A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure
Public ClinicalTrials.gov record NCT05659264. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1, Adaptive, Open-Label, Single Ascending Dose to Single-Blind, Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-0184 in Participants With Chronic Heart Failure
Study identification
- NCT ID
- NCT05659264
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- ModernaTX, Inc.
- Industry
- Enrollment
- 48 participants
Conditions and interventions
Conditions
Interventions
- mRNA-0184 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 4, 2022
- Primary completion
- Dec 16, 2024
- Completion
- Dec 16, 2024
- Last update posted
- Mar 16, 2025
2022 – 2024
United States locations
- U.S. sites
- 5
- U.S. states
- 3
- U.S. cities
- 4
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology PC | Birmingham | Alabama | 35211 | — |
| University of Alabama at Birmingham: The Kirklin Clinic | Birmingham | Alabama | 35233 | — |
| University of Florida | Gainesville | Florida | 32608 | — |
| Jacksonville Center For Clinical Research - ERN - PPDS | Jacksonville | Florida | 32216 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05659264, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 16, 2025 · Synced Jun 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05659264 live on ClinicalTrials.gov.