ClinicalTrials.gov record
A Study to Learn About a New Medicine Called Vepdegestrant (ARV-471, PF-07850327) in People Who Have Advanced Metastatic Breast Cancer
ClinicalTrials.gov ID: NCT05654623
Public ClinicalTrials.gov record NCT05654623. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 12:50 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 3, RANDOMIZED, OPEN-LABEL, MULTICENTER TRIAL OF ARV-471 (PF-07850327) VS FULVESTRANT IN PARTICIPANTS WITH ESTROGEN RECEPTOR-POSITIVE, HER2-NEGATIVE ADVANCED BREAST CANCER WHOSE DISEASE PROGRESSED AFTER PRIOR ENDOCRINE BASED TREATMENT FOR ADVANCED DISEASE (VERITAC-2)
Study identification
- NCT ID
- NCT05654623
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 624 participants
Conditions and interventions
Conditions
Interventions
- ARV-471 Drug
- Fulvestrant Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2023
- Primary completion
- Jan 30, 2025
- Completion
- May 14, 2028
- Last update posted
- Mar 17, 2026
2023 – 2028
United States locations
- U.S. sites
- 87
- U.S. states
- 15
- U.S. cities
- 72
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Cancer Associates for Research and Excellence, Inc. (cCARE) | Encinitas | California | 92024 | — |
| Orange Coast Memorial Medical Center | Fountain Valley | California | 92708 | — |
| California Cancer Associates for Research and Excellence | Fresno | California | 93720 | — |
| Providence Queen of the Valley Medical Center | Napa | California | 94558 | — |
| California Cancer Associates for Research and Excellence | San Marcos | California | 92069 | — |
| Olive View-UCLA Medical Center | Sylmar | California | 91342 | — |
| Smilow Cancer Hospital Care Center at Fairfield | Fairfield | Connecticut | 06824 | — |
| Smilow Cancer Hospital at Yale-New Haven | New Haven | Connecticut | 06510 | — |
| Yale-New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Smilow Cancer Hospital Care Center at North Haven | North Haven | Connecticut | 06473 | — |
| Smilow Cancer Hospital Care Center at Trumbull | Trumbull | Connecticut | 06611 | — |
| Florida Cancer Specialists | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists BON | Bonita Springs | Florida | 34135 | — |
| Florida Cancer Specialists BCC | Bradenton | Florida | 34205 | — |
| Florida Cancer Specialists LRS | Bradenton | Florida | 34211 | — |
| Florida Cancer Specialists | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists NFM | Cape Coral | Florida | 33909 | — |
| Morton Plant Hospital - BayCare Health System | Clearwater | Florida | 33756 | — |
| Florida Cancer Specialists | Clearwater | Florida | 33761 | — |
| Florida Cancer Specialists | Daytona Beach | Florida | 32117 | — |
| Florida Cancer Specialists COL | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists GLO | Fort Myers | Florida | 33908 | — |
| Florida Cancer Specialists | Gainesville | Florida | 32605 | — |
| Lakeland Regional Cancer Center | Lakeland | Florida | 33805 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialists | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialist And Research Institute | N. Venice | Florida | 34275 | — |
| Florida Cancer Specialists NGD | Naples | Florida | 34102 | — |
| Florida Cnacer Specialists | North Port | Florida | 34286 | — |
| Florida Cancer Specialists | Ocala | Florida | 34474 | — |
| Florida Cancer Specialists | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists PCH | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists SAC | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists SAD | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists | Stuart | Florida | 34994 | — |
| Florida Cancer Specialists | Tampa | Florida | 33607 | — |
| Florida Cancer Specialists | Tavares | Florida | 32778 | — |
| Florida Cancer Specialists | The Villages | Florida | 32159 | — |
| Florida Cancer Specialist | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists | Vero Beach | Florida | 32960 | — |
| Florida Cancer Specialists | Wellington | Florida | 33414 | — |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | — |
| Florida Cancer Specialists | Winter Park | Florida | 32789 | — |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | — |
| Norton Cancer Institute - Downtown | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute, Downtown | Louisville | Kentucky | 40202 | — |
| Norton Hospital | Louisville | Kentucky | 40202 | — |
| Norton Cancer Institute, St Matthews Campus | Louisville | Kentucky | 40207 | — |
| Norton Women's & Children's Hospital | Louisville | Kentucky | 40207 | — |
| Norton Brownsboro Hospital | Louisville | Kentucky | 40241 | — |
| Norton Cancer Institute, Brownsboro Hospital Campus | Louisville | Kentucky | 40241 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Louisiana State University Health Sciences Shreveport | Shreveport | Louisiana | 71103 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| Mercy Clinic Oncology and Hematology | Ballwin | Missouri | 63011 | — |
| Saint Luke's Cancer Institute | Kansas City | Missouri | 64111 | — |
| Mercy Research - David C. Pratt Cancer Center | St Louis | Missouri | 63141 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| MSK Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| MSK Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering - Bergen | Montvale | New Jersey | 07645 | — |
| Hematology Oncology Associates of CNY | Camillus | New York | 13031 | — |
| MSK Commack | Commack | New York | 11725 | — |
| Hematology-Oncology Associates of Central New York, PC | East Syracuse | New York | 13057 | — |
| MSK Westchester | Harrison | New York | 10604 | — |
| R.J. Zuckerberg Cancer Center | Lake Success | New York | 11042 | — |
| Northern Westchester Hospital | Mount Kisco | New York | 10549 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| MSK Evelyn H. Lauder Breast and Imaging Center | New York | New York | 10065 | — |
| Hematology Oncology Associates of Rockland | Nyack | New York | 10960 | — |
| Phelps Hospital | Sleepy Hollow | New York | 10591 | — |
| MSK Nassau | Uniondale | New York | 11553 | — |
| Cancer Centers of Southwest Oklahoma | Lawton | Oklahoma | 73505 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22903 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| UVA Breast Care Center | Charlottesville | Virginia | 22911 | — |
| Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia | 23116 | — |
| Bon Secours St. Francis Medical Center | Midlothian | Virginia | 23114 | — |
| Bon Secours St. Mary's Hospital | Richmond | Virginia | 23226 | — |
| Providence Regional Cancer System - Aberdeen | Aberdeen | Washington | 98520 | — |
| Providence Regional Cancer System- Centralia | Centralia | Washington | 98531 | — |
| Providence Regional Cancer System - Lacey | Lacey | Washington | 98503 | — |
| UW Medicine Valley Medical Center | Renton | Washington | 98055 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 225 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05654623, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05654623 live on ClinicalTrials.gov.