ClinicalTrials.gov record
A Study to Learn How Well the Study Treatment Asundexian Works and How Safe it is Compared to Apixaban to Prevent Stroke or Systemic Embolism in People With Irregular and Often Rapid Heartbeat (Atrial Fibrillation), and at Risk for Stroke
ClinicalTrials.gov ID: NCT05643573
Public ClinicalTrials.gov record NCT05643573. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 11, 2026, 4:39 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, International, Randomized, Active Comparator-controlled, Double-blind, Double-dummy, Parallel-group, 2-arm, Phase 3 Study to Compare the Efficacy and Safety of the Oral FXIa Inhibitor Asundexian (BAY 2433334) With Apixaban for the Prevention of Stroke or Systemic Embolism in Male and Female Participants Aged 18 Years and Older With Atrial Fibrillation at Risk for Stroke
Study identification
- NCT ID
- NCT05643573
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Bayer
- Industry
- Enrollment
- 14,830 participants
Conditions and interventions
Interventions
- Apixaban Drug
- Apixaban matching placebo Drug
- Asundexian (BAY2433334) Drug
- Asundexian matching placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 4, 2022
- Primary completion
- Jan 30, 2024
- Completion
- Jan 30, 2024
- Last update posted
- Dec 8, 2024
2022 – 2024
United States locations
- U.S. sites
- 163
- U.S. states
- 37
- U.S. cities
- 147
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SEC Clinical Research | Dothan | Alabama | 36305 | — |
| Eastern Shore Research Institute, LLC | Fairhope, AL | Fairhope | Alabama | 36532 | — |
| Mobile Heart Specialists, PC | Mobile | Alabama | 36608 | — |
| University of South Alabama Medical Center | Mobile | Alabama | 36617 | — |
| Arkansas Cardiology | Little Rock | Little Rock | Arkansas | 72205 | — |
| Valley Clinical Trials, Inc. | Covina, CA | Covina | California | 91723 | — |
| Science 37 | Culver City | California | 90230 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| VA Long Beach Healthcare System | Long Beach | California | 90822 | — |
| VA Greater Los Angeles Healthcare System | West Los Angeles VA Medical Center - Cardiology Department | Los Angeles | California | 90073-1003 | — |
| Radin Cardiovascular Medical Group | Newport Beach | California | 92663 | — |
| Amicis Research Center | Northridge, CA | Northridge | California | 91324 | — |
| Cottage Health | Santa Barbara Cottage Hospital - Cardiology Department | Santa Barbara | California | 93102 | — |
| NorthBay Clinical Research, LLC | Santa Rosa, CA | Santa Rosa | California | 95405 | — |
| The Lundquist Institute | Cardiology Department | Torrance | California | 90502-2004 | — |
| Harbor - UCLA Medical Center | Torrance | California | 90502 | — |
| Blue Coast Research Center, LLC | Vista | California | 92081 | — |
| Interventional Cardiology Medical Group | West Hills, CA | West Hills | California | 91307 | — |
| University of Colorado Hospital - Cardiology | Aurora | Colorado | 80045 | — |
| South Denver Cardiology Associates, PC | Littleton | Colorado | 80120 | — |
| Cardiology Associates of Fairfield County, P.C. | Stamford, CT | Norwalk | Connecticut | 06851 | — |
| Integrity Clinical Research | Florida Premier Cardiology | Boynton Beach | Florida | 33437 | — |
| Integrity Clinical Research | Cardiology Associates of South Florida | Boynton Beach | Florida | 33472 | — |
| Cardiovascular & Vein Center of Florida | Bradenton, FL | Bradenton | Florida | 34209 | — |
| Nova Clinical Research | Brandenton, FL | Bradenton | Florida | 34209 | — |
| Clearwater Cardiovascular Associates | Clearwater, FL | Clearwater | Florida | 33756 | — |
| Cardiology Consultants, PA | Daytona Beach | Florida | 32114 | — |
| Cardiology Associates Research Company | Daytona Beach | Florida | 32117 | — |
| Integrity Clinical Research | Heller Heart Health | Delray Beach | Florida | 33446 | — |
| North Florida Foundation For Research And Education | Veterans Benefits Administration | Gainesville | Florida | 32608 | — |
| Indago Research and Health Center | Hialeah, FL | Hialeah | Florida | 33012 | — |
| Encore Research Group | Nature Coast Clinical Research - Inverness | Inverness | Florida | 34452 | — |
| University of Florida - Jacksonville | Jacksonville | Florida | 32209 | — |
| Heart Vein & Vascular | Longwood, FL | Longwood | Florida | 32779 | — |
| Life Spring Research | Miami, FL | Miami | Florida | 33130 | — |
| Southwest Florida Research | Naples, FL | Naples | Florida | 34102-8143 | — |
| Advanced Research for Health Improvement, LLC | Naples, FL | Naples | Florida | 34102 | — |
| Cardiology Partners Clinical Research Institute | Palm Beach Gardens Office | Palm Beach Gardens | Florida | 33410 | — |
| Baptist Heart and Vascular/Cardiology Consultants | Pensacola | Florida | 32503 | — |
| Peace River Cardiovascular Center | Port Charlotte, FL | Port Charlotte | Florida | 33592 | — |
| Encore Research Group | St. Johns Center for Clinical Research | Saint Augustine | Florida | 32081 | — |
| East Coast Institute for Research | St. Augustine, FL | Saint Augustine | Florida | 32086 | — |
| Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota, FL | Sarasota | Florida | 34239 | — |
| Cardiology Partners Clinical Research Institute | Wellington Office | Wellington | Florida | 33449 | — |
| St. Mary's Medical Center | West Palm Beach - Neurology Department | West Palm Beach | Florida | 33407-2495 | — |
| Morehouse School of Medicine | Clinical Research Centre | Atlanta | Georgia | 30303-3031 | — |
| NSC Cardiology | Johns Creek, GA | Cumming | Georgia | 30041 | — |
| Alta Pharmaceutical Research Center, LLC | Peachtree Corners | Georgia | 30092 | — |
| Atlanta Heart Specialists, LLC | Tucker | Georgia | 30084 | — |
| St. Luke's Health System | St. Luke's Clinic - Idaho Cardiology Associates | Meridian | Idaho | 83642 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Northshore Medical Center | Glenview | Illinois | 60026 | — |
| Affinity Health Research Institute | Oak Brook, IL | Oak Brook | Illinois | 60523 | — |
| Midwest Cardiovascular Research and Education Foundation | Elkhart, IN | Elkhart | Indiana | 46514 | — |
| Cardiovascular Research of Northwest Indiana, LLC. | Munster, IN | Hammond | Indiana | 46320 | — |
| IU Health Physicians Cardiology | Indianapolis | Indiana | 46202 | — |
| Reid Physician Associates | Cardiology Department | Richmond | Indiana | 47374 | — |
| Accellacare | Ames, IA | Ames | Iowa | 50010 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Kansas Nephrology Physicians, PA | Wichita | Kansas | 67226 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Baptist Health Medical Group - Louisville Cardiology | Louisville | Kentucky | 40207 | — |
| Research Integrity, LLC | Owensboro | Kentucky | 42303 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Ochsner Clinic Foundation | Baton Rouge | Louisiana | 70836 | — |
| Cardiovascular Associates Research, LLC | Covington | Louisiana | 70433 | — |
| Ochsner Medical Center - New Orleans | New Orleans | Louisiana | 70121 | — |
| Louisiana Heart Center Research - Slidell | Slidell | Louisiana | 70458 | — |
| Northeast Cardiology Associates | Bangor | Maine | 04401 | — |
| MaineHealth Maine Medical Center | Maine Medical Partners Cardiology | Scarborough | Maine | 04039 | — |
| LifeBridge Health | Sinai Hospital - Platelet and Thrombosis Research Department | Baltimore | Maryland | 21215 | — |
| Spectrum Clinical Research | Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Johns Hopkins Hospital/Health System | Baltimore | Maryland | 21287 | — |
| Johns Hopkins University School of Medicine | CAPRES | Columbia | Maryland | 21044 | — |
| Anderson Medical Group and Cardiology | Anderson Medical Research, LLC | Ft. Washington | Maryland | 20744 | — |
| Adventist HealthCare | White Oak Medical Center | Silver Spring | Maryland | 20904 | — |
| McLaren Health Care | McLaren Bay Region - Research Department | Bay City | Michigan | 48708 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| AA Medical Research Center | Flint, MI | Flint | Michigan | 48504 | — |
| Sparrow Clinical Research Institute | Sparrow Hospital - Clinical Research Department | Lansing | Michigan | 48912 | — |
| M Health Fairview | Maplewood | Minnesota | 55109 | — |
| Veterans Benefits Administration | Minneapolis VA Medical Center - Cardiology Department | Minneapolis | Minnesota | 55417 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Minneapolis Heart Institute | Saint Paul | Minnesota | 55102 | — |
| Jackson Heart Clinic | Jackson, MS | Jackson | Mississippi | 39216 | — |
| Cardiology Associates Research, LLC | Tupelo | Mississippi | 38801 | — |
| St. Louis Heart & Vascular, PC | St Louis | Missouri | 63136 | — |
| CHI Health Clinic Heart Institute - Grand Island | Grand Island | Nebraska | 68803 | — |
| Advanced Heart Care, LLC | Bridgewater, NJ | Bridgewater | New Jersey | 08807 | — |
| NJ Heart | Linden, NJ | Linden | New Jersey | 07036 | — |
| Garden State Heart Care | Manalapan | New Jersey | 07726 | — |
| Inspira Medical Centers | Clinical Research Office | Mullica Hill | New Jersey | 08062 | — |
| The Valley Hospital, Inc. | Ridgewood | New Jersey | 07450 | — |
| Cooper Specialty Care at Voorhees | Voorhees Township | New Jersey | 08043 | — |
| IMA Clinical Research | Warren, NJ | Warren Township | New Jersey | 07059 | — |
| Circuit Clinical/Crystal Run | Middletown | New York | 10941 | — |
| NYU Langone Health | NYU Langone Medical Associates Chelsea - Cardiovascular Research | New York | New York | 10001 | — |
| Division of Cardiovascular Research at Peconic Bay Med Ctr | Riverhead | New York | 11901 | — |
| Great Lakes Medical Research | Westfield, NY | Westfield | New York | 14787 | — |
| University of North Carolina at Chapel Hill | Cardiology Department | Chapel Hill | North Carolina | 27514 | — |
| Duke University | Duke Clinical Research Institute - Participant Research Operations | Durham | North Carolina | 27710-4000 | — |
| Duke Univ. Medical Center | Durham | North Carolina | 27710 | — |
| Medication Management | Greensboro - Cardiology | Greensboro | North Carolina | 27408 | — |
| Clinical Trials of America, Inc. | Mount Airy | North Carolina | 27030 | — |
| Lillestol Research LLC | Fargo, ND | Fargo | North Dakota | 58104 | — |
| Aultman | Aultman Hospital Main Campus - Clinical Trials | Canton | Ohio | 44710 | — |
| Kettering Health Network | Research Institute | Kettering | Ohio | 45429 | — |
| Rama Research LLC | Marion, OH | Marion | Ohio | 43302-6774 | — |
| ProMedica Toledo Hospital | Toledo | Ohio | 43615 | — |
| South Oklahoma Heart Research, LLC | Oklahoma City | Oklahoma | 73135 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Capital Area Research | Camp Hill, PA | Camp Hill | Pennsylvania | 17011 | — |
| Doylestown Hospital | Doylestown | Pennsylvania | 18901 | — |
| University of Pittsburgh Medical Center, Hamot | Clinical Trials and Research | Erie | Pennsylvania | 16507 | — |
| Pennsylvania State University College of Medicine | Hershey | Pennsylvania | 17033 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Einstein Healthcare Network | Philadelphia | Pennsylvania | 19141 | — |
| University of Pittsburgh Medical Center Health System | Pittsburgh | Pennsylvania | 15219 | — |
| Geisinger Community Medical Center | Scranton | Pennsylvania | 18510 | — |
| Geisinger Wyoming Valley Medical Center | Wilkes-Barre | Pennsylvania | 18711 | — |
| Main Line Health | Wynnewood | Pennsylvania | 19096 | — |
| Cardiology Consultants of Philadelphia | Yardley | Yardley | Pennsylvania | 19067 | — |
| Lifespan | The Miriam Hospital - Cardiovascular Research | Providence | Rhode Island | 02906 | — |
| AnMed Clinical Research | Anderson | South Carolina | 29621 | — |
| Medical University of South Carolina - Cardiology | Charleston | South Carolina | 29425 | — |
| Piedmont Research Partners LLC | Fort Mill | South Carolina | 29707 | — |
| Accellacare | Mt. Pleasant, SC | Ladson | South Carolina | 29456 | — |
| Carolina Heart Specialists | Lancaster, SC | Lancaster | South Carolina | 29720 | — |
| Rapid City Regional Hospital | Rapid City | South Dakota | 57701 | — |
| Sanford USD Medical Center | Sioux Falls | South Dakota | 57117 | — |
| Holston Medical Group - Bristol | Bristol | Tennessee | 37620 | — |
| Erlanger Health, Inc. | Chattanooga | Tennessee | 37403 | — |
| Stern Cardiovascular Center | Germantown | Tennessee | 38138 | — |
| Apex Research Foundation, LLC. | Jackson, TN | Jackson | Tennessee | 38301 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Cardiovascular Research of Knoxville | Powell | Tennessee | 37849 | — |
| PharmaTex Research, LLC | Amarillo | Texas | 79109 | — |
| Southwest Family Medicine Associates | Dallas, TX | Dallas | Texas | 75235 | — |
| Prime Revival Reserach Institute, LLC | Denton, TX | Denton | Texas | 76201 | — |
| David Turbay MD PLLC | El Paso | Texas | 79905 | — |
| Texas Health Research & Education Institute | Fort Worth | Texas | 76104 | — |
| Texas Health Physicians Group - Fort Worth | Fort Worth | Texas | 76107 | — |
| University of Texas Medical Branch at Galveston | Galveston | Texas | 77555-0587 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| TCR Institute | Kingwood | Texas | 77339 | — |
| North Dallas Research Associate | McKinney, TX | McKinney | Texas | 75069-1780 | — |
| North Texas Research Associates | McKinney | Texas | 75071 | — |
| Styde Research LLC | Plano, TX | Plano | Texas | 75093 | — |
| South Texas Cardiovascular Consultants, PLLC | San Antonio | Texas | 78201 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212-4740 | — |
| Mt. Olympus Medical Research | Sugar Land | Texas | 77479 | — |
| Northwest Houston Clinical Research, PLLC - Houston Heart Center | Tomball, TX | Tomball | Texas | 77375 | — |
| Tyler Cardiovascular Consultants | Tyler, TX | Tyler | Texas | 75701 | — |
| CHRISTUS Trinity | Mother Frances Louis and Peaches Owen Heart Hospital - Electrophysiology Clinic | Tyler | Texas | 75702 | — |
| Intermountain Healthcare | Cardiovascular Research Department | Murray | Utah | 84107 | — |
| Inova Fairfax Hospital - Fairfax | Fairfax | Virginia | 22031 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| York Clinical Research, LLC | Norfolk, VA | Norfolk | Virginia | 23504 | — |
| Hunter Holmes McGuire Veterans Affairs Medical Center | Richmond | Virginia | 23249-0001 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23284 | — |
| Sound Medical Research | Sound Medical Research of Port Orchard | Port Orchard | Washington | 98366 | — |
| Confluence Health | Wenatchee | Washington | 98801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 906 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05643573, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 8, 2024 · Synced May 11, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05643573 live on ClinicalTrials.gov.