SPEARHEAD-3 Pediatric Study

ClinicalTrials.gov ID: NCT05642455

Public ClinicalTrials.gov record NCT05642455. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 23, 2026, 1:20 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2 Open Label, Basket Study to Assess the Safety, Tolerability and Anti-Tumor Activity of Afamitresgene Autoleucel in Pediatric Subjects With MAGE-A4 Positive Tumors

Study identification

NCT ID: NCT05642455
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: USWM CT, LLC; Industry
Enrollment: 20 participants

Conditions and interventions

Conditions

Interventions

Afamitresgene autoleucel Genetic

Genetic

Eligibility (public fields only)

Age range: 2 Years to 21 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 31, 2023
Primary completion: Sep 30, 2026
Completion: Jul 29, 2038
Last update posted: Feb 8, 2026

2023 – 2038

United States locations

U.S. sites: 10
U.S. states: 10
U.S. cities: 10

Facility	City	State	ZIP	Site status
Stanford University	Palo Alto	California	94305	Recruiting
National Institutes of Health	Bethesda	Maryland	20892	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	10065	Not yet recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Memorial Sloan Kettering Kids	New York	New York	10065	Not yet recruiting
Duke University School of Medicine	Durham	North Carolina	27710	Not yet recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Children's Hospital of Philedephia	Philadelphia	Pennsylvania	19104	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Not yet recruiting
University of Wisconsin Cancer Center	Madison	Wisconsin	53715	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05642455, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 8, 2026 · Synced Jul 23, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05642455 live on ClinicalTrials.gov.

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