Left vs Left Randomized Clinical Trial
Public ClinicalTrials.gov record NCT05650658. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs Biventricular Pacing With a Left Ventricular Epicardial Lead in Patients With Heart Failure (HF) With Left Ventricular Ejection Fraction (LVEF)≤50% and With Either a Wide QRS Complex (>130 ms) or With/Anticipated >40% Pacing Randomized Clinical Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The investigators aim to prospectively test the comparative effectiveness of His or Left bundle branch pacing in relation to patient centered outcomes (quality of life, physical activity, heart failure hospitalization, mortality) and comparative safety in relation to device-related complications and re-interventions (e.g., lead dislodgement, infection) relative to standard of care biventricular pacing in patients with heart failure due to left ventricular systolic dysfunction (LVEF≤50%) and with either a wide QRS (≥130 ms) or with/anticipated \>40% pacing who are already receiving current standard heart failure pharmacological therapy.
Study identification
- NCT ID
- NCT05650658
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 2,136 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 12, 2023
- Primary completion
- Jun 29, 2029
- Completion
- Jun 29, 2029
- Last update posted
- Oct 1, 2025
2023 – 2029
United States locations
- U.S. sites
- 57
- U.S. states
- 24
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mercy Gilbert & Chandler Regional Medical Centers, Gilbert AZ | Gilbert | Arizona | 85297 | Recruiting |
| University of Arizona College of Medicine- Phoenix | Tucson | Arizona | 85719 | Recruiting |
| University of Arkansas for Medical Sciences (UAMS) | Little Rock | Arkansas | 72205 | Recruiting |
| University of California San Diego | La Jolla | California | 92093 | Recruiting |
| University of Colorado (Anschutz Medical Campus) | Denver | Colorado | 80217 | Recruiting |
| South Denver Cardiology Associates | Littleton | Colorado | 80124 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Yale University | New Haven | Connecticut | 06511 | Recruiting |
| Heart Rhythm Solutions | Davie | Florida | 33328 | Recruiting |
| University of Florida Jacksonville | Jacksonville | Florida | 32211 | Not yet recruiting |
| Mount Sinai Medical Center of Florida, Inc. | Miami Beach | Florida | 33140 | Not yet recruiting |
| Cleveland Clinic Florida | Palm Beach Gardens | Florida | 33418 | Recruiting |
| Florida Heart and Vascular, LLC dba Florida Heart Rhythm Specialist, PLLC | South Pasadena | Florida | 33707 | Not yet recruiting |
| University of South Florida | Tampa | Florida | 33613 | Recruiting |
| Rush University | Chicago | Illinois | 60612 | Recruiting |
| University of Chicago | Chicago | Illinois | 60637 | Recruiting |
| Northwestern University | Evanston | Illinois | 60208 | Recruiting |
| CIS Clinical Research Corporation | Naperville | Illinois | 60540 | Enrolling by invitation |
| Trustees of Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| Baptist Health Louisville | Louisville | Kentucky | 40207 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| HMH Hospitals Corporation | Hackensack | New Jersey | 07601 | Recruiting |
| Virtua Health | Marlton | New Jersey | 08053 | Recruiting |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | Recruiting |
| The Valley Hospital, Inc. | Ridgewood | New Jersey | 07450 | Recruiting |
| Lovelace Medical Center | Albuquerque | New Mexico | 87102 | Recruiting |
| Weill Cornell Medicine | New York | New York | 10021 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Columbia University Medical Center/New York-Presbyterian Hospital (CUMC/NYPH) | New York | New York | 10032 | Not yet recruiting |
| MH Mission Hospital LLLP- Asheville Cardiology Associates | Asheville | North Carolina | 28803 | Recruiting |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | Recruiting |
| Novant Health | Charlotte | North Carolina | 28204 | Recruiting |
| The Christ Hospital | Cincinnati | Ohio | 45219 | Recruiting |
| The MetroHealth System | Cleveland | Ohio | 44109 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| St. Luke's University Health Network | Allentown | Pennsylvania | 18015 | Recruiting |
| Lehigh Valley Hospital Inc. | Allentown | Pennsylvania | 18103 | Recruiting |
| Penn Medicine Lancaster General | Lancaster | Pennsylvania | 17603 | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Allegheny-Singer Research Institute | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| University of Pittsburg | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Geisinger Commonwealth School of Medicine | Scranton | Pennsylvania | 18510 | Recruiting |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | Recruiting |
| Prisma Health-Upstate | Greenville | South Carolina | 29605 | Not yet recruiting |
| Texas Health Research & Education Institute | Arlington | Texas | 76011 | Not yet recruiting |
| Baylor College of Medicine | Houston | Texas | 77030 | Recruiting |
| St. Mark's Hospital | Salt Lake City | Utah | 84124 | Recruiting |
| University of Vermont | Burlington | Vermont | 05402 | Recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | Recruiting |
| Inova Heart and Vascular Institute | Falls Church | Virginia | 22042 | Recruiting |
| Sentara Healthcare | Newport News | Virginia | 23606 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23284 | Recruiting |
| University of Washington | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 14 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05650658, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 1, 2025 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05650658 live on ClinicalTrials.gov.