ClinicalTrials.gov record
Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
ClinicalTrials.gov ID: NCT05609578
Public ClinicalTrials.gov record NCT05609578. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 12, 2026, 8:03 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Study identification
- NCT ID
- NCT05609578
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Mirati Therapeutics Inc.
- Industry
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Interventions
- Adagrasib oral dose of 400 mg twice daily tablets Drug
- Chemotherapy: Pemetrexed Combination Product
- Cisplatin/Carboplatin Combination Product
- Pembrolizumab Combination Product
Drug · Combination Product
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2022
- Primary completion
- May 31, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Aug 16, 2025
2022 – 2026
United States locations
- U.S. sites
- 84
- U.S. states
- 21
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - Unk025 | Anchorage | Alaska | 99508 | Active, not recruiting |
| Local Institution - 017-591 | Glendale | Arizona | 85304 | Withdrawn |
| Local Institution - 017-821 | Phoenix | Arizona | 85004 | Withdrawn |
| Local Institution - Unk047 | Anaheim | California | 92805 | Active, not recruiting |
| Local Institution - 017-936C | Fountain Valley | California | 92708 | Not yet recruiting |
| MemorialCare - Orange Coast Medical Center | Fountain Valley | California | 92708 | Recruiting |
| Providence Medical Foundation - Virginia K. Crosson Cancer Center - Fullerton | Fullerton | California | 92835 | Recruiting |
| Local Institution - Unk004 | Loma Linda | California | 92354 | Active, not recruiting |
| Local Institution - 017-961 | Los Angeles | California | 90095 | Withdrawn |
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94158 | Recruiting |
| Local Institution - 017-872-I | Aurora | Colorado | 80012 | Not yet recruiting |
| Local Institution - 017-872-G | Boulder | Colorado | 80303 | Not yet recruiting |
| Local Institution - 017-872-D | Colorado Springs | Colorado | 80907 | Not yet recruiting |
| Local Institution - 017-872-J | Colorado Springs | Colorado | 80920 | Not yet recruiting |
| Local Institution - 017-872-B | Denver | Colorado | 80218 | Not yet recruiting |
| Local Institution - 017-872-F | Denver | Colorado | 80220 | Not yet recruiting |
| Local Institution - 017-872-A | Lakewood | Colorado | 80228 | Not yet recruiting |
| Local Institution - 017-872-C | Littleton | Colorado | 80218 | Not yet recruiting |
| USOR - Rocky Mountain Cancer Centers - Lone Tree - Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | Recruiting |
| Local Institution - 017-872-E | Pueblo | Colorado | 81003 | Not yet recruiting |
| Local Institution - 017-872-H | Thornton | Colorado | 80260 | Not yet recruiting |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| The Oncology Institute of Hope and Innovation - Lakeland | Lakeland | Florida | 33812 | Recruiting |
| Local Institution - Unk076 | Miami | Florida | 33136 | Active, not recruiting |
| Local Institution - Unk055 | Orlando | Florida | 32803 | Active, not recruiting |
| Local Institution - Unk062 | Chicago | Illinois | 60612 | Active, not recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Local Institution - 017-820J | Fairway | Kansas | 66205 | Not yet recruiting |
| Local Institution - 017-820A | Kansas City | Kansas | 66160 | Not yet recruiting |
| Local Institution - 017-820B | Kansas City | Kansas | 66160 | Not yet recruiting |
| Local Institution - 017-820C | Kansas City | Kansas | 66160 | Not yet recruiting |
| Local Institution - 017-820H | Kansas City | Kansas | 66160 | Not yet recruiting |
| Local Institution - 017-820I | Overland Park | Kansas | 66210 | Not yet recruiting |
| University of Kansas Cancer Center - Westwood/Richard and Annette Bloch Cancer Care Pavilion | Westwood | Kansas | 66205 | Recruiting |
| Local Institution - 017-965 | Lexington | Kentucky | 40503 | Withdrawn |
| Local Institution - Unk009 | Baltimore | Maryland | 21201 | Active, not recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Local Institution - Unk039 | Burlington | Massachusetts | 01803 | Active, not recruiting |
| Local Institution - Unk069 | Detroit | Michigan | 48201 | Active, not recruiting |
| Local Institution - Unk018 | Lansing | Michigan | 488912 | Active, not recruiting |
| Henry Ford Medical Center - Columbus | Novi | Michigan | 48377 | Recruiting |
| Local Institution - 017-838B | Minneapolis | Minnesota | 55404 | Not yet recruiting |
| Local Institution - 017-838C | Minneapolis | Minnesota | 55404 | Not yet recruiting |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | Recruiting |
| Metro-Minnesota Community Oncology Research Consortium (MMCORC) | Saint Louis Park | Minnesota | 55416 | Recruiting |
| Local Institution - 017-838A | Saint Louis Park | Minnesota | 55426-5000 | Not yet recruiting |
| Local Institution - 017-820F | Kansas City | Missouri | 64116 | Not yet recruiting |
| Local Institution - 017-820E | Kansas City | Missouri | 64154 | Not yet recruiting |
| Local Institution - 017-820D | Lee's Summit | Missouri | 64064 | Not yet recruiting |
| Local Institution - 017-820G | North Kansas City | Missouri | 64116 | Not yet recruiting |
| Local Institution - Unk008 | Osage Beach | Missouri | 65065 | Active, not recruiting |
| Local Institution - Unk058 | Springfield | Missouri | 65807 | Active, not recruiting |
| Local Institution - 017-080 | Babylon | New York | 11702 | Not yet recruiting |
| Local Institution - 017-088 | Brooklyn | New York | 11210 | Not yet recruiting |
| Hematology-Oncology Associates of Central New York - Brittonfield - East Syracuse | East Syracuse | New York | 13057 | Recruiting |
| Local Institution - 017-087 | New Hyde Park | New York | 11042 | Not yet recruiting |
| Local Institution - 017-085 | New York | New York | 10028 | Not yet recruiting |
| Local Institution - 017-082 | Patchogue | New York | 11772 | Not yet recruiting |
| Local Institution - 017-086 | Port Jefferson | New York | 11776 | Not yet recruiting |
| Local Institution - 017-081 | Port Jefferson Station | New York | 11776 | Not yet recruiting |
| New York Cancer & Blood Specialists - Cancer Center - Research Headquarters | Port Jefferson Station | New York | 11776 | Recruiting |
| Local Institution - 017-084 | Riverhead | New York | 11901 | Not yet recruiting |
| Local Institution - 017-945 | The Bronx | New York | 10467 | Withdrawn |
| Local Institution - 017-083 | The Bronx | New York | 10469 | Not yet recruiting |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | Recruiting |
| Local Institution - 017-836 | Kettering | Ohio | 45429 | Withdrawn |
| Local Institution - 017-916 | Memphis | Tennessee | 38104 | Withdrawn |
| Texas Oncology - Dallas Fort Worth (DFW) - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | Recruiting |
| Local Institution - Unk056 | Dallas | Texas | 75390 | Active, not recruiting |
| Local Institution - 017-848 | Houston | Texas | 77030 | Withdrawn |
| Local Institution - 017-999 | Irving | Texas | 75063 | Not yet recruiting |
| USOR - Texas Oncology Northeast Texas - Longview Cancer Center | Longview | Texas | 75601 | Recruiting |
| Local Institution - 017-878-B | Palestine | Texas | 75801 | Not yet recruiting |
| Local Institution - 017-878-C | Paris | Texas | 75460 | Not yet recruiting |
| Local Institution - 017-878-A | Tyler | Texas | 75702 | Not yet recruiting |
| Local Institution - Unk010 | Salt Lake City | Utah | 84106 | Active, not recruiting |
| Local Institution - 017-814-A | Arlington | Virginia | 22205 | Not yet recruiting |
| Local Institution - Unk066 | Fairfax | Virginia | 22031 | Active, not recruiting |
| Virginia Cancer Specialists - Fairfax Office | Fairfax | Virginia | 22031 | Recruiting |
| Local Institution - 017-814-B | Gainesville | Virginia | 20155 | Not yet recruiting |
| Local Institution - 017-814-C | Reston | Virginia | 20190 | Not yet recruiting |
| PeaceHealth St. Joseph Medical Center | Bellingham | Washington | 98225 | Recruiting |
| Local Institution - Unk036 | Huntington | West Virginia | 25705 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 82 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05609578, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2025 · Synced May 12, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05609578 live on ClinicalTrials.gov.