Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)
Public ClinicalTrials.gov record NCT05603754. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
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Official title
A Phase 3, Multicenter, Randomized, Double Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint 0.07 mg in Subjects With Moderate to Severe Osteoarthritis Pain of the Knee
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 3 study was a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target (most painful) knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects at a single dose of 0.07 mg lorecivivint per 2 mL injection. This study utilized standard outcomes to evaluate the safety and efficacy of lorecivivint.
Study identification
- NCT ID
- NCT05603754
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 499 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 18, 2022 (Actual)
- Primary completion
- Feb 20, 2024 (Actual)
- Completion
- Feb 20, 2024 (Actual)
- Last update posted
- Sep 1, 2026
2022 – 2024
United States locations
- U.S. sites
- 44
- U.S. states
- 18
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Tucson Orthopaedic Institute | Tucson | Arizona | 85712 | — |
| Core Healthcare Research | Cerritos | California | 90703 | — |
| BioSolutions Clinical Research Center | La Mesa | California | 91942 | — |
| Infinity Clinical Research | Norco | California | 92860 | — |
| Dream Team Clinical Research | Pomona | California | 91767 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Encompass Clinical Research | Spring Valley | California | 97978 | — |
| Millennium Clinical Trials, LLC | Thousand Oaks | California | 91360 | — |
| Unique Clinical Trials | Doral | Florida | 33172 | — |
| Eastern Research, Inc. | Hialeah | Florida | 33013 | — |
| TecTum Research | Hollywood | Florida | 33024 | — |
| Columbus Clinical Services, LLC | Miami | Florida | 33125 | — |
| AppleMed Research Group, LLC | Miami | Florida | 33126 | — |
| Advance Medical Research Center | Miami | Florida | 33135 | — |
| Health and Life Research Institute, LLC | Miami | Florida | 33155 | — |
| BioMed Research and Medical Center | Miami | Florida | 33156 | — |
| Well Pharma Medical Research, Corp | Miami | Florida | 33173 | — |
| South Florida Research Phase I-IV, Inc. | Miami Springs | Florida | 33166 | — |
| Tampa Pain Relief Center | Tampa | Florida | 33603 | — |
| Premier Medical Associates | The Villages | Florida | 32159 | — |
| Conquest Research, LLC | Winter Park | Florida | 32789 | — |
| Pinnacle Trials, Inc. | Stockbridge | Georgia | 30281 | — |
| Chicago Clinical Research Institute | Chicago | Illinois | 60607 | — |
| MediSphere Medical Research Center, LLC | Evansville | Indiana | 47714 | — |
| DelRicht Research - Mandeville | Mandeville | Louisiana | 70471 | — |
| DelRicht Research | New Orleans | Louisiana | 70124 | — |
| DelRicht Research - Prairieville | Prairieville | Louisiana | 70817 | — |
| DelRicht Research - Rockville | Rockville | Maryland | 20852 | — |
| Skylight Health Research | Burlington | Massachusetts | 01803 | — |
| Oakland Medical Research | Troy | Michigan | 48085 | — |
| Healthcare Research Network | Hazelwood | Missouri | 63042 | — |
| Albuquerque Clinical Trials | Albuquerque | New Mexico | 87102 | — |
| Hightop Medical Research Center | Cincinnati | Ohio | 45224 | — |
| Conrad Clinical Research | Edmond | Oklahoma | 73013 | — |
| DelRicht Research - Tulsa | Tulsa | Oklahoma | 74133 | — |
| Clinical Trials of South Carolina | Charleston | South Carolina | 29406 | — |
| Piedmont Research Partners, LLC | Fort Mill | South Carolina | 29707 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| Synergy Groups Medical, LLC | Houston | Texas | 77036 | — |
| Synergy Groups Medical, LLC | Houston | Texas | 77061 | — |
| Clinical Investigations of Texas | Plano | Texas | 75075 | — |
| Diagnostic Research Group | San Antonio | Texas | 78229 | — |
| Wasatch Clinical Research, LLC | Salt Lake City | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05603754, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 1, 2026 · Synced Nov 8, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05603754 live on ClinicalTrials.gov.