ClinicalTrials.gov record
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.
ClinicalTrials.gov ID: NCT05739383
Public ClinicalTrials.gov record NCT05739383. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-controlled Multicenter Study to Evaluate the Effect of Inclisiran on Preventing Major Adverse Cardiovascular Events in High-risk Primary Prevention Patients (VICTORION-1 PREVENT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
CKJX839D12302 is a pivotal Phase III study designed to test the hypothesis that treatment with inclisiran sodium 300 milligram (mg) subcutaneous (s.c.) administered on Day 1, Day 90, and every 6 months thereafter in patients at high cardiovascular (CV) risk without a prior major atherosclerotic cardiovascular disease (ASCVD) event will significantly reduce the risk of 4-Point-Major Adverse Cardiovascular Events (4P-MACE) defined as a composite of CV death, non-fatal myocardial infarction (MI), non-fatal ischemic stroke, and urgent coronary revascularization, compared to placebo.
Study identification
- NCT ID
- NCT05739383
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 14,012 participants
Conditions and interventions
Interventions
Drug
Eligibility (public fields only)
- Age range
- 40 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 9, 2023 (Actual)
- Primary completion
- Apr 16, 2029 (Estimated)
- Completion
- Apr 16, 2029 (Estimated)
- Last update posted
- Sep 4, 2026
2023 – 2029
United States locations
- U.S. sites
- 242
- U.S. states
- 42
- U.S. cities
- 191
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Alabama Research | Birmingham | Alabama | 35209 | — |
| UAB St Vincents | Birmingham | Alabama | 35211 | — |
| Eastern Shore Research Institute | Fairhope | Alabama | 36532 | — |
| G and L Research LLC | Foley | Alabama | 36535 | — |
| Longwood Research | Huntsville | Alabama | 35801 | — |
| CB Flock Corporation | Mobile | Alabama | 36608 | — |
| The Center for Clinical Trials | Saraland | Alabama | 36571 | — |
| Synexus | Glendale | Arizona | 85306 | — |
| Lenzmeier Family Practice | Glendale | Arizona | 85308 | — |
| Clinical Research Inst of Arizona | Sun City West | Arizona | 85375 | — |
| Clinical Research Advantage Fiel Family and Sports Med, PC | Tempe | Arizona | 85283 | — |
| Synexus Clinical Research US Inc | Tucson | Arizona | 85741 | — |
| Cardiovascular Res Found | Beverly Hills | California | 90210 | — |
| National Heart Institute | Beverly Hills | California | 90211 | — |
| Alliance Clinical | Canoga Park | California | 91303 | — |
| Inland Psychiatric Medical Group | Chino | California | 91710 | — |
| Valley Clinical Trials Inc | Covina | California | 91723 | — |
| Keck Medical Center USC | Los Angeles | California | 90033 | — |
| Charles R Drew University of Medicine and Science | Los Angeles | California | 90059 | — |
| C for Endo Diabetes and MD | Newhall | California | 91321 | — |
| California Medical Research Associates Inc | Northridge | California | 91324 | — |
| Valley Clinical Trials | Northridge | California | 91325 | — |
| Stanford University Medical Center | Palo Alto | California | 94304 | — |
| Clinical Trials Research Sacramento | Sacramento | California | 95821-2134 | — |
| Cordova Clinical Research | Sacramento | California | 95841 | — |
| University of California San Diego | San Diego | California | 92103 | — |
| Kaiser Permanente San Diego | San Diego | California | 92108 | — |
| Acclaim Clinical Research | San Diego | California | 92120 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| Harbor UCLA Medical Center | Torrance | California | 90502 | — |
| Cardiology Associates Medical Group | Ventura | California | 93003 | — |
| Blue Coast Research Center LLC | Vista | California | 92081 | — |
| Interv Cardiology Med Grp | West Hills | California | 91307 | — |
| South Denver Cardiology Associates PC | Littleton | Colorado | 80120 | — |
| Cardiology Ass of Fairfield County | Stamford | Connecticut | 06905 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| Excel Medical Clinical Trials LLC | Boca Raton | Florida | 33434 | — |
| Nova Clinical Research LLC | Bradenton | Florida | 34209 | — |
| Bay Care Medical Group | Clearwater | Florida | 33756 | — |
| Clearwater Cardiovascular and Interventional Consultants | Clearwater | Florida | 33756 | — |
| Tampa Bay Medical Research | Clearwater | Florida | 33761 | — |
| Cardiology Research Associates | Daytona Beach | Florida | 32117 | — |
| Hillcrest Medical Research | DeLand | Florida | 32720 | — |
| Personal Physicians Care | Delray Beach | Florida | 33445 | — |
| Fleming Island Ctr Clinical Res. | Fleming Island | Florida | 32003 | — |
| Proactive Clinical Research | Fort Lauderdale | Florida | 33308 | — |
| Qway Research | Hialeah | Florida | 33010 | — |
| Sister Life Research Inc | Hialeah | Florida | 33013 | — |
| Center for Diabetes and Endocrine Care | Hollywood | Florida | 33021 | — |
| South Florida Rsrch Solutions LLC | Hollywood | Florida | 33021 | — |
| Zenith Clinical Research | Hollywood | Florida | 33021 | — |
| Encore Medical Research | Hollywood | Florida | 33024 | — |
| UF Health Science Center | Jacksonville | Florida | 32209 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| Columbus Clinical Services LLC | Miami | Florida | 33125 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| Infinite Clinical Research | Miami | Florida | 33133 | — |
| Springs Medical And Research | Miami | Florida | 33135 | — |
| L and C Professional Medical Institute | Miami | Florida | 33144 | — |
| Regenerate Clinical Trial | Miami | Florida | 33155 | — |
| International Research Associates LLC | Miami | Florida | 33156 | — |
| A&A Research Group Inc | Miami | Florida | 33186 | — |
| Meridian International Research | Miami Gardens | Florida | 33014 | — |
| Inpatient Research Clinical LLC | Miami Lakes | Florida | 33014 | — |
| RM Medical Research Inc | Miami Lakes | Florida | 33014 | — |
| Indago Research and Health Ctr Inc | Miami Lakes | Florida | 33016 | — |
| FXM Clin Res Miramar LLC | Miramar | Florida | 33027 | — |
| Advent Health Orlando | Orlando | Florida | 32803 | — |
| CTMD Research | Palm Springs | Florida | 33406 | — |
| DBC Research USA | Pembroke Pines | Florida | 33029 | — |
| Fam Medical Specialists Of Fl Plc | Plant City | Florida | 33563 | — |
| St Johns Center | Ponte Vedra | Florida | 32801 | — |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | — |
| East Coast Inst for Research LLC | Saint Augustine | Florida | 32086 | — |
| Cardiovascular Center Of Sarasota | Sarasota | Florida | 34239 | — |
| Advanced Medical Research Center | St. Petersburg | Florida | 33713 | — |
| James A Haley Veterans Hospital | Tampa | Florida | 33612 | — |
| BayCare Health System | Tampa | Florida | 33705 | — |
| Cardiology Partners Clinical Research Institute | Wellington | Florida | 33449 | — |
| Flourish Research | Winter Park | Florida | 32789 | — |
| East Coast Research | Canton | Georgia | 30114 | — |
| Javara Research | Fayetteville | Georgia | 30214 | — |
| The Jones Center For Diabetes And Endocrine Wellness | Macon | Georgia | 31210 | — |
| Atlanta Heart Specialists LLC | Tucker | Georgia | 30084 | — |
| East West Research Institute | Honolulu | Hawaii | 96814 | — |
| Kootenai Heart Clinic-Sandpoint | Sandpoint | Idaho | 83864 | — |
| Endeavor Health Clinical Op- NCH | Arlington Heights | Illinois | 60005 | — |
| Chicago Clinical Research Inst | Chicago | Illinois | 60607 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Cardiovascular Services | Peoria | Illinois | 61602 | — |
| Beacon Health System | Elkhart | Indiana | 46514 | — |
| Buynak Clinical Research PC | Valparaiso | Indiana | 46383 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Hutchinson Clinic | Hutchinson | Kansas | 67502 | — |
| Cotton O Neil Clinical Res Center | Topeka | Kansas | 66606 | — |
| Kansas Nephrology Research Institute LLC | Wichita | Kansas | 67214 | — |
| Graves Gilbert Clinic | Bowling Green | Kentucky | 42101 | — |
| The Research Group | Lexington | Kentucky | 40503 | — |
| Research Integrity LLC | Owensboro | Kentucky | 42303 | — |
| Cardiovascular Associates Research | Covington | Louisiana | 70433 | — |
| Louisiana Heart Center Research | Covington | Louisiana | 70433 | — |
| Avant Research Associates LLC | Crowley | Louisiana | 70526 | — |
| North Shore Heart and Vascular | Mandeville | Louisiana | 70448 | — |
| Bethesda Medical Clinic | Marrero | Louisiana | 70072 | — |
| NOLA Care Clinical Research | Metairie | Louisiana | 70006 | — |
| Omega Clinical Research | Metairie | Louisiana | 70006 | — |
| CV Ins of the South | Opelousas | Louisiana | 70570 | — |
| Cardiovascular Solutions LLC | Shreveport | Louisiana | 71103 | — |
| Louisiana Heart Center Research | Slidell | Louisiana | 70458 | — |
| Monroe Research Llc | West Monroe | Louisiana | 71291 | — |
| Southern Clinical Research | Zachary | Louisiana | 70791 | — |
| Northeast Cardiology Associates | Bangor | Maine | 04401 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| Metropolitan Cardiovascular Consultants Llc | Beltsville | Maryland | 20705 | — |
| Johns Hopkins University | Columbia | Maryland | 21044 | — |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | — |
| Capitol Cardiology Associates | Lanham | Maryland | 20706 | — |
| MGH | Boston | Massachusetts | 02114-2696 | — |
| Umass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| AA Medical Research Center | Flint | Michigan | 48504 | — |
| MyMichigan Medical Center Midland | Midland | Michigan | 48670 | — |
| Central Michigan University | Saginaw | Michigan | 48601 | — |
| Troy Internal Medicine Research | Troy | Michigan | 48098 | — |
| Trinity Health Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| Essentia Health | Duluth | Minnesota | 55805 | — |
| Abbott Northwestern Hospital | Minneapolis | Minnesota | 55407-3799 | — |
| Synexus Clinical Research US Inc | Richfield | Minnesota | 55432 | — |
| Park Nicollet Institute | Saint Louis Park | Minnesota | 55416 | — |
| Fairview Health Services | Saint Paul | Minnesota | 55103 | — |
| Elite Clinical Research LLC | Jackson | Mississippi | 39202 | — |
| Jackson Heart Clinic | Jackson | Mississippi | 39216 | — |
| VAMC Research-G V Sonny Montgomery Clinic | Jackson | Mississippi | 39216 | — |
| David M Headley Clinic | Port Gibson | Mississippi | 39150 | — |
| Cardiology Associates of North MS | Tupelo | Mississippi | 38801 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| Barnes Jewish Hosp-Washington Univ | St Louis | Missouri | 63110 | — |
| St Louis V A Medical Center | St Louis | Missouri | 63125-4181 | — |
| St Louis Heart and Vascular | St Louis | Missouri | 63136 | — |
| Synexus Clinical Research US Inc | St Louis | Missouri | 63141 | — |
| Mercury Street Medical | Butte | Montana | 59701 | — |
| Nebraska Heart Institute | Lincoln | Nebraska | 68510 | — |
| Lincoln Internal Medicine Associates | Lincoln | Nebraska | 68516 | — |
| CCT Research | Omaha | Nebraska | 68130 | — |
| University of Nebraska Med Center | Omaha | Nebraska | 68198 | — |
| Las Vegas Endocrinology | Henderson | Nevada | 89074 | — |
| AB Clinical Trials | Las Vegas | Nevada | 89119 | — |
| Clinical Research of South Nevada | Las Vegas | Nevada | 89121 | — |
| Advanced Heart Care | Bridgewater | New Jersey | 08807 | — |
| Cardiovas Assoc of Delaware Valley | Elmer | New Jersey | 08318 | — |
| New Jersey Heart | Linden | New Jersey | 07036 | — |
| Albany Medical College | Albany | New York | 12206 | — |
| Capital Cardiology Associates | Albany | New York | 12211 | — |
| New York Presbyterian Queens | Flushing | New York | 11355 | — |
| Mid Hudson Medical Research PLLC | New Windsor | New York | 12553 | — |
| Hudson Valley Urology | Poughkeepsie | New York | 12601 | — |
| Rochester Clinical Research | Rochester | New York | 14609 | — |
| Clinical Research Advantage | The Bronx | New York | 10468 | — |
| Westchester Medical Center | Valhalla | New York | 10595 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| Cary Research Group | Cary | North Carolina | 27511 | — |
| Moses Cone Hospital | Greensboro | North Carolina | 27401 | — |
| Medication Management LLC | Greensboro | North Carolina | 27405 | — |
| IMA Research | Mount Airy | North Carolina | 27030 | — |
| Multispecialty Research Ass Of NC | Raleigh | North Carolina | 27609 | — |
| Accellacare | Statesville | North Carolina | 28625 | — |
| Adv Imaging Prev and Clin Research | Wilmington | North Carolina | 28401 | — |
| Wake Forest University Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58103 | — |
| Altru Health Research Dept. | Grand Forks | North Dakota | 58201 | — |
| Aultman Hospital | Canton | Ohio | 44710 | — |
| Synexus Clinical Research US Inc | Cincinnati | Ohio | 45236 | — |
| Synexus Clinical Research | Columbus | Ohio | 43212 | — |
| Primed Clinical Research | Dayton | Ohio | 45429 | — |
| Providence Medical Group | Dayton | Ohio | 45439 | — |
| NexGen Research | Lima | Ohio | 45801 | — |
| Rama Research LLC | Marion | Ohio | 43302 | — |
| Heart House Research Foundation | Springfield | Ohio | 45504 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| South Oklahoma Heart Research LLC | Oklahoma City | Oklahoma | 73135 | — |
| CCT Hatboro Medical Associates | Horsham | Pennsylvania | 19044 | — |
| Capital Area Research LLC | Newport | Pennsylvania | 17074 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Frontier Clinical Research LLC | Smithfield | Pennsylvania | 15478 | — |
| Care Access | Warwick | Rhode Island | 02886 | — |
| Columbia VA Health Care System | Columbia | South Carolina | 29209 | — |
| Bon Secours Medical Group | Greenville | South Carolina | 29607 | — |
| TRIBE Clinical Research | Greer | South Carolina | 29651 | — |
| Trident Cardiology | Ladson | South Carolina | 29465 | — |
| Main Street Physicians Care | Little River | South Carolina | 29566 | — |
| Care Access Research | Rapid City | South Dakota | 57701 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Wellmont CVA Heart Institute | Greenville | Tennessee | 37745 | — |
| Apex Cardiology Research Associates of Jackson | Jackson | Tennessee | 38301 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| New Phase Research And Development | Knoxville | Tennessee | 37909 | — |
| Accellacare | Knoxville | Tennessee | 37938 | — |
| Cardiovascular Res of Knoxville LLC | Powell | Tennessee | 37849 | — |
| Tennessee Center For Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Pharma Tex Research | Amarillo | Texas | 79106 | — |
| Amarillo Heart Clin Rsh Inst | Amarillo | Texas | 79124 | — |
| North Hills Medical Research Inc | Bedford | Texas | 76021 | — |
| Clinical Research Solution | Cypress | Texas | 77429 | — |
| VA North Texas Health Care System | Dallas | Texas | 75216 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| SW Family Medicine Associates | Dallas | Texas | 75235 | — |
| David Turbay MD PLLC | El Paso | Texas | 79905 | — |
| Texas Health Physicians Group | Fort Worth | Texas | 76107 | — |
| East Texas Cardiology PA | Houston | Texas | 77002 | — |
| Primecare Medical Group | Houston | Texas | 77024 | — |
| Northwest Houston Cardiology PA | Houston | Texas | 77070 | — |
| MedCare Pharma LLC | Houston | Texas | 77079 | — |
| Dallas Heart and Vascular Consultants PA | Houston | Texas | 77084 | — |
| Texas Cardiology Assocs Of Houston | Kingwood | Texas | 77339 | — |
| Epic Clinical Research | Lewisville | Texas | 75057 | — |
| East Texas Research Associates Inc. | Livingston | Texas | 77351 | — |
| Doctors Hospital at Renaissance | McAllen | Texas | 78504 | — |
| Epic Medical Research | Red Oak | Texas | 75154 | — |
| Northeast Clinical Research of San Antonio LLC | San Antonio | Texas | 78233 | — |
| Consano Clinical Research LLC | Shavano Park | Texas | 78231 | — |
| Javara Research | Stephenville | Texas | 76401 | — |
| NRG Wellness Center | Sugarland | Texas | 77478 | — |
| Northwest Houston Clinical Research PLLC | Tomball | Texas | 77375 | — |
| Comprehensive Center | Weslaco | Texas | 78596 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Diabetes And Endocrine Specialists | Sandy City | Utah | 84093 | — |
| Burke Internal Medicine and Research | Burke | Virginia | 22015 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Heart Care Associates P C | Hopewell | Virginia | 23860 | — |
| Carient Heart and Vascular | Manassas | Virginia | 20109 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298-0111 | — |
| Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| Centricity Research Suffolk Fam Med | Suffolk | Virginia | 23435 | — |
| MultiCare Ins Research Innovation | Puyallup | Washington | 98372 | — |
| Universal Research Group LLC | Tacoma | Washington | 98405 | — |
| Confluence Health Hospital | Wenatchee | Washington | 98801 | — |
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | — |
| Midwest Endocrinology Associates | Milwaukee | Wisconsin | 53215 | — |
| Cardiovascular Research and Education Foundation Inc | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 741 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05739383, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 4, 2026 · Synced Oct 20, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05739383 live on ClinicalTrials.gov.