Parent Study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOvel Anitbodies (SUPERNOVA Sub-study)
Public ClinicalTrials.gov record NCT05648110. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/III Randomized, Double-blind Study to Evaluate the Safety, Efficacy and Neutralizing Activity of AZD5156/AZD3152 for Pre-exposure Prophylaxis of COVID-19 in Participants With Conditions Causing Immune Impairment. Sub-study: Phase II Open Label Sub-study to Evaluate the Safety, PK, and Neutralizing Activity of AZD3152 for Pre-exposure Prophylaxis of COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
AZD3152, a single mAb, is being developed to have broad neutralizing activity across known SARS-CoV-2 variants of concern for pre-exposure prophylaxis of COVID-19. The aim of the Phase I/III study (Parent Study) will be to evaluate the safety, efficacy and neutralizing activity of AZD3152 compared with comparator for pre exposure prophylaxis of COVID-19, and separately evaluate the safety and PK of AZD5156, a combination of AZD3152 and AZD1061. Sub-study: This Phase II sub-study of SUPERNOVA will assess the safety, PK, and predicted neutralizing activity of AZD3152 compared with EVUSHELD for pre-exposure prophylaxis of COVID-19.
Study identification
- NCT ID
- NCT05648110
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 3,882 participants
Conditions and interventions
Conditions
Interventions
- AZD5156 (Parent study Sentinel Safety Cohort) Biological
- Placebo (Parent study Sentinel Safety Cohort) Biological
- EVUSHELD™ (Parent study Main Cohort) Biological
- AZD3152 (Parent study Main Cohort) Biological
- Placebo (Parent study Main Cohort) Biological
- AZD3152 (Sub-study) Biological
- AZD7442 - EVUSHELD™ (Sub-study) Biological
- AZD7442 (EVUSHELD™) (Sub-study) Immunocompromised participants offered AZD3152 Biological
Biological
Eligibility (public fields only)
- Age range
- 12 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2022 (Actual)
- Primary completion
- Mar 29, 2024 (Actual)
- Completion
- Feb 11, 2025 (Actual)
- Last update posted
- Jun 18, 2026
2022 – 2025
United States locations
- U.S. sites
- 130
- U.S. states
- 39
- U.S. cities
- 111
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35209 | — |
| Research Site | Birmingham | Alabama | 35215 | — |
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Glendale | Arizona | 85306 | — |
| Research Site | Mesa | Arizona | 85206 | — |
| Research Site | Mesa | Arizona | 85210 | — |
| Research Site | Tucson | Arizona | 85712 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Colton | California | 92324 | — |
| Research Site | La Mesa | California | 91942 | — |
| Research Site | Long Beach | California | 90815 | — |
| Research Site | Los Angeles | California | 90027 | — |
| Research Site | Modesto | California | 95350 | — |
| Research Site | Sacramento | California | 95817 | — |
| Research Site | Tustin | California | 92780 | — |
| Research Site | Westminster | California | 92683 | — |
| Research Site | Aurora | Colorado | 80014 | — |
| Research Site | Denver | Colorado | 80209 | — |
| Research Site | Denver | Colorado | 80246 | — |
| Research Site | Fort Collins | Colorado | 80525 | — |
| Research Site | New Haven | Connecticut | 06519 | — |
| Research Site | Washington D.C. | District of Columbia | 20007 | — |
| Research Site | Coral Gables | Florida | 33134 | — |
| Research Site | Fleming Island | Florida | 32003 | — |
| Research Site | Fort Myers | Florida | 33912 | — |
| Research Site | Hollywood | Florida | 33024 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Jacksonville | Florida | 32256 | — |
| Research Site | Lake Worth | Florida | 33462 | — |
| Research Site | Largo | Florida | 33777 | — |
| Research Site | Lauderdale Lakes | Florida | 33313 | — |
| Research Site | Leesburg | Florida | 34748 | — |
| Research Site | Medley | Florida | 33166 | — |
| Research Site | Miami | Florida | 33125 | — |
| Research Site | Miami | Florida | 33126 | — |
| Research Site | Miami | Florida | 33135 | — |
| Research Site | Miami | Florida | 33186 | — |
| Research Site | Miami Lakes | Florida | 33014 | — |
| Research Site | Miami Springs | Florida | 33166 | — |
| Research Site | North Miami Beach | Florida | 33162 | — |
| Research Site | Orlando | Florida | 32806 | — |
| Research Site | Ormond Beach | Florida | 32174 | — |
| Research Site | Port Orange | Florida | 32127 | — |
| Research Site | St. Petersburg | Florida | 33713 | — |
| Research Site | Winter Park | Florida | 32789 | — |
| Research Site | Atlanta | Georgia | 30342 | — |
| Research Site | Columbus | Georgia | 31904 | — |
| Research Site | Boise | Idaho | 83712 | — |
| Research Site | Burr Ridge | Illinois | 60527 | — |
| Research Site | Chicago | Illinois | 60612 | — |
| Research Site | Chicago | Illinois | 60640 | — |
| Research Site | Gurnee | Illinois | 60031 | — |
| Research Site | Evansville | Indiana | 47712 | — |
| Research Site | Evansville | Indiana | 47715 | — |
| Research Site | South Bend | Indiana | 46617 | — |
| Research Site | West Des Moines | Iowa | 50266 | — |
| Research Site | Overland Park | Kansas | 66204 | — |
| Research Site | Wichita | Kansas | 67214 | — |
| Research Site | Bowling Green | Kentucky | 42101 | — |
| Research Site | Lexington | Kentucky | 40503 | — |
| Research Site | Lexington | Kentucky | 40509 | — |
| Research Site | Lake Charles | Louisiana | 70605 | — |
| Research Site | Metairie | Louisiana | 70006 | — |
| Research Site | New Orleans | Louisiana | 70119 | — |
| Research Site | Baltimore | Maryland | 21287 | — |
| Research Site | Boston | Massachusetts | 02115 | — |
| Research Site | Boston | Massachusetts | 02215 | — |
| Research Site | Methuen | Massachusetts | 01844 | — |
| Research Site | Springfield | Massachusetts | 01107 | — |
| Research Site | Worcester | Massachusetts | 01655 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Farmington Hills | Michigan | 48334 | — |
| Research Site | Grand Rapids | Michigan | 49525 | — |
| Research Site | Novi | Michigan | 48377 | — |
| Research Site | Saint Clair Shores | Michigan | 48081 | — |
| Research Site | Minneapolis | Minnesota | 55446 | — |
| Research Site | Jefferson City | Missouri | 65109 | — |
| Research Site | Kansas City | Missouri | 64114 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | St Louis | Missouri | 63131 | — |
| Research Site | Missoula | Montana | 59808 | — |
| Research Site | Lincoln | Nebraska | 68516 | — |
| Research Site | Las Vegas | Nevada | 89119 | — |
| Research Site | Portsmouth | New Hampshire | 03801 | — |
| Research Site | Hackensack | New Jersey | 07601 | — |
| Research Site | Albuquerque | New Mexico | 87109 | — |
| Research Site | Buffalo | New York | 14202 | — |
| Research Site | Ridgewood | New York | 11385 | — |
| Research Site | Rochester | New York | 14607 | — |
| Research Site | Rochester | New York | 14642 | — |
| Research Site | Charlotte | North Carolina | 28208 | — |
| Research Site | Durham | North Carolina | 27710 | — |
| Research Site | Monroe | North Carolina | 28112 | — |
| Research Site | Morehead City | North Carolina | 28557 | — |
| Research Site | Wilmington | North Carolina | 28403 | — |
| Research Site | Cincinnati | Ohio | 45267 | — |
| Research Site | Westlake | Ohio | 44145 | — |
| Research Site | Allentown | Pennsylvania | 18103 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Harrisburg | Pennsylvania | 17110 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Philadelphia | Pennsylvania | 19107 | — |
| Research Site | Pittsburgh | Pennsylvania | 15232 | — |
| Research Site | Providence | Rhode Island | 02903 | — |
| Research Site | Myrtle Beach | South Carolina | 29572 | — |
| Research Site | North Charleston | South Carolina | 29405 | — |
| Research Site | Rock Hill | South Carolina | 29732 | — |
| Research Site | Spartanburg | South Carolina | 29303 | — |
| Research Site | Knoxville | Tennessee | 37909 | — |
| Research Site | Austin | Texas | 78745 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | El Paso | Texas | 79925 | — |
| Research Site | Houston | Texas | 77054 | — |
| Research Site | Houston | Texas | 77065 | — |
| Research Site | Houston | Texas | 77070 | — |
| Research Site | Houston | Texas | 77081 | — |
| Research Site | Houston | Texas | 77089 | — |
| Research Site | Kingwood | Texas | 77339 | — |
| Research Site | Mesquite | Texas | 75150 | — |
| Research Site | San Angelo | Texas | 76904 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | Shenandoah | Texas | 77384 | — |
| Research Site | Layton | Utah | 84041 | — |
| Research Site | Salt Lake City | Utah | 84115 | — |
| Research Site | Annandale | Virginia | 22003 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Norfolk | Virginia | 23507 | — |
| Research Site | Olympia | Washington | 98506 | — |
| Research Site | Seattle | Washington | 98109 | — |
| Research Site | Madison | Wisconsin | 53715 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 85 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05648110, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 18, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05648110 live on ClinicalTrials.gov.