A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy
Public ClinicalTrials.gov record NCT05582395. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate Mavacamten in Adults With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety, tolerability, and efficacy of mavacamten compared with placebo in participants with symptomatic non-obstructive hypertrophic cardiomyopathy (nHCM).
Study identification
- NCT ID
- NCT05582395
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 580 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2022 (Actual)
- Primary completion
- Mar 6, 2025 (Actual)
- Completion
- Oct 20, 2025 (Actual)
- Last update posted
- Sep 18, 2026
2022 – 2025
United States locations
- U.S. sites
- 41
- U.S. states
- 24
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0082 | Birmingham | Alabama | 35233-1900 | — |
| Local Institution - 0458 | Phoenix | Arizona | 85054 | — |
| Local Institution - 0409 | La Jolla | California | 92037-1337 | — |
| Local Institution - 0010 | Los Angeles | California | 90048-3311 | — |
| Local Institution - 0406 | San Francisco | California | 94143-2204 | — |
| Local Institution - 0079 | Stanford | California | 94305-2200 | — |
| Local Institution - 0468 | Gainesville | Florida | 32608-1134 | — |
| Local Institution - 0281 | Tampa | Florida | 33606-3603 | — |
| Local Institution - 0092 | Atlanta | Georgia | 30322 | — |
| Local Institution - 0424 | Indianapolis | Indiana | 46202-1243 | — |
| Local Institution - 0070 | Iowa City | Iowa | 52242-1009 | — |
| Local Institution - 0410 | Kansas City | Kansas | 66160-8500 | — |
| Local Institution - 0484 | Louisville | Kentucky | 40217-1363 | — |
| Local Institution - 0127 | Baltimore | Maryland | 21287 | — |
| Local Institution - 0479 | Boston | Massachusetts | 02114 | — |
| Local Institution - 0500 | Boston | Massachusetts | 02118-2908 | — |
| Local Institution - 0464 | Ann Arbor | Michigan | 48109 | — |
| Local Institution - 0064 | Detroit | Michigan | 48202-2608 | — |
| Local Institution - 0455 | Grand Rapids | Michigan | 49525 | — |
| Local Institution - 0431 | Rochester | Minnesota | 55905 | — |
| Local Institution - 0461 | St Louis | Missouri | 63110 | — |
| Local Institution - 0435 | Omaha | Nebraska | 68198-2265 | — |
| Local Institution - 0490 | Morristown | New Jersey | 07962 | — |
| Local Institution - 0449 | Manhasset | New York | 11030-3816 | — |
| Local Institution - 0486 | New York | New York | 10019-1147 | — |
| Local Institution - 0007 | Stony Brook | New York | 11790-3407 | — |
| Local Institution - 0426 | Valhalla | New York | 10595 | — |
| Local Institution - 0094 | Charlotte | North Carolina | 28204-2826 | — |
| Local Institution - 0065 | Durham | North Carolina | 27710 | — |
| Local Institution - 0083 | Cleveland | Ohio | 44195 | — |
| Local Institution - 0047 | Hershey | Pennsylvania | 17033 | — |
| Local Institution - 0444 | Lancaster | Pennsylvania | 17602-2250 | — |
| Local Institution - 0263 | Philadelphia | Pennsylvania | 19104 | — |
| Local Institution - 0081 | Pittsburgh | Pennsylvania | 15213-2536 | — |
| Local Institution - 0207 | Germantown | Tennessee | 38138-1727 | — |
| Local Institution - 0089 | Dallas | Texas | 75246 | — |
| Local Institution - 0365 | Dallas | Texas | 75390 | — |
| Local Institution - 0492 | Plano | Texas | 75093 | — |
| Local Institution - 0402 | Salt Lake City | Utah | 84132-0001 | — |
| Local Institution - 0478 | Charlottesville | Virginia | 22908-0001 | — |
| Local Institution - 0095 | Richmond | Virginia | 23298-5024 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 183 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05582395, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05582395 live on ClinicalTrials.gov.