Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia
Public ClinicalTrials.gov record NCT05568654. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care
Study identification
- NCT ID
- NCT05568654
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 28,580 participants
Conditions and interventions
Interventions
- Rapid Diagnostic Testing Diagnostic Test
- Pharmacist-led de-escalation Other
Diagnostic Test · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 31, 2022
- Primary completion
- Jan 30, 2026
- Completion
- Jun 29, 2026
- Last update posted
- Jun 30, 2026
2022 – 2026
United States locations
- U.S. sites
- 12
- U.S. states
- 2
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Indian River Hospital | Vero Beach | Florida | 32960 | — |
| Weston Hospital/Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Akron General Hospital | Akron | Ohio | 44307 | — |
| Avon Hospital | Avon | Ohio | 44011 | — |
| Lutheran Hospital | Cleveland | Ohio | 44113 | — |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | — |
| Euclid Hospital | Euclid | Ohio | 44119 | — |
| Fairview Hospital | Fairview Park | Ohio | 44111 | — |
| Marymount Hospital | Garfield Heights | Ohio | 44125 | — |
| Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | — |
| Medina Hospital | Medina | Ohio | 44256 | — |
| South Pointe Hospital | Warrensville Heights | Ohio | 44122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05568654, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 30, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05568654 live on ClinicalTrials.gov.