ClinicalTrials.gov record
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
ClinicalTrials.gov ID: NCT05636176
Public ClinicalTrials.gov record NCT05636176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will be done to see if ziltivekimab can be used to treat people living with heart failure and inflammation. Participants will either get ziltivekimab or placebo. Participants will get study medicine for once-monthly injections either in a pre-filled syringe to inject the study medicine into a skinfold or a pen-injector to inject the study medicine into flat skin. The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have to use a study app on their phone to record and share information about all their injections of study medicine and to fill in questionnaires.
Study identification
- NCT ID
- NCT05636176
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 4,899 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 7, 2023
- Primary completion
- Jul 1, 2027
- Completion
- Jul 1, 2027
- Last update posted
- Aug 11, 2026
2023 – 2027
United States locations
- U.S. sites
- 172
- U.S. states
- 40
- U.S. cities
- 144
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC | Alexander City | Alabama | 35010 | — |
| Eastern Shore Rsrch Inst, LLC | Fairhope | Alabama | 36532 | — |
| Heart Center Rsrch_Hunstville | Huntsville | Alabama | 35801 | — |
| Banner University Medical Ctr | Phoenix | Arizona | 85006 | — |
| Cardiology & Medicine Clinic | Little Rock | Arkansas | 72204 | — |
| InvivoCure -2 | Alhambra | California | 91801 | — |
| National Heart Institute Cal | Beverly Hills | California | 90211 | — |
| Valley Clinical Trials | Covina | California | 91723 | — |
| Scripps Memorial Hospital La Jolla | La Jolla | California | 90237 | — |
| Purushotham & Akther Kotha MD, inc. | La Mesa | California | 91942 | — |
| VA Loma Linda Hlthcr Sys | Loma Linda | California | 92357 | — |
| Biopharma Clinical Research Services, LLC | Los Angeles | California | 90035 | — |
| VA Greater Los Angeles Hlthcare System | Los Angeles | California | 90073 | — |
| VAGrtrLosAngelesHlthcareSystem | Los Angeles | California | 90073 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| UCI Health | Orange | California | 92868 | — |
| Stanford Univ School of Med | Palo Alto | California | 94304 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| North America Research Institute | San Dimas | California | 91773 | — |
| Manshadi Heart Institute | Stockton | California | 95204 | — |
| Lundquist Inst-Biomed Innovtn | Torrance | California | 90502 | — |
| InvivoCure | Van Nuys | California | 91405 | — |
| Rocky Mountain Regional VAMC | Aurora | Colorado | 80045 | — |
| InvivoCure -2 | Denver | Colorado | 80012 | — |
| S Denver Cardiology Associates | Littleton | Colorado | 80120 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Cardiology Associates of Fairfield County | Stamford | Connecticut | 06905 | — |
| Pioneer Clinical Studies-Coral Gables | Coral Gables | Florida | 33134 | — |
| Nature Coast Clin Rsrch_Crystal River | Crystal River | Florida | 34429 | — |
| Integrative Research Assoc Inc | Fort Lauderdale | Florida | 33312 | — |
| New Generation of Medical Research | Hialeah | Florida | 33016 | — |
| Memorial Region Hosp_Hollywood | Hollywood | Florida | 33021 | — |
| E Coast Inst for Rsrch LLC_Jacksonville | Jacksonville | Florida | 32204 | — |
| Jacksonville Ctr for Clin Res | Jacksonville | Florida | 32216 | — |
| Baptist Health Research Institute | Jacksonville | Florida | 32258 | — |
| Baptist Health South Florida | Miami | Florida | 33173 | — |
| Pioneer Clinical Studies-Coral Gables | Miami | Florida | 33176 | — |
| NCH Research Institute | Naples | Florida | 34102 | — |
| Amavita Research Services, LLC | North Miami Beach | Florida | 33169 | — |
| Ocala Cardiovascular Research | Ocala | Florida | 34471 | — |
| Ormond Beach Clinical Research | Ormond Beach | Florida | 32174 | — |
| St Johns Ctr Clin Rsch-St. Aug | Saint Augustine | Florida | 32086 | — |
| Cardio Partners Clin Res Inst | Wellington | Florida | 33449 | — |
| Winter Haven Hospital | Winter Haven | Florida | 33881 | — |
| Guardian Research Org LLC | Winter Park | Florida | 32792 | — |
| Morehouse School of Medicine | Atlanta | Georgia | 30310 | — |
| Emory University School of Medicine_Atlanta | Atlanta | Georgia | 30322 | — |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | — |
| GA Arrhythmia Cons & Rsch Inst | Macon | Georgia | 31201 | — |
| The Queen's Medical Center | Honolulu | Hawaii | 96817 | — |
| St. Luke's Idaho Cardiology Associates | Meridian | Idaho | 83642 | — |
| Endeavor Health Clinical Operations-NCH | Arlington Heights | Illinois | 60005 | — |
| Advocate Good Samaritan | Downers Grove | Illinois | 60515 | — |
| Chicago Medical Research LLC | Hazel Crest | Illinois | 60429 | — |
| Midwest Cardiovascular Institute | Naperville | Illinois | 60540 | — |
| OSF HealthCare_Cardiovasc Inst | Peoria | Illinois | 61614 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| Midwest Cardiovascu Rsrch Foundation | Elkhart | Indiana | 46514 | — |
| Asha Clinical Rsch-Munster, LLC | Hammond | Indiana | 46324 | — |
| Franciscan Network-IN Heart PHY | Indianapolis | Indiana | 46237 | — |
| Witham Health Services | Lebanon | Indiana | 46052 | — |
| Cardiovascular Rsrch of NW_IN | Munster | Indiana | 46321 | — |
| Reid Physician Associates | Richmond | Indiana | 47374 | — |
| University Of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Midwest Heart & Vasc Spec | Overland Park | Kansas | 66211 | — |
| Baptist Health Hardin | Elizabethtown | Kentucky | 42701 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| University Of Louisville | Louisville | Kentucky | 40202 | — |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | — |
| Baptist Health Louisville | Louisville | Kentucky | 40207 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| LOUISIANA HEART Center | Bogalusa | Louisiana | 70427 | — |
| Heart Clinic of Hammond | Hammond | Louisiana | 70403 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Ascension Saint Agnes Heart Ca | Baltimore | Maryland | 21229 | — |
| Johns Hopkins University_Baltimore | Baltimore | Maryland | 21287 | — |
| Capitol Cardiology Assoc_Lanham | Lanham | Maryland | 20706 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Mass General Community Physicians | Haverhill | Massachusetts | 01830 | — |
| University of Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Detroit Med Center-Wayne State | Detroit | Michigan | 48201 | — |
| Henry Ford Hlth System_Detroit | Detroit | Michigan | 48202 | — |
| Elite Research Center | Flint | Michigan | 48532 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Trinity Health Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| Fairview Health Services | Maplewood | Minnesota | 55109 | — |
| Minneapolis VA Health Care Sys | Minneapolis | Minnesota | 55417 | — |
| Hawthorne Health | Diamondhead | Mississippi | 39525 | — |
| Cardiolg Assoc Rsch LLC_Tupelo | Tupelo | Mississippi | 38801 | — |
| St Louis Heart & Vascular, P.C. | St Louis | Missouri | 63136 | — |
| Logan Health Research | Kalispell | Montana | 59901 | — |
| Univ. of Nebraska Medical Center_Omaha | Omaha | Nebraska | 68198 | — |
| Palm Research Center Inc. | Las Vegas | Nevada | 89128 | — |
| Advanced Heart Care LLC | Bridgewater | New Jersey | 08807-3064 | — |
| Heart House_Elmer | Elmer | New Jersey | 08318 | — |
| NJ Heart | Linden | New Jersey | 07036 | — |
| Barnabas Health | Livingston | New Jersey | 07039 | — |
| Inspira Health - Cardiology | Mullica Hill | New Jersey | 08062 | — |
| Saint Michael's Med Ctr NJ | Newark | New Jersey | 07102 | — |
| The Valley Hosptial - Ridgewood | Ridgewood | New Jersey | 07450 | — |
| The Valley Hosptial | Ridgewood | New Jersey | 07450 | — |
| Capital Cardiology Associates_Albany | Albany | New York | 12211 | — |
| University at Buffalo_Erie County Med Ctr | Buffalo | New York | 14215 | — |
| Marian David, MD, PC | Kew Gardens | New York | 11415 | — |
| Mount Sinai Hosp at NYC | New York | New York | 10019 | — |
| NY Presbyt Hosp-W Cornell Med | New York | New York | 10021 | — |
| Mount Sinai Hosp at NYC | New York | New York | 10029 | — |
| Harlem Cardiology_Madison ave | New York | New York | 10035 | — |
| Laurelton Heart Specialist PC | Rosedale | New York | 11422 | — |
| Saratoga Clinical Research | Saratoga Springs | New York | 12866 | — |
| Stony Brook University Hospital | Stony Brook | New York | 11794 | — |
| Chear Center LLC | The Bronx | New York | 10455 | — |
| UNC Cardiology Outpatient Ctr | Chapel Hill | North Carolina | 27599 | — |
| Hawthorne Health NC | Concord | North Carolina | 28025 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| Medication Mgmnt, LLC_Grnsboro | Greensboro | North Carolina | 27405 | — |
| Duke University/Southeastern | Lumberton | North Carolina | 28358 | — |
| Carteret Medical Group | Morehead City | North Carolina | 28557 | — |
| UNC Rex Healthcare | Raleigh | North Carolina | 27607 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| K&R Research Llc | Marion | Ohio | 43302 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | 73135 | — |
| Capital Area Research LLC | Camp Hill | Pennsylvania | 17011 | — |
| Penn State Hlth Holy Spirit Med Ctr | Camp Hill | Pennsylvania | 17011 | — |
| Geisinger Medical Center | Danville | Pennsylvania | 17822 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Heart Grp_ Lancaster Gen Hlth | Lancaster | Pennsylvania | 17603 | — |
| Thomas Jefferson University_Philadelphia | Philadelphia | Pennsylvania | 19114 | — |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15212 | — |
| Penn State Health-Berks Cardiology | Wyomissing | Pennsylvania | 19610 | — |
| Prisma Health-Midlands | Columbia | South Carolina | 29203 | — |
| Monument Health Clinical Rsrch | Rapid City | South Dakota | 57701 | — |
| Sanford Health_Sioux Falls | Sioux Falls | South Dakota | 57117 | — |
| Apex Research Foundation, LLC | Jackson | Tennessee | 38301 | — |
| The Jackson Clinic, PA | Jackson | Tennessee | 38305 | — |
| Tennova HC Turkey Creek MC | Knoxville | Tennessee | 37934 | — |
| Heart MD_Allen TX | Allen | Texas | 75013 | — |
| PharmaTex Research, LLC | Amarillo | Texas | 79106 | — |
| Austin Heart | Austin | Texas | 78756 | — |
| UTD SW Medical Center-Dallas | Dallas | Texas | 75390 | — |
| Dallas Heart and Vascular | Duncanville | Texas | 75137 | — |
| David Turbay, MD, PLLC | El Paso | Texas | 79905 | — |
| Biopharma Informatic_Houston | Houston | Texas | 77025 | — |
| Houston Methodist Hospital | Houston | Texas | 77030-2703 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Texas Heart Inst Medical Ctr | Houston | Texas | 77030 | — |
| UT Physicians - Houston Medical Center | Houston | Texas | 77030 | — |
| Card Specialists of Willowbrook | Houston | Texas | 77070 | — |
| Texas Institute of Cardiology PA | McKinney | Texas | 75071 | — |
| Clinical Advancement Center | San Antonio | Texas | 78212 | — |
| Audie L. Murphy VA Hospital | San Antonio | Texas | 78229 | — |
| Sherman Clinical Research | Sherman | Texas | 75092 | — |
| University of Vermont Med Ctr | Burlington | Vermont | 05401 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| James River Cardiology | Chesterfield | Virginia | 23832 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
| Sentara Health Research Center | Norfolk | Virginia | 23507 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| VA Medical Center_Salem | Salem | Virginia | 24153-6404 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Valley Health Link | Winchester | Virginia | 22601 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Swedish Medical Center_Seattle | Seattle | Washington | 98122-5789 | — |
| Providence Med Research Ctr | Spokane | Washington | 99204 | — |
| WVU Heart & Vascular Institute | Morgantown | West Virginia | 26506 | — |
| William S Middleton Mem VA Hosp | Madison | Wisconsin | 53705 | — |
| Aurora St. Luke's Medi Ctr | Milwaukee | Wisconsin | 53215 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 841 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05636176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05636176 live on ClinicalTrials.gov.