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Recruiting Phase 2 Interventional

Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

ClinicalTrials.gov ID: NCT05640999

Public ClinicalTrials.gov record NCT05640999. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 2:51 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase II Study of Tailored Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endormetrial Cancer (RAINBO BLUE & TAPER)

Study identification

NCT ID
NCT05640999
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Canadian Cancer Trials Group
Network
Enrollment
393 participants

Conditions and interventions

Interventions

  • Adjuvant radiotherapy (EBRT +/- brachytherapy) Radiation
  • Observation Other
  • Vaginal brachytherapy Radiation

Radiation · Other

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 18, 2022
Primary completion
Dec 30, 2028
Completion
Jun 29, 2029
Last update posted
May 3, 2026

2022 – 2029

United States locations

U.S. sites
64
U.S. states
28
U.S. cities
51
Facility City State ZIP Site status
Alaska Womens Cancer Care Anchorage Alaska 99508 Recruiting
University of Arizona Cancer Center Tucson Arizona 85719 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
Huntington Memorial Hospital Pasadena California 91105 Recruiting
Sutter Medical Center Sacramento Sacramento California 95816 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
AdventHealth Porter Denver Colorado 80210 Recruiting
University of Miami School of Medicine Miami Florida 33136 Recruiting
Sarasota Memorial Hospital - Venice N. Venice Florida 34275 Recruiting
Florida Cancer Specialists - Sarasota Downtown Sarasota Florida 34236 Recruiting
First Physicians Group-Sarasota Sarasota Florida 34239 Recruiting
Sarasota Memorial Hospital Sarasota Florida 34239 Recruiting
Sarasota Memorial Health Care Centre Sarasota Florida 34243 Recruiting
Florida Cancer Specialists - Venice Pinebrook Venice Florida 34275 Recruiting
Grady Health System Atlanta Georgia 30303 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Piedmont Hospital Atlanta Georgia 30309 Recruiting
Emory University Hospital Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Josephs Hospital Atlanta Georgia 30342 Recruiting
Emory Decatur Hospital Decatur Georgia 30033 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
Northwestern Medicine Orland Park Orland Park Illinois 60462 Recruiting
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 Recruiting
Ascension Saint Vincent Indianapolis Hospital Indianapolis Indiana 46260 Recruiting
Norton Hospital Pavilion and Medical Campus Louisville Kentucky 40202 Recruiting
Norton Suburban Hospital and Medical Campus Louisville Kentucky 40207 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Massachusetts General Hospital Cancer Center Boston Massachusetts 02114 Recruiting
Baystate Medical Center Springfield Massachusetts 01199 Recruiting
UMass Memorial Medical Centre Worcester Massachusetts 01605 Recruiting
Washington University School of Medicine St Louis Missouri 63110 Recruiting
Nebraska Methodist Hospital Omaha Nebraska 68114 Recruiting
Womens Cancer Center of Nevada Las Vegas Nevada 89106 Recruiting
Sidney Kimmel Cancer Center Washington Township Sewell New Jersey 08080 Recruiting
Mount Sinai Chelsea New York New York 10011 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
Upstate Cancer Center Radiation Oncology at Oswego Oswego New York 13126 Recruiting
State University of New York Syracuse New York 13210 Recruiting
Upstate Cancer Center at Hill Radiation Oncology Syracuse New York 13210 Recruiting
Upstate Cancer Center at Verona Verona New York 13478 Recruiting
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
Duke Womens Cancer Care Raleigh Raleigh North Carolina 27607 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
Ohio State University Comprehensive Columbus Ohio 43210 Recruiting
UH Seidman Cancer Center Mentor Ohio 44060 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Providence Portland Medical Centre Portland Oregon 97213 Recruiting
Providence Saint Vincent Medical Center Portland Oregon 97225 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033 Recruiting
Thomas Jefferson University Philadelphia Pennsylvania 19107 Recruiting
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 Recruiting
Women and Infants Hospital Providence Rhode Island 02905 Recruiting
M.D. Anderson Cancer Center Houston Texas 77030 Recruiting
Farmington Health Centre Farmington Utah 84025 Recruiting
University of Utah Sugarhouse Health Centre Salt Lake City Utah 84106 Recruiting
Huntsman Cancer Institute University of Utah Salt Lake City Utah 84112 Recruiting
University of Vermont Medical Center Burlington Vermont 05401 Recruiting
University of Vermont and State Agricultural College Burlington Vermont 05405 Recruiting
University of Virginia Cancer Center Charlottesville Virginia 22908 Recruiting
Virginia Commonwealth University Richmond Virginia 23298 Recruiting
Swedish Medical Center First Hill Seattle Washington 98122 Recruiting
Saint Vincent Hospital Cancer Center Green Bay Green Bay Wisconsin 54301 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 41 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05640999, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 3, 2026 · Synced May 4, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05640999 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →