Left vs Left Randomized Clinical Trial

ClinicalTrials.gov ID: NCT05650658

Public ClinicalTrials.gov record NCT05650658. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Jul 21, 2026, 6:03 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical Trial

Study identification

NCT ID: NCT05650658
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Baylor College of Medicine; Other
Enrollment: 2,136 participants

Conditions and interventions

Conditions

Interventions

His/LBBP Device
BiVP Device

Device

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 12, 2023
Primary completion: Jun 29, 2029
Completion: Jun 29, 2029
Last update posted: Oct 1, 2025

2023 – 2029

United States locations

U.S. sites: 57
U.S. states: 24
U.S. cities: 49

Facility	City	State	ZIP	Site status
Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ	Gilbert	Arizona	85297	Recruiting
University of Arizona College of Medicine- Phoenix	Tucson	Arizona	85719	Recruiting
University of Arkansas for Medical Sciences (UAMS)	Little Rock	Arkansas	72205	Recruiting
University of California San Diego	La Jolla	California	92093	Recruiting
University of Colorado (Anschutz Medical Campus)	Denver	Colorado	80217	Recruiting
South Denver Cardiology Associates	Littleton	Colorado	80124	Recruiting
Hartford Hospital	Hartford	Connecticut	06102	Recruiting
Yale University	New Haven	Connecticut	06511	Recruiting
Heart Rhythm Solutions	Davie	Florida	33328	Recruiting
University of Florida Jacksonville	Jacksonville	Florida	32211	Not yet recruiting
Mount Sinai Medical Center of Florida, Inc.	Miami Beach	Florida	33140	Not yet recruiting
Cleveland Clinic Florida	Palm Beach Gardens	Florida	33418	Recruiting
Florida Heart and Vascular, LLC dba Florida Heart Rhythm Specialist, PLLC	South Pasadena	Florida	33707	Not yet recruiting
University of South Florida	Tampa	Florida	33613	Recruiting
Rush University	Chicago	Illinois	60612	Recruiting
University of Chicago	Chicago	Illinois	60637	Recruiting
Northwestern University	Evanston	Illinois	60208	Recruiting
CIS Clinical Research Corporation	Naperville	Illinois	60540	Enrolling by invitation
Trustees of Indiana University	Indianapolis	Indiana	46202	Recruiting
Baptist Health Louisville	Louisville	Kentucky	40207	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
HMH Hospitals Corporation	Hackensack	New Jersey	07601	Recruiting
Virtua Health	Marlton	New Jersey	08053	Recruiting
Newark Beth Israel Medical Center	Newark	New Jersey	07112	Recruiting
The Valley Hospital, Inc.	Ridgewood	New Jersey	07450	Recruiting
Lovelace Medical Center	Albuquerque	New Mexico	87102	Recruiting
Weill Cornell Medicine	New York	New York	10021	Recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
Columbia University Medical Center/New York-Presbyterian Hospital (CUMC/NYPH)	New York	New York	10032	Not yet recruiting
MH Mission Hospital LLLP- Asheville Cardiology Associates	Asheville	North Carolina	28803	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
Novant Health	Charlotte	North Carolina	28204	Recruiting
The Christ Hospital	Cincinnati	Ohio	45219	Recruiting
The MetroHealth System	Cleveland	Ohio	44109	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
St. Luke's University Health Network	Allentown	Pennsylvania	18015	Recruiting
Lehigh Valley Hospital Inc.	Allentown	Pennsylvania	18103	Recruiting
Penn Medicine Lancaster General	Lancaster	Pennsylvania	17603	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Allegheny-Singer Research Institute	Pittsburgh	Pennsylvania	15212	Recruiting
University of Pittsburg	Pittsburgh	Pennsylvania	15213	Recruiting
Geisinger Commonwealth School of Medicine	Scranton	Pennsylvania	18510	Recruiting
Medical University of South Carolina (MUSC)	Charleston	South Carolina	29425	Recruiting
Prisma Health-Upstate	Greenville	South Carolina	29605	Not yet recruiting
Texas Health Research & Education Institute	Arlington	Texas	76011	Not yet recruiting
Baylor College of Medicine	Houston	Texas	77030	Recruiting
St. Mark's Hospital	Salt Lake City	Utah	84124	Recruiting
University of Vermont	Burlington	Vermont	05402	Recruiting
University of Virginia Health System	Charlottesville	Virginia	22908	Recruiting
Inova Heart and Vascular Institute	Falls Church	Virginia	22042	Recruiting
Sentara Healthcare	Newport News	Virginia	23606	Recruiting
Virginia Commonwealth University	Richmond	Virginia	23284	Recruiting
University of Washington	Seattle	Washington	98195	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05650658, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 1, 2025 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05650658 live on ClinicalTrials.gov.

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