Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus
Public ClinicalTrials.gov record NCT05669599. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized, Placebo-controlled, Double-blind, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study aims to compare and assess the dose response of 3 selected doses of maridebart cafraglutide compared with placebo, on inducing and maintaining weight loss from baseline at Week 52 in participants with overweight or obesity without diabetes mellitus (Cohort A) and in participants with overweight or obesity with Type 2 diabetes mellitus (Cohort B).
Study identification
- NCT ID
- NCT05669599
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 592 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 17, 2023
- Primary completion
- Oct 7, 2024
- Completion
- Dec 15, 2025
- Last update posted
- Jan 19, 2026
2023 – 2025
United States locations
- U.S. sites
- 29
- U.S. states
- 16
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alliance for Multispecialty Research Mobile | Mobile | Alabama | 36608 | — |
| Foothills Research Center | Phoenix | Arizona | 85044 | — |
| HonorHealth | Scottsdale | Arizona | 85258 | — |
| Ark Clinical Research- Long Beach | Long Beach | California | 90815 | — |
| Ark Clinical Research- Tustin | Tustin | California | 92780 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Diablo Clinical Research | Walnut Creek | California | 94598 | — |
| Alliance for Multispecialty Research Miami | Coral Gables | Florida | 33134 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| East-West Medical Research | Honolulu | Hawaii | 96814 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Alliance for Multispecialty Research Newton | Newton | Kansas | 67114 | — |
| Louisville Metabolic and Atherosclerosis Research Center | Louisville | Kentucky | 40213 | — |
| Tandem Clinical Research - Marrero | Marrero | Louisiana | 70072 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Alliance for Multispecialty Research Kansas City | Kansas City | Missouri | 64114 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Lucas Research | Morehead City | North Carolina | 28557 | — |
| Research Innovations LLC dba Internal Medicine Care Inc | Beavercreek | Ohio | 45431 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| Alliance for Multispecialty Research Norman | Norman | Oklahoma | 73069 | — |
| Medical Care LLC | Elizabethton | Tennessee | 37643 | — |
| PanAmerican Clinical Research LLC | Brownsville | Texas | 78520 | — |
| Headlands Research Brownsville | Brownsville | Texas | 78526 | — |
| Clinical Trials of Texas | San Antonio | Texas | 78229 | — |
| Diabetes and Glandular Disease Clinic | San Antonio | Texas | 78229 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78229 | — |
| Texas Diabetes Institute | San Antonio | Texas | 78284 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 49 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05669599, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 19, 2026 · Synced Sep 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05669599 live on ClinicalTrials.gov.