A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
Public ClinicalTrials.gov record NCT05738486. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Investigating the Effect of Different Donanemab Dosing Regimens on ARIA-E and Amyloid Lowering in Adults With Early Symptomatic Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptomatic Alzheimer's disease (AD) and explore participant characteristics that might predict risk of ARIA. Approximately 375 additional participants will be enrolled in addendum 2. Addendum 3 includes a subset of participants from the main study to receive a single dose. The study will last approximately 91 weeks and include up to 26 visits in the main study.
Study identification
- NCT ID
- NCT05738486
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,175 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 28, 2023 (Actual)
- Primary completion
- May 16, 2024 (Actual)
- Completion
- May 2027 (Estimated)
- Last update posted
- Jun 18, 2026
2023 – 2027
United States locations
- U.S. sites
- 43
- U.S. states
- 12
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| MD First Research - Chandler | Chandler | Arizona | 85286 | — |
| Irvine Clinical Research | Irvine | California | 92614 | — |
| Healthy Brain Clinic | Long Beach | California | 90804 | — |
| California Neuroscience Research Medical Group, Inc. | Sherman Oaks | California | 91403 | — |
| JEM Research Institute | Atlantis | Florida | 33462 | — |
| VIN-Julie Schwartzbard | Aventura | Florida | 33180 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| K2 Medical Research | Clermont | Florida | 34711 | — |
| Brain Matters Research | Delray Beach | Florida | 33445 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Finlay Medical Research | Greenacres City | Florida | 33467 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33024 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| ClinCloud - Maitland | Maitland | Florida | 32751 | — |
| K2 Medical Research | Maitland | Florida | 32751 | — |
| ClinCloud - Viera | Melbourne | Florida | 32940 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Charter Research - Winter Park | Orlando | Florida | 32803 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Alzheimer's Research and Treatment Center | Stuart | Florida | 34997 | — |
| K2 Medical Research - Tampa | Tampa | Florida | 33607 | — |
| K2 Summit Research | The Villages | Florida | 32159 | — |
| Charter Research - Lady Lake | The Villages | Florida | 32162 | — |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | — |
| Palm Beach Neurology | West Palm Beach | Florida | 33407 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Columbus Memory Center, LLC | Columbus | Georgia | 31909 | — |
| CenExel iResearch, LLC | Decatur | Georgia | 30030 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| Adams Clinical | Watertown | Massachusetts | 02472 | — |
| QUEST Research Institute | Farmington Hills | Michigan | 48334 | — |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | — |
| Gadolin Research | Beaumont | Texas | 77702 | — |
| Kerwin Medical Center | Dallas | Texas | 75231 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77054 | — |
| Re:Cognition Health | Fairfax | Virginia | 22031 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
| Universal Research Group | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05738486, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 18, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05738486 live on ClinicalTrials.gov.