A Study Assessing Rocatinlimab (AMG 451) Monotherapy in Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)
Public ClinicalTrials.gov record NCT05651711. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, 24-week, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety and Tolerability of Rocatinlimab (AMG 451) Monotherapy in Adult Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Horizon)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The co-primary objectives of the study are to: * Evaluate the efficacy of rocatinlimab compared with placebo at Week 24, assessed using Validated Investigator's Global Assessment for Atopic Dermatitis (vIGA-AD). * Evaluate the efficacy of rocatinlimab compared with placebo at Week 24, assessed using Eczema Area and Severity Index (EASI).
Study identification
- NCT ID
- NCT05651711
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 726 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 14, 2022 (Actual)
- Primary completion
- Jun 5, 2024 (Actual)
- Completion
- Aug 27, 2024 (Actual)
- Last update posted
- Jun 26, 2026
2022 – 2024
United States locations
- U.S. sites
- 69
- U.S. states
- 26
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Solutions of Arizona, PC | Litchfield Park | Arizona | 85340 | — |
| Center for Dermatology and Plastic Surgery | Scottsdale | Arizona | 85260 | — |
| Clinical Trials Institute of Northwest Arkansas | Fayetteville | Arkansas | 72703 | — |
| Burke Pharmaceutical Research | Hot Springs | Arkansas | 71913 | — |
| Velocity Clinical Research Chula Vista | Chula Vista | California | 91911 | — |
| West Coast Research LLC | Dublin | California | 94568 | — |
| California Dermatology and Clinical Research Institute | Encinitas | California | 92024 | — |
| Center for Dermatology Clinical Research Inc | Fremont | California | 94538 | — |
| Velocity Clinical Research - San Diego | La Mesa | California | 91942 | — |
| Velocity Clinical Research - North Hollywood | North Hollywood | California | 91606 | — |
| Cura Clinical Research | Palmdale | California | 93551 | — |
| University of California at San Francisco, Dermatology Clinic at Mount Zion | San Francisco | California | 94115 | — |
| Clinical Science Institute | Santa Monica | California | 90404 | — |
| Clarity Dermatology | Castle Rock | Colorado | 80109 | — |
| Velocity Clinical Research - Denver | Denver | Colorado | 80209 | — |
| Foxhall Research Center | Washington D.C. | District of Columbia | 20016 | — |
| Renaissance Research and Medical Group | Cape Coral | Florida | 33991 | — |
| Driven Research LLC | Coral Gables | Florida | 33134 | — |
| Saint Jude Clinical Research | Doral | Florida | 33172 | — |
| Direct Helpers Research Center | Hialeah | Florida | 33012 | — |
| Glick Skin Institute | Margate | Florida | 33063 | — |
| Miami Dade Medical Research Institute, LLC | Miami | Florida | 33176 | — |
| Innovation Medical Research Center Inc | Palmetto Bay | Florida | 33157 | — |
| University of South Florida Health Morsani Center for Advanced Healthcare | Tampa | Florida | 33612 | — |
| Advanced Medical Research PC | Sandy Springs | Georgia | 30328 | — |
| Sneeze, Wheeze, and Itch Associates, LLC | Normal | Illinois | 61761 | — |
| The South Bend Clinic LLP | South Bend | Indiana | 46617 | — |
| Options Research Group LLC | West Lafayette | Indiana | 47906 | — |
| Dermatology and Skin Cancer Center of Overland Park | Overland Park | Kansas | 66223 | — |
| DS Research | Louisville | Kentucky | 40241 | — |
| Kentucky Advanced Medical Research LLC | Murray | Kentucky | 42071 | — |
| MetroBoston Clinical Partners | Brighton | Massachusetts | 02135 | — |
| Wendy Sadoff MD Dermatology PC | Farmington Hills | Michigan | 48334 | — |
| Revival Research Institute LLC | Troy | Michigan | 48084 | — |
| Somerset Skin Centre | Troy | Michigan | 48084 | — |
| Advanced Dermatology of the Midlands | Omaha | Nebraska | 68144 | — |
| James Del Rosso Dermatology Research | Las Vegas | Nevada | 89117 | — |
| Skin Cancer and Dermatology Institute | Reno | Nevada | 89509 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03766 | — |
| Weiss Medical | Riverdale | New Jersey | 07457 | — |
| Corning Center For Clinical Research | Horseheads | New York | 14845 | — |
| Forest Hills Dermatology Group | Kew Gardens | New York | 11415 | — |
| Crystal Run Healthcare | Monroe | New York | 10950 | — |
| Ace Clinical Trials | New York | New York | 10022 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| OptiSkin Medical | New York | New York | 10128 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Duke South Durham | Durham | North Carolina | 27713 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| Bernstein Clinical Research Center LLC | Cincinnati | Ohio | 45236 | — |
| The Ohio State University Dermatology East | Gahanna | Ohio | 43230 | — |
| Velocity Clinical Research - Grants Pass | Grants Pass | Oregon | 97527 | — |
| Oregon Medical Research Center | Portland | Oregon | 97223 | — |
| Asthma and Allergy Physicians of Rhode Island Clinical Research Institute | Warwick | Rhode Island | 02886 | — |
| Bellaire Dermatology Associates | Bellaire | Texas | 77401 | — |
| US Dermatology Partners Cedar Park | Cedar Park | Texas | 78613 | — |
| Alina Clinical Trials, LLC | Dallas | Texas | 75225 | — |
| Zenos Clinical Research, LLC | Dallas | Texas | 75230 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| MedCare Pharma - Houston | Houston | Texas | 77037 | — |
| FMCScience LLC | Lampasas | Texas | 76550 | — |
| Epic Clinical Research Incorporated | Lewisville | Texas | 75057 | — |
| Sienna Dermatology Research | Missouri City | Texas | 77459 | — |
| Texas Dermatology and Laser Specialists | San Antonio | Texas | 78218 | — |
| Andante Research | San Antonio | Texas | 78229 | — |
| Dermatology Clinical Research Center of San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah MidValley Dermatology | Murray | Utah | 84107 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23507 | — |
| MultiCare Institute for Research and Innovation | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05651711, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 26, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05651711 live on ClinicalTrials.gov.