ClinicalTrials.gov record
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
ClinicalTrials.gov ID: NCT05581303
Public ClinicalTrials.gov record NCT05581303. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 29, 2026, 9:03 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a)
Study identification
- NCT ID
- NCT05581303
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Amgen
- Industry
- Enrollment
- 7,297 participants
Conditions and interventions
Conditions
Interventions
- Olpasiran Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2022
- Primary completion
- Mar 30, 2028
- Completion
- Mar 30, 2028
- Last update posted
- Feb 26, 2026
2022 – 2028
United States locations
- U.S. sites
- 133
- U.S. states
- 38
- U.S. cities
- 115
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ascension Saint Vincents Birmingham | Birmingham | Alabama | 35211 | — |
| Grandview Medical Center Affinity Cardiovascular Specialists, LLC | Birmingham | Alabama | 35243 | — |
| Heart Center Research LLC | Huntsville | Alabama | 35801 | — |
| Mobile Heart Specialists PC | Mobile | Alabama | 36608 | — |
| Alaska Cardiovascular Research Foundation | Anchorage | Alaska | 99508 | — |
| Elite Clinical Studies LLC | Phoenix | Arizona | 85018 | — |
| HonorHealth Research and Innovation Institute | Scottsdale | Arizona | 85258 | — |
| National Heart Institute | Beverly Hills | California | 90211 | — |
| Vitality Clinical Research | Beverly Hills | California | 90211 | — |
| University of California San Diego | La Jolla | California | 92037 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California Irvine | Orange | California | 92868 | — |
| University of California Los Angeles | Santa Monica | California | 90404 | — |
| Manshadi Heart Institute | Stockton | California | 95204 | — |
| Med Partners, Inc dba Premiere Medical Center, Inc | Toluca Lake | California | 91602 | — |
| UCHealth Memorial Central | Colorado Springs | Colorado | 80909 | — |
| Cardiology Associates of Fairfield County PC | Stamford | Connecticut | 06905 | — |
| MedStar Clinical Research | Washington D.C. | District of Columbia | 20010 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Bay Area Cardiology | Brandon | Florida | 33511 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Cardiology Associates Research LLC | Daytona Beach | Florida | 32117 | — |
| Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| Elite Cardiac Research Center LLC | Hialeah | Florida | 33013 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32204 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| University of Florida | Jacksonville | Florida | 32209 | — |
| East Coast Institute for Research LLC | Jacksonville | Florida | 32216 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Advanced Research for Health Improvement, LLC | Naples | Florida | 34102 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| AdventHealth Medical Group Cardiology at Orlando | Orlando | Florida | 32803 | — |
| East Coast Institute for Research, LLC | Saint Augustine | Florida | 32086 | — |
| Saint Johns Center for Clinical Research | Saint Augustine | Florida | 32086 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| Care Access - Tampa | Tampa | Florida | 33625 | — |
| Piedmont Healthcare | Atlanta | Georgia | 30309 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Northeast Georgia Medical Center Wisteria Building | Cumming | Georgia | 30041 | — |
| NSC Research | Johns Creek | Georgia | 30024 | — |
| St Lukes Idaho Cardiology Associates | Meridian | Idaho | 83642 | — |
| Northwest Heart Clinical Research LLC | Arlington Heights | Illinois | 60005 | — |
| Northshore University Health System | Evanston | Illinois | 60201 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Cardiovascular Research of Northwest Indiana LLC | Munster | Indiana | 46321 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| MercyOne Iowa Heart Center | West Des Moines | Iowa | 50266 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Midwest Heart and Vascular Specialists | Overland Park | Kansas | 66211 | — |
| Saint Elizabeth Covington | Covington | Kentucky | 41011 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| University of Louisville Health - Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Louisiana Heart Center | Hammond | Louisiana | 70403 | — |
| Care Access - Lake Charles | Lake Charles | Louisiana | 70601 | — |
| Clinical Trials of America Inc | Monroe | Louisiana | 71201 | — |
| Monroe Research LLC | West Monroe | Louisiana | 71291 | — |
| Northern Light Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21287 | — |
| Metropolitan Cardiovascular Consultants LLC | Beltsville | Maryland | 20705 | — |
| TidalHealth Peninsula Regional, Inc | Salisbury | Maryland | 21804 | — |
| Brigham and Womens Hospital | Boston | Massachusetts | 02115 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Ascension Saint John Hospital | Detroit | Michigan | 48236 | — |
| Advanced Cardiology Associates | Grand Rapids | Michigan | 49546 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| Fairview Health Services | Maplewood | Minnesota | 55109 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55902 | — |
| Cardiology Associates Research LLC | Tupelo | Mississippi | 38801 | — |
| Saint Louis Heart and Vascular PC | St Louis | Missouri | 63136 | — |
| Bryan Heart | Lincoln | Nebraska | 68506 | — |
| Palm Research Center Inc | Las Vegas | Nevada | 89128 | — |
| Renown Institute for Heart and Vascular Health | Reno | Nevada | 89502 | — |
| Saint Michaels Medical Center | Newark | New Jersey | 07102 | — |
| Overlook Medical Center | Summit | New Jersey | 91010 | — |
| New York Presbyterian Medical Group Hudson Valley Cardiology | Cortlandt Manor | New York | 10567 | — |
| Elligo Health Research | Kew Gardens | New York | 11415 | — |
| WMCHealth Heart and Vascular Institute Kingston Division of Cardiology | Kingston | New York | 12401 | — |
| Northwell Health Physician Partners Cardiology at Manhasset | Manhasset | New York | 11030 | — |
| New York University Langone Health | New York | New York | 10016 | — |
| Northwell Health Lenox Hill Heart and Vascular | New York | New York | 10022 | — |
| Icahn School of Medicine at Mount Sinai Queens | New York | New York | 10029 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Northwell Health Physician Partners at Peconic | Riverhead | New York | 11901 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| NY Family Docs | Woodhaven | New York | 11421 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Moses H Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Lapis Clinical Research | Mooresville | North Carolina | 28117 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| TriHealth Good Samaritan Hospital | Cincinnati | Ohio | 45220 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| The OhioHealth Research Institute | Columbus | Ohio | 43214 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Capital Area Research LLC | Newport | Pennsylvania | 17074 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Montefiore Medical Center - Bronx | Philadelphia | Pennsylvania | 19141 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health Midlands Cardiology | Columbia | South Carolina | 29203 | — |
| Piedmont Research Partners | Fort Mill | South Carolina | 29707 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Stern Cardiovascular Foundation Inc | Germantown | Tennessee | 38138 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Texas Diabetes and Endocrinology | Austin | Texas | 78731 | — |
| Baylor Scott and White Heart and Vascular Hospital-Dallas | Dallas | Texas | 75226 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| David Turbay, MD | El Paso | Texas | 79905 | — |
| Care Access - Georgetown | Georgetown | Texas | 78633 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Texas Cardiology Associates of Houston | Kingwood | Texas | 77339 | — |
| Texas Institute of Cardiology | McKinney | Texas | 75071 | — |
| Permian Research Foundation | Odessa | Texas | 79761 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Inova Heart and Vascular Institute | Fairfax | Virginia | 22031 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Virginia Heart - Loudoun | Leesburg | Virginia | 20176 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Bon Secours Cardiology | Midlothian | Virginia | 23114 | — |
| Tidewater Physicians Multispecialty Group Clinical Research | Newport News | Virginia | 23606 | — |
| Winchester Cardiology and Vascular Medicine | Winchester | Virginia | 22601 | — |
| Pulse Heart Institute | Puyallup | Washington | 98372 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 604 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05581303, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 26, 2026 · Synced Apr 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05581303 live on ClinicalTrials.gov.