A Study of Milvexian in Participants After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack- LIBREXIA-STROKE

ClinicalTrials.gov ID: NCT05702034

Public ClinicalTrials.gov record NCT05702034. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Apr 23, 2026, 6:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention After an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack

Study identification

NCT ID: NCT05702034
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Janssen Research & Development, LLC; Industry
Enrollment: 15,000 participants

Conditions and interventions

Conditions

Ischemic Stroke; Ischemic Attack, Transient

Interventions

Milvexian Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 40 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 14, 2023
Primary completion: Nov 10, 2026
Completion: Dec 8, 2026
Last update posted: Apr 12, 2026

2023 – 2026

United States locations

U.S. sites: 127
U.S. states: 33
U.S. cities: 105

Facility	City	State	ZIP	Site status
Banner Desert Medical Center	Mesa	Arizona	85202	Recruiting
University of Arizona	Tucson	Arizona	85721	Recruiting
Plaza Neuroscience Clinic	Fayetteville	Arkansas	72703-3902	Recruiting
Alta Bates Medical Center Cancer Center	Berkeley	California	94705	Recruiting
Providence Saint Joseph Medical Center - Cancer Center	Burbank	California	91505	Recruiting
Mills Peninsula Health Services	Burlingame	California	94010	Recruiting
Sutter Health - Eden Medical Center	Castro Valley	California	94546	Recruiting
Neurology Center of North Orange County	Fullerton	California	92835	Recruiting
Glendale Adventist Medical Center	Glendale	California	91206	Recruiting
UC Irvine Healthcare Center	Irvine	California	92697	Recruiting
Sharp Grossmont Hospital	La Mesa	California	91942	Recruiting
Long Beach Memorial	Long Beach	California	90806	Recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Recruiting
Mission Hospital Regional Medical Center	Mission Viejo	California	92691	Recruiting
Hoag Memorial Hospital	Newport Beach	California	92663	Recruiting
Stanford Stroke Center	Palo Alto	California	94304-1419	Recruiting
Kaiser Permanente 1	Redwood City	California	94063	Recruiting
University of California Davis Health System	Sacramento	California	95817	Recruiting
Kaiser Permanente	Sacramento	California	95825-2115	Recruiting
California Pacific Medical Center	San Francisco	California	94115	Recruiting
Pacific Neuroscience Institute	Santa Monica	California	90404	Recruiting
Harbor Ucla Medical Center	Torrance	California	90502	Completed
Providence Little Company of Mary	Torrance	California	90503	Recruiting
PIH Health Hospital	Whittier	California	90602	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Nuvance Health Medical Practices Cardiology Danbury	Danbury	Connecticut	06810	Recruiting
MedStar Georgetown University Hospital	Washington D.C.	District of Columbia	20007	Recruiting
MedStar Health Research Institute	Washington D.C.	District of Columbia	20010	Recruiting
Boca Raton Regional Hospital	Boca Raton	Florida	33486	Recruiting
Nova Clinical Research, LLC 1	Bradenton	Florida	34209	Recruiting
Nova Clinical Research, LLC	Bradenton	Florida	34209	Recruiting
Morton Plant Hospital	Clearwater	Florida	33756-3394	Recruiting
Baptist Health 1	Miami	Florida	33173	Completed
Advent Health Orlando	Orlando	Florida	32804-5521	Completed
Sacred Heart Hospital	Pensacola	Florida	32504	Completed
Sarasota Memorial Hospital	Sarasota	Florida	34239	Recruiting
Theia Clincial Research, LLC	Temple Terrace	Florida	33617	Recruiting
Saint Marys Medical Center	West Palm Beach	Florida	33407	Recruiting
Augusta University	Augusta	Georgia	30912	Recruiting
Saint Alphonsus Regional Medical Center- Cancer Care Center	Boise	Idaho	83706	Recruiting
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
Insight Hospital and Medical Center Chicago	Chicago	Illinois	60616	Recruiting
Northshore University Healthsystem	Evanston	Illinois	60201	Recruiting
St. Joseph's Regional Medical Center	Joliet	Illinois	60435	Completed
OSF Saint Francis Medical Center	Peoria	Illinois	61637	Recruiting
Blessing Hospital	Quincy	Illinois	62301	Recruiting
Javon Bea Hospital	Rockford	Illinois	61114	Recruiting
Prairie Education And Research Cooperative	Springfield	Illinois	62769	Recruiting
Parkview Research Center	Fort Wayne	Indiana	46845	Completed
IU Health Methodist Hospital	Indianapolis	Indiana	46202	Recruiting
Community Hospital Cardiovascular Research	Munster	Indiana	46321	Suspended
University of Kansas Medical Center Research Institute	Kansas City	Kansas	66160	Recruiting
Ascension via Christi Research	Wichita	Kansas	67214	Recruiting
University of Kentucky Medical Center	Lexington	Kentucky	40506	Recruiting
University of Louisville	Louisville	Kentucky	40202	Recruiting
Pikeville Medical Center	Pikeville	Kentucky	41537	Recruiting
Sinai Hospital of Baltimore	Baltimore	Maryland	21215	Recruiting
Shady Grove Office	Rockville	Maryland	20850	Recruiting
Comprehensive Neurology Services	Silver Spring	Maryland	20902	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02216	Recruiting
Detroit Medical Center	Detroit	Michigan	48201	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
St John Hospital and Medical Center	Detroit	Michigan	48236	Completed
Michigan State University	East Lansing	Michigan	48824	Recruiting
Detroit Clinical Research Center	Farmington Hills	Michigan	48334	Completed
Memorial Institute for Neurosciences and Multiple Sclerosis	Owosso	Michigan	48867	Completed
William Beaumont Hospital 1	Royal Oak	Michigan	48073	Completed
William Beaumont Hospital	Royal Oak	Michigan	48073	Recruiting
Providence & Providence Park Hospital	Southfield	Michigan	48075	Completed
M Health Fairview Ridges Hospital	Burnsville	Minnesota	55337	Recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Recruiting
University Of Minnesota Medical Center	Saint Louis Park	Minnesota	55416	Recruiting
Cardiology Associates of North Mississippi	Tupelo	Mississippi	38801	Completed
SSM Health DePaul Hospital	Bridgeton	Missouri	63044	Recruiting
Cox Health	Springfield	Missouri	65807	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68106	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601-1915	Recruiting
Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Rutgers New Jersey Medical School	Newark	New Jersey	07103	Completed
Capital Health Regional Medical Center	Trenton	New Jersey	08638	Recruiting
Mercy Hospital	Buffalo	New York	14220	Recruiting
Jamaica Hospital Medical Center	Jamaica	New York	11418	Recruiting
United Health Services	Johnson City	New York	13790	Completed
Lenox Hill Hospital	Lake Success	New York	11041	Recruiting
Long Island Jewish Med Ctr	New Hyde Park	New York	11040	Completed
Weill Cornell Medical College	New York	New York	10021	Recruiting
Lincoln Hospital	The Bronx	New York	10451	Recruiting
Mission Hospital	Asheville	North Carolina	28801	Recruiting
Novant Health	Charlotte	North Carolina	28204	Completed
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Guilford Neurologic Associates	Greensboro	North Carolina	27405	Recruiting
Summa Health System	Akron	Ohio	44304	Recruiting
TriHealth Network	Cincinnati	Ohio	45220	Recruiting
University of Cincinnati	Cincinnati	Ohio	45267	Recruiting
The Ohio State University	Columbus	Ohio	43210	Recruiting
Hightower Clinical	Oklahoma City	Oklahoma	73102	Recruiting
Ascension Medical Group - St. John Clinic Infectious Disease	Tulsa	Oklahoma	74104	Recruiting
Providence Portland Medical Center	Portland	Oregon	97213	Recruiting
Providence St Vincent Medical Center	Portland	Oregon	97225	Recruiting
Oregon Health And Science University	Portland	Oregon	97239	Recruiting
Abington Memorial Hospital	Abington	Pennsylvania	19001	Recruiting
UPMC Hamot	Erie	Pennsylvania	16550	Recruiting
University of Pennsylvania Health System	Philadelphia	Pennsylvania	19104	Recruiting
Thomas Jefferson University	Philadelphia	Pennsylvania	19107	Recruiting
Temple University Hospital Jeanes Campus	Philadelphia	Pennsylvania	19111	Recruiting
Temple University Hospital	Philadelphia	Pennsylvania	19140	Recruiting
Einstein Medical Center	Philadelphia	Pennsylvania	19141	Recruiting
Rhode Island Hospital Warren Alpert Medical School Brown University	Providence	Rhode Island	02905	Recruiting
Centennial Medical Center	Nashville	Tennessee	37203	Recruiting
TriStar Skyline Medical Center	Nashville	Tennessee	37207	Recruiting
Saint Thomas Health	Nashville	Tennessee	37215	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Seton Medical Center	Austin	Texas	78701	Recruiting
Baylor Research Institute	Dallas	Texas	75204	Recruiting
Neurology Consultants of Dallas, PA	Dallas	Texas	75231	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
Houston Methodist Neurological Institute	Houston	Texas	77030	Recruiting
McGovern Medical School UT Physicians Neurosurgery Texas Medical Center	Houston	Texas	77030	Recruiting
Houston Methodist Willowbrook Hospital	Houston	Texas	77070	Recruiting
Emergency Medicine Covenant Medical Center	Lubbock	Texas	79410	Recruiting
Sentara Medical Group	Norfolk	Virginia	23502	Recruiting
Winchester Medical Center	Winchester	Virginia	22601	Recruiting
Providence Regional Medical Center Everett	Everett	Washington	98201	Completed
Multiple Sclerosis Center at Evergreen	Kirkland	Washington	98034	Recruiting
Sacred Heart Medical Center	Spokane	Washington	99204	Recruiting
Mayo Clinic Health System	Eau Claire	Wisconsin	54703	Recruiting
Mayo Clinic Health System 1	La Crosse	Wisconsin	54601	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 753 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05702034, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 12, 2026 · Synced Apr 23, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05702034 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →