Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)
Public ClinicalTrials.gov record NCT05660538. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Double-blind, Active-controlled, Dose-ranging, Parallel-design Study of the Efficacy and Safety of VX-548 in Subjects With Painful Diabetic Peripheral Neuropathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of VX-548 doses in treating Painful DPN.
Study identification
- NCT ID
- NCT05660538
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 194 participants
Conditions and interventions
Conditions
Interventions
- Suzetrigine Drug
- Pregabalin Drug
- Placebo (matched to SUZ) Drug
- Placebo (matched to pregabalin) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 19, 2022
- Primary completion
- Oct 11, 2023
- Completion
- Oct 24, 2023
- Last update posted
- Jun 30, 2025
2022 – 2023
United States locations
- U.S. sites
- 50
- U.S. states
- 25
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pinnacle Research Group, LLC | Anniston | Alabama | 36207 | — |
| Synexus Clinical Research US - Birmingham | Birmingham | Alabama | 35211 | — |
| Synexus Clinical Research US - Phoenix West | Phoenix | Arizona | 85020 | — |
| Velocity Clinical Research - Banning | Banning | California | 92220 | — |
| Long Beach Clinical Trials Services, Inc. | Long Beach | California | 90806 | — |
| University Clinical Investigators | Tustin | California | 92780 | — |
| Lynn Institute of the Rockies | Colorado Springs | Colorado | 80918 | — |
| Fleming Island Center for Clinical Research | Fleming Island | Florida | 32003 | — |
| AMR Fort Myers (The Clinical Study Center) | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research - Hallandale Beach | Hallandale | Florida | 33009-4427 | — |
| Westside Center for Clinical Research | Jacksonville | Florida | 32205 | — |
| Accel Research Sites - Tampa | Largo | Florida | 33777 | — |
| Accel Research Sites - Maitland | Maitland | Florida | 32751 | — |
| Suncoast Research Associates | Miami | Florida | 33137 | — |
| Synexus - Orlando | Orlando | Florida | 32806-1041 | — |
| Synexus - The Villages | The Villages | Florida | 32162-7116 | — |
| Accel Research Sites - Neurostudies | Decatur | Georgia | 30030 | — |
| Velocity Clinical Research - Boise (Advanced Clinical Research) | Meridian | Idaho | 83642 | — |
| Healthcare Research Network - Chicago | Flossmoor | Illinois | 60422 | — |
| Synexus Clinical Research - Evansville | Evansville | Indiana | 47714 | — |
| AMR El Dorado | El Dorado | Kansas | 67042 | — |
| AMR Newton | Newton | Kansas | 67114 | — |
| AMR Wichita East, KS | Wichita | Kansas | 67207 | — |
| Clinical Trials of America, LLC | Monroe | Louisiana | 71201 | — |
| Brigham and Women's Hospital (BWH) - Translational Pain Research | Boston | Massachusetts | 02115 | — |
| Boston Neuro Research Center, LLC | North Dartmouth | Massachusetts | 02747 | — |
| Boston PainCare Center | Waltham | Massachusetts | 02451 | — |
| Revival Research Institute | Dearborn | Michigan | 48126 | — |
| StudyMetrix Research, LLC | City of Saint Peters | Missouri | 63303-3041 | — |
| Healthcare Research Network - Hazelwood | Hazelwood | Missouri | 63042 | — |
| AMR Kansas City | Kansas City | Missouri | 64114-4866 | — |
| Synexus Clinical Research US - St. Louis | St Louis | Missouri | 63141 | — |
| Synexus Clinical Research - Henderson | Henderson | Nevada | 89052 | — |
| Hassman Research Institute | Berlin | New Jersey | 08009 | — |
| Synexus Clinical Research- New York | New York | New York | 10017 | — |
| Carolina Institute for Clinical Research | Fayetteville | North Carolina | 28303 | — |
| Triad Clinical Trials | Greensboro | North Carolina | 27410 | — |
| The Center for Clinical Research | Winston-Salem | North Carolina | 27103 | — |
| Synexus - Cincinnati | Cincinnati | Ohio | 45236 | — |
| Velocity Clinical Research - Cleveland | Cleveland | Ohio | 44122 | — |
| Velocity Clinical Research - Medford | Medford | Oregon | 97504 | — |
| Velocity Clinical Research - Providence | East Greenwich | Rhode Island | 02818 | — |
| Synexus Clinical Research- Anderson | Anderson | South Carolina | 29621 | — |
| Clinical Trials of South Carolina - Charleston | Charleston | South Carolina | 29406 | — |
| South Carolina Clinical Research | Orangeburg | South Carolina | 29118 | — |
| Inquest Clinical Research | Baytown | Texas | 77521 | — |
| Synexus - Dallas | Dallas | Texas | 75234-7858 | — |
| Diabetes & Glandular Disease Clinic, P.A | San Antonio | Texas | 78229-4801 | — |
| Wasatch Clinical Research | Salt Lake City | Utah | 84107 | — |
| Northwest Clinical Research Center (NWCRC) | Bellevue | Washington | 98007-4209 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05660538, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 30, 2025 · Synced Sep 24, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05660538 live on ClinicalTrials.gov.