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Recruiting Phase 2 Interventional

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

ClinicalTrials.gov ID: NCT05673148

Public ClinicalTrials.gov record NCT05673148. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 25, 2026, 2:33 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Pragmatic Randomized Phase II Trial Evaluating Total Ablative Therapy for Patients With Limited Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares the addition of total ablative therapy to the usual systemic therapy versus the usual systemic therapy alone in treating patients with advanced colorectal cancer that has spread to up to 4 body sites (limited metastatic). The usual approach for patients who are not participating in a study is treatment with intravenous (through a vein) and/or oral medications (systemic therapy) to help stop the cancer sites from getting larger and the spread of the cancer to additional body sites. The ablative local therapy will consist of any combination of very focused, intensive radiotherapy called stereotactic ablative radiotherapy (SABR), surgical resection, or microwave ablation, which is a procedure where a needle is temporarily inserted in the tumor and heat is used to destroy the cancer cells. The addition of ablative local therapy to the usual approach of systemic therapy could be more effective than usual chemotherapy alone by increasing the life of patients with limited metastatic colorectal cancer.

Study identification

NCT ID
NCT05673148
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
146 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 8, 2023
Primary completion
Jul 2, 2028
Completion
Aug 11, 2032
Last update posted
Sep 2, 2026

2023 – 2032

United States locations

U.S. sites
186
U.S. states
39
U.S. cities
149
Facility City State ZIP Site status
Kingman Regional Medical Center Kingman Arizona 86401 Recruiting
Mayo Clinic Hospital in Arizona Phoenix Arizona 85054 Recruiting
Tower Cancer Research Foundation Beverly Hills California 90211 Recruiting
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Irvine California 92612 Recruiting
Cedars-Sinai Medical Center Los Angeles California 90048 Recruiting
UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California 92868 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Active, not recruiting
Beebe Medical Center Lewes Delaware 19958 Recruiting
Beebe South Coastal Health Campus Millville Delaware 19967 Recruiting
Helen F Graham Cancer Center Newark Delaware 19713 Recruiting
Medical Oncology Hematology Consultants PA Newark Delaware 19713 Recruiting
Christiana Care Health System-Christiana Hospital Newark Delaware 19718 Recruiting
Beebe Health Campus Rehoboth Beach Delaware 19971 Recruiting
Christiana Care Health System-Wilmington Hospital Wilmington Delaware 19801 Recruiting
Sibley Memorial Hospital Washington D.C. District of Columbia 20016 Active, not recruiting
George Washington University Medical Center Washington D.C. District of Columbia 20037 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs Florida 33065 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 Recruiting
UM Sylvester Comprehensive Cancer Center at Hollywood Hollywood Florida 33021 Recruiting
Jupiter Medical Center Jupiter Florida 33458 Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
Miami Cancer Institute Miami Florida 33176 Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Grady Health System Atlanta Georgia 30303 Recruiting
Emory Proton Therapy Center Atlanta Georgia 30308 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Emory Saint Joseph's Hospital Atlanta Georgia 30342 Recruiting
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 Recruiting
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 Recruiting
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 Recruiting
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 Recruiting
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 Recruiting
University of Illinois Chicago Illinois 60612 Recruiting
Baptist Health Floyd New Albany Indiana 47150 Recruiting
UI Health Care Mission Cancer and Blood - Ankeny Clinic Ankeny Iowa 50023 Recruiting
University of Iowa Healthcare Cancer Services Quad Cities Bettendorf Iowa 52722 Recruiting
Mercy Cancer Center-West Lakes Clive Iowa 50325 Recruiting
UI Health Care Mission Cancer and Blood - West Des Moines Clinic Clive Iowa 50325 Recruiting
Greater Regional Medical Center Creston Iowa 50801 Recruiting
Iowa Methodist Medical Center Des Moines Iowa 50309 Recruiting
UI Health Care Mission Cancer and Blood - Des Moines Clinic Des Moines Iowa 50309 Recruiting
Mercy Medical Center - Des Moines Des Moines Iowa 50314 Recruiting
UI Health Care Mission Cancer and Blood - Laurel Clinic Des Moines Iowa 50314 Recruiting
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 Recruiting
UI Health Care Mission Cancer and Blood - Waukee Clinic Waukee Iowa 50263 Recruiting
Mercy Medical Center-West Lakes West Des Moines Iowa 50266 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Active, not recruiting
Baptist Health Louisville Louisville Kentucky 40207 Recruiting
University Medical Center New Orleans New Orleans Louisiana 70112 Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore Maryland 21287 Active, not recruiting
Boston Medical Center Boston Massachusetts 02118 Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor Ann Arbor Michigan 48106 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan 48114 Recruiting
Trinity Health Medical Center - Brighton Brighton Michigan 48114 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan 48188 Recruiting
Trinity Health Medical Center - Canton Canton Michigan 48188 Recruiting
Chelsea Hospital Chelsea Michigan 48118 Recruiting
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan 48118 Recruiting
Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan 48038 Active, not recruiting
Corewell Health Dearborn Hospital Dearborn Michigan 48124 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Corewell Health Farmington Hills Hospital Farmington Hills Michigan 48336 Recruiting
Genesys Hurley Cancer Institute Flint Michigan 48503 Recruiting
Hurley Medical Center Flint Michigan 48503 Recruiting
Allegiance Health Jackson Michigan 49201 Active, not recruiting
University of Michigan Health - Sparrow Lansing Lansing Michigan 48912 Recruiting
Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan 48154 Recruiting
Henry Ford Health Providence Novi Hospital Novi Michigan 48374 Active, not recruiting
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073 Recruiting
Henry Ford Health Providence Southfield Hospital Southfield Michigan 48075 Active, not recruiting
Corewell Health Beaumont Troy Hospital Troy Michigan 48085 Recruiting
Henry Ford West Bloomfield Hospital West Bloomfield Michigan 48322 Active, not recruiting
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan 48197 Recruiting
Sanford Joe Lueken Cancer Center Bemidji Minnesota 56601 Recruiting
Regions Hospital Saint Paul Minnesota 55101 Recruiting
Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi 39705 Recruiting
Baptist Cancer Center-Grenada Grenada Mississippi 38901 Recruiting
Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi 38652 Recruiting
Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi 38655 Recruiting
Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi 38671 Recruiting
MU Health - University Hospital/Ellis Fischel Cancer Center Columbia Missouri 65212 Recruiting
Parkland Health Center - Farmington Farmington Missouri 63640 Recruiting
Heartland Regional Medical Center Saint Joseph Missouri 64506 Recruiting
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 Recruiting
Mercy Hospital Springfield Springfield Missouri 65804 Recruiting
Mercy Hospital South St Louis Missouri 63128 Recruiting
Missouri Baptist Medical Center St Louis Missouri 63131 Recruiting
Mercy Hospital Saint Louis St Louis Missouri 63141 Recruiting
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 Recruiting
Billings Clinic Cancer Center Billings Montana 59101 Recruiting
Benefis Sletten Cancer Institute Great Falls Montana 59405 Recruiting
Nebraska Medicine-Bellevue Bellevue Nebraska 68123 Recruiting
Nebraska Medicine-Village Pointe Omaha Nebraska 68118 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center Lebanon New Hampshire 03756 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Englewood Hospital and Medical Center Englewood New Jersey 07631 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Jersey Shore Medical Center Neptune City New Jersey 07753 Recruiting
University of New Mexico Cancer Center Albuquerque New Mexico 87106 Recruiting
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
The New York Hospital Medical Center of Queens Flushing New York 11355 Recruiting
Northwell Health Physicians Partners Radiation Medicine at Queens Forest Hills New York 11375 Recruiting
Northwell Health Cancer Institute at Huntington Greenlawn New York 11740 Recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 Recruiting
Northern Westchester Hospital Mount Kisco New York 10549 Recruiting
Mount Sinai West New York New York 10019 Recruiting
Mount Sinai Hospital New York New York 10029 Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York 10032 Active, not recruiting
Manhattan Eye Ear and Throat Hospital New York New York 10065 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
NYP/Weill Cornell Medical Center New York New York 10065 Recruiting
Lenox Hill Hospital New York New York 10075 Recruiting
Queens Cancer Center Rego Park New York 11374 Recruiting
University of Rochester Rochester New York 14642 Active, not recruiting
Phelps Memorial Hospital Center Sleepy Hollow New York 10591 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Westchester Medical Center Valhalla New York 10595 Recruiting
Wilmot Cancer Institute at Webster Webster New York 14580 Active, not recruiting
Carolinas Medical Center/Levine Cancer Institute Charlotte North Carolina 28203 Recruiting
Atrium Health Cabarrus/LCI-Concord Concord North Carolina 28025 Recruiting
East Carolina University Greenville North Carolina 27834 Recruiting
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 Recruiting
Sanford Bismarck Medical Center Bismarck North Dakota 58501 Recruiting
Sanford Broadway Medical Center Fargo North Dakota 58122 Recruiting
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 Recruiting
Dayton Physicians LLC-Miami Valley South Centerville Ohio 45459 Active, not recruiting
Miami Valley Hospital South Centerville Ohio 45459 Recruiting
MetroHealth Medical Center Cleveland Ohio 44109 Active, not recruiting
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 Recruiting
Miami Valley Hospital Dayton Ohio 45409 Recruiting
Premier Blood and Cancer Center Dayton Ohio 45409 Recruiting
Dayton Physician LLC - Englewood Dayton Ohio 45415 Active, not recruiting
Miami Valley Hospital North Dayton Ohio 45415 Recruiting
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 Recruiting
Dayton Physicians LLC-Atrium Franklin Ohio 45005 Active, not recruiting
Miami Valley Cancer Care and Infusion Greenville Ohio 45331 Recruiting
Upper Valley Medical Center Troy Ohio 45373 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Active, not recruiting
Saint Charles Health System Bend Oregon 97701 Recruiting
Oregon Health and Science University Portland Oregon 97239 Recruiting
Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania 19317 Recruiting
Geisinger Medical Center Danville Pennsylvania 17822 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 Recruiting
Lancaster General Ann B Barshinger Cancer Institute Lancaster Pennsylvania 17601 Active, not recruiting
Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania 17837 Recruiting
Allegheny General Hospital Pittsburgh Pennsylvania 15212 Recruiting
West Penn Hospital Pittsburgh Pennsylvania 15224 Recruiting
Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania 18711 Recruiting
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 Recruiting
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 Recruiting
Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee 38120 Recruiting
Vanderbilt University/Ingram Cancer Center Nashville Tennessee 37232 Recruiting
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Withdrawn
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Bon Secours Memorial Regional Medical Center Mechanicsville Virginia 23116 Recruiting
Bon Secours Saint Francis Medical Center Midlothian Virginia 23114 Recruiting
Bon Secours Saint Mary's Hospital Richmond Virginia 23226 Recruiting
Bon Secours Cancer Institute at Reynolds Crossing Richmond Virginia 23230 Recruiting
Valley Medical Center Renton Washington 98055 Recruiting
Edwards Comprehensive Cancer Center Huntington West Virginia 25701 Recruiting
Aspirus Cancer Care-Antigo-Volm Cancer Center Antigo Wisconsin 54409 Recruiting
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton Appleton Wisconsin 54915 Recruiting
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield Brookfield Wisconsin 53045 Recruiting
Ascension Calumet Hospital-Chilton Chilton Wisconsin 53014 Recruiting
Ascension Southeast Wisconsin Hospital - Franklin Franklin Wisconsin 53132 Recruiting
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon Mequon Wisconsin 53097 Recruiting
Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee Milwaukee Wisconsin 53210 Recruiting
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus Milwaukee Wisconsin 53211 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Ascension Northeast Wisconsin-Mercy Hospital-Oshkosh Oshkosh Wisconsin 54904 Recruiting
Ascension All Saints Hospital-Spring Street-Racine Racine Wisconsin 53405 Recruiting
Aspirus Cancer Care-Rhinelander-James Beck Cancer Center Rhinelander Wisconsin 54501 Recruiting
Aspirus Cancer Care - Stevens Point Stevens Point Wisconsin 54481 Recruiting
Aspirus Cancer Care-Wausau Wausau Wisconsin 54401 Recruiting
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa Wauwatosa Wisconsin 53226 Recruiting
Aspirus Cancer Care - Wisconsin Rapids Wisconsin Rapids Wisconsin 54494 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05673148, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 2, 2026 · Synced Sep 25, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05673148 live on ClinicalTrials.gov.

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