Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Public ClinicalTrials.gov record NCT05609578. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Study identification
- NCT ID
- NCT05609578
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Interventions
- Adagrasib oral dose of 400 mg twice daily tablets Drug
- Pembrolizumab Combination Product
- Chemotherapy: Pemetrexed Combination Product
- Cisplatin/Carboplatin Combination Product
Drug · Combination Product
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2022
- Primary completion
- Sep 29, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Jun 22, 2026
2022 – 2026
United States locations
- U.S. sites
- 59
- U.S. states
- 14
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 017-936C | Fountain Valley | California | 92708 | — |
| Local Institution - 017-936 | Fountain Valley | California | 92708 | — |
| Local Institution - 017-851 | Fullerton | California | 92835 | — |
| Local Institution - 017-540 | San Francisco | California | 94158 | — |
| Local Institution - 017-872-I | Aurora | Colorado | 80012 | — |
| Local Institution - 017-872-G | Boulder | Colorado | 80303 | — |
| Local Institution - 017-872-D | Colorado Springs | Colorado | 80907 | — |
| Local Institution - 017-872-J | Colorado Springs | Colorado | 80920 | — |
| Local Institution - 017-872-B | Denver | Colorado | 80218 | — |
| Local Institution - 017-872-F | Denver | Colorado | 80220 | — |
| Local Institution - 017-872-A | Lakewood | Colorado | 80228 | — |
| Local Institution - 017-872-C | Littleton | Colorado | 80218 | — |
| Local Institution - 017-872 | Lone Tree | Colorado | 80124 | — |
| Local Institution - 017-872-E | Pueblo | Colorado | 81003 | — |
| Local Institution - 017-872-H | Thornton | Colorado | 80260 | — |
| Local Institution - 017-829 | Jacksonville | Florida | 32224 | — |
| Local Institution - 017-898 | Lakeland | Florida | 33812 | — |
| Local Institution - 017-972 | Chicago | Illinois | 60637 | — |
| Local Institution - 017-820J | Fairway | Kansas | 66205 | — |
| Local Institution - 017-820A | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820B | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820C | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820H | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820I | Overland Park | Kansas | 66210 | — |
| Local Institution - 017-820 | Westwood | Kansas | 66205 | — |
| Local Institution - 017-388 | Boston | Massachusetts | 02215 | — |
| Local Institution - 017-808 | Boston | Massachusetts | 02215 | — |
| Local Institution - 017-811 | Novi | Michigan | 48377 | — |
| Local Institution - 017-838B | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 017-838C | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 017-830 | Rochester | Minnesota | 55905 | — |
| Local Institution - 017-838 | Saint Louis Park | Minnesota | 55416 | — |
| Local Institution - 017-838A | Saint Louis Park | Minnesota | 55426-5000 | — |
| Local Institution - 017-820F | Kansas City | Missouri | 64116 | — |
| Local Institution - 017-820E | Kansas City | Missouri | 64154 | — |
| Local Institution - 017-820D | Lee's Summit | Missouri | 64064 | — |
| Local Institution - 017-820G | North Kansas City | Missouri | 64116 | — |
| Local Institution - 017-080 | Babylon | New York | 11702 | — |
| Local Institution - 017-088 | Brooklyn | New York | 11210 | — |
| Local Institution - 017-587 | East Syracuse | New York | 13057 | — |
| Local Institution - 017-087 | New Hyde Park | New York | 11042 | — |
| Local Institution - 017-085 | New York | New York | 10028 | — |
| Local Institution - 017-082 | Patchogue | New York | 11772 | — |
| Local Institution - 017-086 | Port Jefferson | New York | 11776 | — |
| Local Institution - 017-081 | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 017-535 | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 017-084 | Riverhead | New York | 11901 | — |
| Local Institution - 017-083 | The Bronx | New York | 10469 | — |
| Local Institution - 017-818 | Cleveland | Ohio | 44195 | — |
| Local Institution - 017-879 | Dallas | Texas | 75246 | — |
| Local Institution - 017-878 | Longview | Texas | 75601 | — |
| Local Institution - 017-878-B | Palestine | Texas | 75801 | — |
| Local Institution - 017-878-C | Paris | Texas | 75460 | — |
| Local Institution - 017-878-A | Tyler | Texas | 75702 | — |
| Local Institution - 017-814-A | Arlington | Virginia | 22205 | — |
| Local Institution - 017-814 | Fairfax | Virginia | 22031 | — |
| Local Institution - 017-814-B | Gainesville | Virginia | 20155 | — |
| Local Institution - 017-814-C | Reston | Virginia | 20190 | — |
| Local Institution - 017-909 | Bellingham | Washington | 98225 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 35 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05609578, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 22, 2026 · Synced Sep 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05609578 live on ClinicalTrials.gov.