Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

ClinicalTrials.gov ID: NCT05734066

Public ClinicalTrials.gov record NCT05734066. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Jul 21, 2026, 10:05 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Recommended Phase 2 Dose (RP2D), and Efficacy of Lurbinectedin Monotherapy in Pediatric Participants With Previously Treated Solid Tumors Followed by Expansion to Assess Efficacy and Safety in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma.

Study identification

NCT ID: NCT05734066
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Jazz Pharmaceuticals; Industry
Enrollment: 60 participants

Conditions and interventions

Conditions

Interventions

Lurbinectedin Drug

Drug

Eligibility (public fields only)

Age range: 2 Years to 30 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 22, 2023
Primary completion: Jan 27, 2028
Completion: Apr 19, 2028
Last update posted: Feb 2, 2026

2023 – 2028

United States locations

U.S. sites: 14
U.S. states: 11
U.S. cities: 14

Facility	City	State	ZIP	Site status
Children's Hospital of Los Angeles	Los Angeles	California	90027	Recruiting
Lucile Packard Children's Hospital	Palo Alto	California	94304	Recruiting
Children's National Hospital	Washington D.C.	District of Columbia	20010	Recruiting
Johns Hopkins All Children's Hospital	St. Petersburg	Florida	33701	Recruiting
Children's Healthcare of Atlanta at Arthur M. Blank Hospital	Atlanta	Georgia	30329	Recruiting
Johns Hopkins University	Baltimore	Maryland	21238	Recruiting
Corewell Health	Grand Rapids	Michigan	49503	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
St. Jude Children's Research Hospital	Memphis	Tennessee	38105	Recruiting
Children's Health Dallas	Dallas	Texas	75235	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05734066, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Feb 2, 2026 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05734066 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →