Detroit | Michigan | 48201 | — |
| Beaumont Infectious Diseases Research | Royal Oak | Michigan | 48073 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| Excel Clinical Research, LLC | Las Vegas | Nevada | 89109 | — |
| CVS Health - Site 02815 East Brunswick | East Brunswick | New Jersey | 08816 | — |
| Hackensack Meridian Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Onsite Clinical Solutions (secondary location) | Charlotte | North Carolina | 28208 | — |
| OnSite Clinical Solutions | Charlotte | North Carolina | 28208 | — |
| Accellacare - Wilmington | Wilmington | North Carolina | 28401 | — |
| WellNow Urgent Care and Research - Columbus | Columbus | Ohio | 43214 | — |
| Willamette Valley Clinical Studies | Eugene | Oregon | 97404 | — |
| Heritage Valley Multispecialty Group, Inc | Beaver | Pennsylvania | 15009 | — |
| Premier Primary Care | Union City | Tennessee | 38261 | — |
| Nayak Research, LLC | Andrews | Texas | 79714 | — |
| Headlands Research - Brownsville | Brownsville | Texas | 78526 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| Next Innovative Clinical Research | Houston | Texas | 77021 | — |
| Next Level Urgent Care | Houston | Texas | 77057 | — |
| Accurate Clinical Research - East Humble | Humble | Texas | 77338 | — |
| Accurate Clinical Research, Inc | Humble | Texas | 77338 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Eastside Research Associates | Redmond | Washington | 98052 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05567952, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2024 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05567952 live on ClinicalTrials.gov.