Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation
Public ClinicalTrials.gov record NCT05609578. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Trial of Combination Therapies With Adagrasib in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line setting for patients with advanced NSCLC with TPS ≥ 1%, TPS \<50% and KRAS G12C mutation
Study identification
- NCT ID
- NCT05609578
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Interventions
- Adagrasib oral dose of 400 mg twice daily tablets Drug
- Pembrolizumab Combination Product
- Chemotherapy: Pemetrexed Combination Product
- Cisplatin/Carboplatin Combination Product
Drug · Combination Product
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 22, 2022 (Actual)
- Primary completion
- Sep 30, 2026 (Estimated)
- Completion
- Dec 1, 2026 (Estimated)
- Last update posted
- Jun 23, 2026
2022 – 2026
United States locations
- U.S. sites
- 59
- U.S. states
- 14
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 017-936C | Fountain Valley | California | 92708 | — |
| Local Institution - 017-936 | Fountain Valley | California | 92708 | — |
| Local Institution - 017-851 | Fullerton | California | 92835 | — |
| Local Institution - 017-540 | San Francisco | California | 94158 | — |
| Local Institution - 017-872-I | Aurora | Colorado | 80012 | — |
| Local Institution - 017-872-G | Boulder | Colorado | 80303 | — |
| Local Institution - 017-872-D | Colorado Springs | Colorado | 80907 | — |
| Local Institution - 017-872-J | Colorado Springs | Colorado | 80920 | — |
| Local Institution - 017-872-B | Denver | Colorado | 80218 | — |
| Local Institution - 017-872-F | Denver | Colorado | 80220 | — |
| Local Institution - 017-872-A | Lakewood | Colorado | 80228 | — |
| Local Institution - 017-872-C | Littleton | Colorado | 80218 | — |
| Local Institution - 017-872 | Lone Tree | Colorado | 80124 | — |
| Local Institution - 017-872-E | Pueblo | Colorado | 81003 | — |
| Local Institution - 017-872-H | Thornton | Colorado | 80260 | — |
| Local Institution - 017-829 | Jacksonville | Florida | 32224 | — |
| Local Institution - 017-898 | Lakeland | Florida | 33812 | — |
| Local Institution - 017-972 | Chicago | Illinois | 60637 | — |
| Local Institution - 017-820J | Fairway | Kansas | 66205 | — |
| Local Institution - 017-820A | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820B | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820C | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820H | Kansas City | Kansas | 66160 | — |
| Local Institution - 017-820I | Overland Park | Kansas | 66210 | — |
| Local Institution - 017-820 | Westwood | Kansas | 66205 | — |
| Local Institution - 017-388 | Boston | Massachusetts | 02215 | — |
| Local Institution - 017-808 | Boston | Massachusetts | 02215 | — |
| Local Institution - 017-811 | Novi | Michigan | 48377 | — |
| Local Institution - 017-838B | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 017-838C | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 017-830 | Rochester | Minnesota | 55905 | — |
| Local Institution - 017-838 | Saint Louis Park | Minnesota | 55416 | — |
| Local Institution - 017-838A | Saint Louis Park | Minnesota | 55426-5000 | — |
| Local Institution - 017-820F | Kansas City | Missouri | 64116 | — |
| Local Institution - 017-820E | Kansas City | Missouri | 64154 | — |
| Local Institution - 017-820D | Lee's Summit | Missouri | 64064 | — |
| Local Institution - 017-820G | North Kansas City | Missouri | 64116 | — |
| Local Institution - 017-080 | Babylon | New York | 11702 | — |
| Local Institution - 017-088 | Brooklyn | New York | 11210 | — |
| Local Institution - 017-587 | East Syracuse | New York | 13057 | — |
| Local Institution - 017-087 | New Hyde Park | New York | 11042 | — |
| Local Institution - 017-085 | New York | New York | 10028 | — |
| Local Institution - 017-082 | Patchogue | New York | 11772 | — |
| Local Institution - 017-086 | Port Jefferson | New York | 11776 | — |
| Local Institution - 017-081 | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 017-535 | Port Jefferson Station | New York | 11776 | — |
| Local Institution - 017-084 | Riverhead | New York | 11901 | — |
| Local Institution - 017-083 | The Bronx | New York | 10469 | — |
| Local Institution - 017-818 | Cleveland | Ohio | 44195 | — |
| Local Institution - 017-879 | Dallas | Texas | 75246 | — |
| Local Institution - 017-878 | Longview | Texas | 75601 | — |
| Local Institution - 017-878-B | Palestine | Texas | 75801 | — |
| Local Institution - 017-878-C | Paris | Texas | 75460 | — |
| Local Institution - 017-878-A | Tyler | Texas | 75702 | — |
| Local Institution - 017-814-A | Arlington | Virginia | 22205 | — |
| Local Institution - 017-814 | Fairfax | Virginia | 22031 | — |
| Local Institution - 017-814-B | Gainesville | Virginia | 20155 | — |
| Local Institution - 017-814-C | Reston | Virginia | 20190 | — |
| Local Institution - 017-909 | Bellingham | Washington | 98225 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 35 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05609578, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 23, 2026 · Synced Nov 4, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05609578 live on ClinicalTrials.gov.