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Recruiting Phase 3 Interventional

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

ClinicalTrials.gov ID: NCT05636176

Public ClinicalTrials.gov record NCT05636176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 20, 2026, 7:29 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Effects of Ziltivekimab Versus Placebo on Morbidity and Mortality in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction and Systemic Inflammation

Study identification

NCT ID
NCT05636176
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novo Nordisk A/S
Industry
Enrollment
5,600 participants

Conditions and interventions

Conditions

Interventions

  • Placebo Drug
  • Ziltivekimab Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
May 7, 2023
Primary completion
Jul 1, 2027
Completion
Jul 1, 2027
Last update posted
Mar 10, 2026

2023 – 2027

United States locations

U.S. sites
171
U.S. states
40
U.S. cities
144
Facility City State ZIP Site status
Advanced Cardiovascular, LLC Alexander City Alabama 35010 Recruiting
Eastern Shore Rsrch Inst, LLC Fairhope Alabama 36532 Recruiting
Heart Center Rsrch_Hunstville Huntsville Alabama 35801 Recruiting
Banner University Medical Ctr Phoenix Arizona 85006 Not yet recruiting
Cardiology & Medicine Clinic Little Rock Arkansas 72204 Completed
InvivoCure -2 Alhambra California 91801 Recruiting
National Heart Institute Cal Beverly Hills California 90211 Recruiting
Valley Clinical Trials Covina California 91723 Recruiting
Scripps Memorial Hospital La Jolla La Jolla California 90237 Completed
Purushotham & Akther Kotha MD, inc. La Mesa California 91942 Recruiting
VA Loma Linda Hlthcr Sys Loma Linda California 92357 Recruiting
Biopharma Clinical Research Services, LLC Los Angeles California 90035 Recruiting
VA Greater Los Angeles Hlthcare System Los Angeles California 90073 Recruiting
VAGrtrLosAngelesHlthcareSystem Los Angeles California 90073 Recruiting
Valley Clinical Trials, Inc. Northridge California 91325 Recruiting
UCI Health Orange California 92868 Completed
Stanford Univ School of Med Palo Alto California 94304 Completed
San Diego Cardiac Center San Diego California 92123 Recruiting
North America Research Institute San Dimas California 91773 Recruiting
Manshadi Heart Institute Stockton California 95204 Recruiting
Lundquist Inst-Biomed Innovtn Torrance California 90502 Recruiting
InvivoCure Van Nuys California 91405 Recruiting
Rocky Mountain Regional VAMC Aurora Colorado 80045 Recruiting
InvivoCure -2 Denver Colorado 80012 Completed
S Denver Cardiology Associates Littleton Colorado 80120 Completed
Bridgeport Hospital Bridgeport Connecticut 06610 Recruiting
Cardiology Associates of Fairfield County Stamford Connecticut 06905 Recruiting
Pioneer Clinical Studies-Coral Gables Coral Gables Florida 33134 Recruiting
Nature Coast Clin Rsrch_Crystal River Crystal River Florida 34429 Recruiting
Integrative Research Assoc Inc Fort Lauderdale Florida 33312 Completed
New Generation of Medical Research Hialeah Florida 33016 Not yet recruiting
Memorial Region Hosp_Hollywood Hollywood Florida 33021 Recruiting
E Coast Inst for Rsrch LLC_Jacksonville Jacksonville Florida 32204 Completed
Jacksonville Ctr for Clin Res Jacksonville Florida 32216 Recruiting
Baptist Health Research Institute Jacksonville Florida 32258 Recruiting
Baptist Health South Florida Miami Florida 33173 Recruiting
Pioneer Clinical Studies-Coral Gables Miami Florida 33176 Recruiting
NCH Research Institute Naples Florida 34102 Recruiting
Amavita Research Services, LLC North Miami Beach Florida 33169 Recruiting
Ocala Cardiovascular Research Ocala Florida 34471 Recruiting
Ormond Beach Clinical Research Ormond Beach Florida 32174 Recruiting
St Johns Ctr Clin Rsch-St. Aug Saint Augustine Florida 32086 Recruiting
Cardio Partners Clin Res Inst Wellington Florida 33449 Recruiting
Winter Haven Hospital Winter Haven Florida 33881 Recruiting
Guardian Research Org LLC Winter Park Florida 32792 Recruiting
Morehouse School of Medicine Atlanta Georgia 30310 Recruiting
Emory University School of Medicine_Atlanta Atlanta Georgia 30322 Recruiting
NSC Research, Inc Johns Creek Georgia 30024 Recruiting
GA Arrhythmia Cons & Rsch Inst Macon Georgia 31201 Recruiting
The Queen's Medical Center Honolulu Hawaii 96817 Completed
St. Luke's Idaho Cardiology Associates Meridian Idaho 83642 Recruiting
Endeavor Health Clinical Operations-NCH Arlington Heights Illinois 60005 Completed
Advocate Good Samaritan Downers Grove Illinois 60515 Completed
Chicago Medical Research LLC Hazel Crest Illinois 60429 Recruiting
Midwest Cardiovascular Institute Naperville Illinois 60540 Recruiting
OSF HealthCare_Cardiovasc Inst Peoria Illinois 61614 Recruiting
Methodist Medical Center of Illinois Peoria Illinois 61636 Recruiting
Midwest Cardiovascu Rsrch Foundation Elkhart Indiana 46514 Recruiting
Asha Clinical Rsch-Munster, LLC Hammond Indiana 46324 Recruiting
Franciscan Network-IN Heart PHY Indianapolis Indiana 46237 Recruiting
Witham Health Services Lebanon Indiana 46052 Completed
Cardiovascular Rsrch of NW_IN Munster Indiana 46321 Recruiting
Reid Physician Associates Richmond Indiana 47374 Recruiting
University Of Iowa Hospitals and Clinics Iowa City Iowa 52242 Recruiting
Midwest Heart & Vasc Spec Overland Park Kansas 66211 Not yet recruiting
Baptist Health Hardin Elizabethtown Kentucky 42701 Recruiting
The Research Group of Lexington LLC Lexington Kentucky 40503 Completed
University Of Louisville Louisville Kentucky 40202 Completed
Robley Rex VA Medical Center Louisville Kentucky 40206 Completed
Baptist Health Louisville Louisville Kentucky 40207 Recruiting
Cambridge Medical Trials Alexandria Louisiana 71301 Completed
LOUISIANA HEART Center Bogalusa Louisiana 70427 Recruiting
Heart Clinic of Hammond Hammond Louisiana 70403 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Ascension Saint Agnes Heart Ca Baltimore Maryland 21229 Recruiting
Johns Hopkins University_Baltimore Baltimore Maryland 21287 Recruiting
Capitol Cardiology Assoc_Lanham Lanham Maryland 20706 Recruiting
MD Medical Research Oxon Hill Maryland 20745 Recruiting
Pentucket Medical Associates Haverhill Massachusetts 01830 Recruiting
University of Michigan Medicine Ann Arbor Michigan 48109 Completed
Detroit Med Center-Wayne State Detroit Michigan 48201 Recruiting
Henry Ford Hlth System_Detroit Detroit Michigan 48202 Completed
Elite Research Center Flint Michigan 48532 Completed
Healthy Heart Cardiology Grand Rapids Michigan 49546 Completed
Trinity Health Michigan Heart Ypsilanti Michigan 48197 Recruiting
Fairview Health Services Maplewood Minnesota 55109 Recruiting
Minneapolis VA Health Care Sys Minneapolis Minnesota 55417 Recruiting
Hawthorne Health Diamondhead Mississippi 39525 Not yet recruiting
Cardiolg Assoc Rsch LLC_Tupelo Tupelo Mississippi 38801 Completed
St Louis Heart & Vascular, P.C. St Louis Missouri 63136 Recruiting
Logan Health Research Kalispell Montana 59901 Completed
Univ. of Nebraska Medical Center_Omaha Omaha Nebraska 68198 Recruiting
Palm Research Center Inc. Las Vegas Nevada 89128 Recruiting
Advanced Heart Care LLC Bridgewater New Jersey 08807-3064 Completed
Heart House_Elmer Elmer New Jersey 08318 Completed
NJ Heart Linden New Jersey 07036 Recruiting
Barnabas Health Livingston New Jersey 07039 Recruiting
Inspira Health Mullica Hill New Jersey 08062 Recruiting
Saint Michael's Med Ctr NJ Newark New Jersey 07102 Not yet recruiting
The Valley Hosptial Ridgewood New Jersey 07450 Not yet recruiting
Capital Cardiology Associates_Albany Albany New York 12211 Recruiting
University at Buffalo_Erie County Med Ctr Buffalo New York 14215 Completed
Marian David, MD, PC Kew Gardens New York 11415 Completed
Mount Sinai Hosp at NYC New York New York 10019 Recruiting
NY Presbyt Hosp-W Cornell Med New York New York 10021 Recruiting
Mount Sinai Hosp at NYC New York New York 10029 Recruiting
Harlem Cardiology_Madison ave New York New York 10035 Completed
Laurelton Heart Specialist PC Rosedale New York 11422 Recruiting
Saratoga Clinical Research Saratoga Springs New York 12866 Recruiting
Stony Brook University Hospital Stony Brook New York 11794 Recruiting
Chear Center LLC The Bronx New York 10455 Recruiting
UNC Cardiology Outpatient Ctr Chapel Hill North Carolina 27599 Completed
Hawthorne Health NC Concord North Carolina 28025 Not yet recruiting
Duke University Durham North Carolina 27710 Recruiting
Medication Mgmnt, LLC_Grnsboro Greensboro North Carolina 27405 Recruiting
Duke University/Southeastern Lumberton North Carolina 28358 Not yet recruiting
Carteret Medical Group Morehead City North Carolina 28557 Recruiting
UNC Rex Healthcare Raleigh North Carolina 27607 Recruiting
Aultman Hospital Canton Ohio 44710 Recruiting
K&R Research Llc Marion Ohio 43302 Recruiting
Rama Research LLC Marion Ohio 43302 Recruiting
South Oklahoma Heart Research, LLC Oklahoma City Oklahoma 73135 Recruiting
Capital Area Research LLC Camp Hill Pennsylvania 17011 Recruiting
Penn State Hlth Holy Spirit Med Ctr Camp Hill Pennsylvania 17011 Recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Penn State Hershey Medical Center Hershey Pennsylvania 17033 Completed
Heart Grp_ Lancaster Gen Hlth Lancaster Pennsylvania 17603 Completed
Thomas Jefferson University_Philadelphia Philadelphia Pennsylvania 19114 Recruiting
Allegheny Health Network Pittsburgh Pennsylvania 15212 Completed
Penn State Health-Berks Cardiology Wyomissing Pennsylvania 19610 Recruiting
Prisma Health-Midlands Columbia South Carolina 29203 Completed
Monument Health Clinical Rsrch Rapid City South Dakota 57701 Recruiting
Sanford Health_Sioux Falls Sioux Falls South Dakota 57117 Recruiting
Apex Research Foundation, LLC Jackson Tennessee 38301 Recruiting
The Jackson Clinic, PA Jackson Tennessee 38305 Recruiting
Tennova HC Turkey Creek MC Knoxville Tennessee 37934 Recruiting
Heart MD_Allen TX Allen Texas 75013 Recruiting
PharmaTex Research, LLC Amarillo Texas 79106 Recruiting
Austin Heart Austin Texas 78756 Recruiting
UTD SW Medical Center-Dallas Dallas Texas 75390 Recruiting
Dallas Heart and Vascular Duncanville Texas 75137 Recruiting
David Turbay, MD, PLLC El Paso Texas 79905 Recruiting
Biopharma Informatic_Houston Houston Texas 77025 Recruiting
Houston Methodist Hospital Houston Texas 77030-2703 Recruiting
Houston Methodist Hospital Houston Texas 77030 Not yet recruiting
Texas Heart Inst Medical Ctr Houston Texas 77030 Completed
UT Physicians - Houston Medical Center Houston Texas 77030 Completed
Card Specialists of Willowbrook Houston Texas 77070 Recruiting
Texas Institute of Cardiology PA McKinney Texas 75071 Recruiting
Clinical Advancement Center San Antonio Texas 78212 Recruiting
Audie L. Murphy VA Hospital San Antonio Texas 78229 Completed
Sherman Clinical Research Sherman Texas 75092 Recruiting
University of Vermont Med Ctr Burlington Vermont 05401 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Virginia Charlottesville Virginia 22908 Recruiting
James River Cardiology Chesterfield Virginia 23832 Recruiting
Virginia Heart Falls Church Virginia 22042 Completed
Carient Heart and Vascular Manassas Virginia 20109 Recruiting
York Clinical Research LLC Norfolk Virginia 23504 Recruiting
Sentara Health Research Center Norfolk Virginia 23507 Recruiting
Virginia Commonwealth University Richmond Virginia 23298 Completed
Roanoke Heart Institute Roanoke Virginia 24014 Completed
VA Medical Center_Salem Salem Virginia 24153-6404 Recruiting
Selma Medical Associates Winchester Virginia 22601-3834 Recruiting
Valley Health Link Winchester Virginia 22601 Recruiting
Virginia Mason Medical Center Seattle Washington 98101 Completed
Swedish Medical Center_Seattle Seattle Washington 98122-5789 Not yet recruiting
Providence Med Research Ctr Spokane Washington 99204 Recruiting
WVU Heart & Vascular Institute Morgantown West Virginia 26506 Completed
William S Middleton Mem VA Hosp Madison Wisconsin 53705 Recruiting
Aurora St. Luke's Medi Ctr Milwaukee Wisconsin 53215 Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 840 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05636176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 10, 2026 · Synced Apr 20, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05636176 live on ClinicalTrials.gov.

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