Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adult Participants 18 Years of Age and Older
Public ClinicalTrials.gov record NCT05624606. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Safety and Immunogenicity of Quadrivalent Influenza mRNA Vaccine MRT5410 in Adults Aged 18 Years and Older
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and immunogenicity of a single intramuscular (IM) injection of up to 3 dose levels of Quadrivalent Influenza mRNA Vaccine MRT5410 compared to an active control (QIV SD, QIV HD \[adults ≥ 65 years of age only\], or RIV4) in adults 18 years of age and older.
Study identification
- NCT ID
- NCT05624606
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 682 participants
Conditions and interventions
Conditions
Interventions
- Quadrivalent Influenza mRNA Vaccine MRT5410 Biological
- Quadrivalent Recombinant Influenza vaccine RIV4 Biological
- Quadrivalent Inactivated Influenza Standard Dose QIV-SD Biological
- Quadrivalent Inactivated Influenza High Dose QIV-HD Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 27, 2022
- Primary completion
- Mar 27, 2024
- Completion
- Mar 27, 2024
- Last update posted
- Mar 17, 2025
2022 – 2024
United States locations
- U.S. sites
- 23
- U.S. states
- 10
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Joint Clinical Trials Huntington Park Site Number : 8400032 | Huntington Park | California | 90255 | — |
| Long Beach Clinical Trials Site Number : 8400056 | Long Beach | California | 90806 | — |
| Velocity Clinical Research, North Hollywood Site Number : 8400063 | North Hollywood | California | 91606 | — |
| California Research Foundation Site Number : 8400001 | San Diego | California | 92123-1881 | — |
| SIMEDHealth, LLC Site Number : 8400042 | Gainesville | Florida | 32607 | — |
| Indago Research and Health Center Site Number : 8400002 | Hialeah | Florida | 33012 | — |
| Research Centers of America Site Number : 8400011 | Hollywood | Florida | 33024 | — |
| Florida International Research Center Site Number : 8400009 | Miami | Florida | 33173 | — |
| Palm Beach Research Center Site Number : 8400041 | West Palm Beach | Florida | 33409 | — |
| Velocity Clinical Research Site Number : 8400024 | Meridian | Idaho | 83642 | — |
| Brengle Family Medicine Site Number : 8400040 | Indianapolis | Indiana | 46260 | — |
| AMR Lexington Site Number : 8400035 | Lexington | Kentucky | 40509 | — |
| Meridian Clinical Research Site Number : 8400017 | Norfolk | Nebraska | 68701 | — |
| Velocity Clinical Research Site Number : 8400034 | Omaha | Nebraska | 68134 | — |
| WR-CRCN, LLC Site Number : 8400060 | Las Vegas | Nevada | 89106 | — |
| Coastal Carolina Research Center - N Charleston Site Number : 8400007 | North Charleston | South Carolina | 29405 | — |
| AMR Knoxville Site Number : 8400021 | Knoxville | Tennessee | 37919 | — |
| Elligo Health Research, Inc. Site Number : 8400037 | Austin | Texas | 78704 | — |
| Tekton Research, Inc Site Number : 8400051 | Austin | Texas | 78745 | — |
| DM Clinical Research Site Number : 8400046 | Humble | Texas | 77338 | — |
| Clinical Trials of Texas, Inc. - PPDS Site Number : 8400043 | San Antonio | Texas | 78229 | — |
| DM Clinical Research - Sugar Land Site Number : 8400045 | Sugar Land | Texas | 77478 | — |
| Martin Diagnostic Clinic Site Number : 8400058 | Tomball | Texas | 77375 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05624606, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2025 · Synced Sep 1, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05624606 live on ClinicalTrials.gov.