Testing Radiation and HER2-targeted Therapy Versus HER2-targeted Therapy Alone for Low-risk HER2-positive Breast Cancer
Public ClinicalTrials.gov record NCT05705401. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO)
Study identification
- NCT ID
- NCT05705401
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- NRG Oncology
- Other
- Enrollment
- 1,300 participants
Conditions and interventions
Conditions
Not listed
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 18, 2023
- Primary completion
- Jan 31, 2034
- Completion
- Jan 31, 2037
- Last update posted
- Apr 26, 2026
2023 – 2037
United States locations
- U.S. sites
- 33
- U.S. states
- 3
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cancer Center at Saint Joseph's | Phoenix | Arizona | 85004 | — |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | — |
| Kaiser Permanente-Deer Valley Medical Center | Antioch | California | 94531 | — |
| Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California | 93420 | — |
| PCR Oncology | Arroyo Grande | California | 93420 | — |
| Sutter Auburn Faith Hospital | Auburn | California | 95602 | — |
| Sutter Cancer Centers Radiation Oncology Services-Auburn | Auburn | California | 95603 | — |
| Tower Cancer Research Foundation | Beverly Hills | California | 90211 | — |
| Sutter Cancer Centers Radiation Oncology Services-Cameron Park | Cameron Park | California | 95682 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Kaiser Permanente Dublin | Dublin | California | 94568 | — |
| Kaiser Permanente-Fremont | Fremont | California | 94538 | — |
| Palo Alto Medical Foundation-Fremont | Fremont | California | 94538 | — |
| Fresno Cancer Center | Fresno | California | 93720 | — |
| Kaiser Permanente-Fresno | Fresno | California | 93720 | — |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | — |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | — |
| City of Hope Antelope Valley | Lancaster | California | 93534 | — |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| Memorial Medical Center | Modesto | California | 95355 | — |
| Kaiser Permanente-Modesto | Modesto | California | 95356 | — |
| Palo Alto Medical Foundation-Camino Division | Mountain View | California | 94040 | — |
| Kaiser Permanente Oakland-Broadway | Oakland | California | 94611 | — |
| Kaiser Permanente-Oakland | Oakland | California | 94611 | — |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Palo Alto Medical Foundation Health Care | Palo Alto | California | 94301 | — |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | — |
| Pomona Valley Hospital Medical Center | Pomona | California | 91767 | — |
| Kaiser Permanente-Rancho Cordova Cancer Center | Rancho Cordova | California | 95670 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05705401, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2026 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05705401 live on ClinicalTrials.gov.