Study of Novel Antiretrovirals in Participants With HIV-1
Public ClinicalTrials.gov record NCT05585307. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Umbrella Phase 1b, Open-label, Multi-Cohort Study to Evaluate Safety, Pharmacokinetics, and Antiviral Activity of Novel Antiretrovirals in Participants With HIV-1
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Master protocol: The goal of this master clinical trial study is to learn how novel antiretrovirals (medicines that stop the virus from multiplying) affect the human immunodeficiency virus-1 (HIV-1) infection in people living with HIV (PWH). Substudy-01 (GS-US-544-5905-01) will evaluate bavtavirine in PWH. Substudy-02 (GS-US-544-5905-02) will evaluate GS-1720 in PWH. Substudy-03 (GS-US-544-5905-03) will evaluate GS-6212 in PWH.
Study identification
- NCT ID
- NCT05585307
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 49 participants
Conditions and interventions
Conditions
Interventions
- Bavtavirine Drug
- B/F/TAF Drug
- Standard of Care (Substudy 01) Drug
- GS-1720 Drug
- Standard of Care (Substudy 02) Drug
- GS-6212 Drug
- Standard of Care (Substudy 03) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2022
- Primary completion
- Feb 16, 2024
- Completion
- Mar 17, 2024
- Last update posted
- May 7, 2025
2022 – 2024
United States locations
- U.S. sites
- 38
- U.S. states
- 9
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Long Beach Education and Research Consultants,Substudy-03 | Long Beach | California | 90813 | — |
| Mills Clinical Research,Substudy-02 | Los Angeles | California | 90069 | — |
| Mills Clinical Research,Substudy-03 | Los Angeles | California | 90069 | — |
| Quest Clinical Research,Substudy-01 | San Francisco | California | 94115 | — |
| Quest Clinical Research,Substudy-02 | San Francisco | California | 94115 | — |
| Quest Clinical Research,Substudy-03 | San Francisco | California | 94115 | — |
| Yale University; School of Medicine; AIDS Program (Administrative & Study Supplies),Substudy-03 | New Haven | Connecticut | 06510 | — |
| Yale University,Substudy-02 | New Haven | Connecticut | 06520 | — |
| Washington Health Institute,Substudy-01 | Washington D.C. | District of Columbia | 20017 | — |
| Washington Health Institute,Substudy-02 | Washington D.C. | District of Columbia | 20017 | — |
| Washington Health Institute,Substudy-03 | Washington D.C. | District of Columbia | 20017 | — |
| Midland Florida Clinical Research Center, LLC,Substudy-02 | DeLand | Florida | 32720 | — |
| Midland Florida Clinical Research, LLC,Substudy-03 | DeLand | Florida | 32720 | — |
| Midway Immunology and Research Center,Substudy-01 | Ft. Pierce | Florida | 34982 | — |
| Midway Immunology and Research Center,Substudy-02 | Ft. Pierce | Florida | 34982 | — |
| Midway Immunology and Research Center,Substudy-03 | Ft. Pierce | Florida | 34982 | — |
| Bliss Health,Substudy-02 | Orlando | Florida | 32803 | — |
| Bliss Health,Substudy-03 | Orlando | Florida | 32803 | — |
| Orlando Immunology Center,Substudy-01 | Orlando | Florida | 32803 | — |
| Orlando Immunology Center,Substudy-03 | Orlando | Florida | 32803 | — |
| Triple O Research Institute, P.A.,Substudy-01 | West Palm Beach | Florida | 33407 | — |
| Triple O Research Institute, P.A.,Substudy-03 | West Palm Beach | Florida | 33407 | — |
| Infectious Disease Specialists of Atlanta,Substudy-01 | Decatur | Georgia | 30033 | — |
| Indiana CTSI Clinical Research Center,Substudy-01 | Indianapolis | Indiana | 46202 | — |
| University of Cincinnati College of Medicine,Substudy-02 | Cincinnati | Ohio | 45267 | — |
| University of Cincinnati College of Medicine,Substudy-03 | Cincinnati | Ohio | 45267 | — |
| Central Texas Clinical Research,Substudy-01 | Austin | Texas | 78705 | — |
| Central Texas Clinical Research,Substudy-03 | Austin | Texas | 78705 | — |
| Prism Health North Texas,Substudy-02 | Dallas | Texas | 75208 | — |
| Prism Health North Texas,Substudy-03 | Dallas | Texas | 75215 | — |
| North Texas Infectious Diseases Consultant, P.A.,Substudy-02 | Dallas | Texas | 75246 | — |
| North Texas Infectious Diseases Consultants, P.A.,Substudy-03 | Dallas | Texas | 75246 | — |
| AXCES Research,Substudy-02 | El Paso | Texas | 79902 | — |
| AXES Research Group LLC,Substudy-03 | El Paso | Texas | 79902 | — |
| Therapeutic Concepts, PA,Substudy-02 | Houston | Texas | 77004 | — |
| Therapeutic Concepts, PA,Substudy-03 | Houston | Texas | 77004 | — |
| The Crofoot Research Center, Inc.,Substudy-01 | Houston | Texas | 77098 | — |
| MultiCare Rockwood Main Clinic- Research,Substudy-03 | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05585307, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2025 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05585307 live on ClinicalTrials.gov.