ClinicalTrials.gov record
A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome
ClinicalTrials.gov ID: NCT05754957
Public ClinicalTrials.gov record NCT05754957. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular \[CV\] death, myocardial infarction \[MI\], and ischemic stroke).
Study identification
- NCT ID
- NCT05754957
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 14,194 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 7, 2023 (Actual)
- Primary completion
- Feb 6, 2026 (Actual)
- Completion
- Feb 6, 2026 (Actual)
- Last update posted
- Jul 6, 2026
2023 – 2026
United States locations
- U.S. sites
- 162
- U.S. states
- 37
- U.S. cities
- 144
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC | Alexander City | Alabama | 35010 | — |
| SORRA Research | Birmingham | Alabama | 35203 | — |
| Ascension St. Vincent's Health System | Birmingham | Alabama | 35205 | — |
| IMC-Diagnostic and Medical Clinic | Mobile | Alabama | 36604 | — |
| Cardiology Associates of Mobile Inc | Mobile | Alabama | 36608 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Valleywise Health Medical Center | Phoenix | Arizona | 85008 | — |
| HonorHealth Neurology | Scottsdale | Arizona | 85258 | — |
| Arkansas Heart Hospital | Little Rock | Arkansas | 72211 | — |
| Bakersfield Memorial Hospital | Bakersfield | California | 93306 | — |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | — |
| Radin Cardiovascular Medical Group | Newport Beach | California | 92663 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Stanford University School of Medicine | Palo Alto | California | 94304 | — |
| VA Palo Alto Healthcare System | Palo Alto | California | 94304 | — |
| Huntington Hospital | Pasadena | California | 91105 | — |
| The Cardiovascular Center | Redding | California | 96001 | — |
| University Of California San Diego | San Diego | California | 92103 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| VA San Diego Health Care System | San Diego | California | 92161 | — |
| UCLA | Santa Monica | California | 90401 | — |
| NorthBay Clinical Research, LLC | Santa Rosa | California | 95405 | — |
| Ramin Manshadi, MD | Stockton | California | 95204 | — |
| South Denver Cardiology Associates PC | Littleton | Colorado | 80120 | — |
| Nuvance Health Medical Practices Cardiology Danbury | Danbury | Connecticut | 06810 | — |
| Cardiology Associates of Fairfield County, P.C. | Stamford | Connecticut | 06905 | — |
| George Washington University Medical Center | Washington D.C. | District of Columbia | 20037 | — |
| FWD Clinical Research | Boca Raton | Florida | 33434 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Holy Cross Hospital Inc. | Fort Lauderdale | Florida | 33308 | — |
| Integrative Research Associates | Fort Lauderdale | Florida | 33312 | — |
| University of Florida Health Jacksonville | Gainesville | Florida | 32610-0236 | — |
| Inpatient Research Clinic LLC | Hialeah | Florida | 33014 | — |
| Shands Jacksonville Medical Center Inc dba UF Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Cardiology Partners Clinical Research Institute | Loxahatchee Groves | Florida | 33470 | — |
| Baptist Hospital of Miami | Miami | Florida | 33173 | — |
| Advanced Research for Health Improvement | Naples | Florida | 34102 | — |
| Amavita Clinical Research (Dr. Pedro Martinez-Clark) | North Miami Beach | Florida | 33169 | — |
| South Florida Research Solutions LLC | Pembroke Pines | Florida | 33028 | — |
| Coastal Cardiology Consultants | Safety Harbor | Florida | 34695 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239-3513 | — |
| Tampa Cardiovascular Interventions and Research | Tampa | Florida | 33614 | — |
| Interventional Cardiac Consultants | Trinity | Florida | 34655 | — |
| Cardiology Partners Clinical Research Institute 1 | Wellington | Florida | 33449 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Atlanta Clinical Research Center | Cartersville | Georgia | 30121 | — |
| Northeast Georgia Heart Center | Gainesville | Georgia | 30501 | — |
| Cardiovascular Consultants of South Georgia LLC | Thomasville | Georgia | 31792 | — |
| Kootenai Medical Center | Coeur d'Alene | Idaho | 83814 | — |
| Insight Hospital and Medical Center Chicago | Chicago | Illinois | 60616 | — |
| Illinois Heart and Vascular Foundation | Chicago | Illinois | 60657 | — |
| Advocate Heart Institute | Downers Grove | Illinois | 60515 | — |
| Clinical Investigation Specialists, Inc. | Gurnee | Illinois | 60031 | — |
| Essential Concepts Research Solutions | Palos Hills | Illinois | 60465 | — |
| OSF HealthCare Cardiovascular Institute | Peoria | Illinois | 61614 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| Prairie Cardiovascular Consultants, Ltd. | Springfield | Illinois | 62701 | — |
| Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| Midwest Cardiovascular Research Foundation | Elkhart | Indiana | 46514-2487 | — |
| Northern Indiana Research Alliance | Fort Wayne | Indiana | 46804 | — |
| IU Health Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| Reid Health | Richmond | Indiana | 47374 | — |
| Health Midwest Ventures Group, Inc d b a HCA MidAmerica Division, LLC | Overland Park | Kansas | 66209 | — |
| University of Louisville | Louisville | Kentucky | 40202 | — |
| Norton Cardiovascular Associates | Louisville | Kentucky | 40205 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Cardiovascular Institute of the South | Houma | Louisiana | 70360 | — |
| Ochsner Clinic And Hospital | New Orleans | Louisiana | 70121 | — |
| Louisiana Heart Center | Slidell | Louisiana | 70458 | — |
| Monroe Research LLC | West Monroe | Louisiana | 71291 | — |
| Eastern Maine Medical Center Northeast Cardiology Associates | Bangor | Maine | 04401 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21231 | — |
| Suburban Hospital | Bethesda | Maryland | 20814 | — |
| Captiol Cardiology Associates | Lanham | Maryland | 20706 | — |
| Shady Grove Office | Rockville | Maryland | 20850 | — |
| Tidal Health Peninsula Regional Inc. | Salisbury | Maryland | 21801 | — |
| Pentucket Medical Associates | Haverhill | Massachusetts | 01830 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| St. Joseph Mercy Oakland | Bloomfield Hills | Michigan | 48302 | — |
| AAMRC | Flint | Michigan | 48504 | — |
| Jackson Heart Clinic | Jackson | Michigan | 39216 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912-1811 | — |
| St. Luke's Cardiology Associates | Duluth | Minnesota | 55802-2207 | — |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55102 | — |
| Mercy Medical Research Institute | Chesterfield | Missouri | 63017 | — |
| The Curators of the University of Missouri on behalf of University of Missouri Health Care | Columbia | Missouri | 65211 | — |
| North Kansas City Hospital | Kansas City | Missouri | 64116 | — |
| Spectrum Clinical Research | Kansas City | Missouri | 64118 | — |
| Cox Health | Springfield | Missouri | 65807 | — |
| Saint Louis University | St Louis | Missouri | 63110 | — |
| Bryan LGH Heart Institute | Lincoln | Nebraska | 68506 | — |
| Methodist Physicians Clinic Heart Consultants | Omaha | Nebraska | 68114 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Ash Research Clinic | Brick | New Jersey | 08724 | — |
| Englewood Health | Englewood | New Jersey | 07631 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Atlanticare Regional Medical Center | Pomona | New Jersey | 08240 | — |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | — |
| Buffalo General Medical Center | Buffalo | New York | 14203-1154 | — |
| Jamaica Hospital Medical Center | Jamaica | New York | 11418 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Weil Cornell University | New York | New York | 10065 | — |
| Weill Cornell Medicine | New York | New York | 10065 | — |
| Hudson Valley Cardiovascular Practice, PC | Poughkeepsie | New York | 12601 | — |
| Cardiac Care & Vascular Medicine, PLLC | The Bronx | New York | 10469 | — |
| Westchester Medical Center | Valhalla | New York | 10532 | — |
| Clinical Trials of America 1 | Cary | North Carolina | 27518 | — |
| UNC School of Medicine | Chapel Hill | North Carolina | 27599-5021 | — |
| The Moses H. Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Atrium Health Wake Forest Baptist | High Point | North Carolina | 27262 | — |
| Clinical Trials of America | Lenoir | North Carolina | 28645 | — |
| Novant Health | Matthews | North Carolina | 28105 | — |
| Rex Hospital | Raleigh | North Carolina | 27607 | — |
| Sanford Cardiology | Sanford | North Carolina | 27330 | — |
| Trinity Medical Group | Minot | North Dakota | 58701 | — |
| Summa Health System | Akron | Ohio | 44304 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Metro Health Hospital | Cleveland | Ohio | 44109 | — |
| Ohio Health | Columbus | Ohio | 43214 | — |
| Kettering Medical Center | Kettering | Ohio | 45429 | — |
| The Heart House | Springfield | Ohio | 45504 | — |
| Ascension Medical Group - St. John Clinic Infectious Disease | Bartlesville | Oklahoma | 74006 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| St John Health System Inc | Tulsa | Oklahoma | 74104 | — |
| Advanced Cardiac Care | Bethlehem | Pennsylvania | 18017 | — |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| Hamot Medical Center | Erie | Pennsylvania | 16507 | — |
| UPMC Pinnacle Health | Harrisburg | Pennsylvania | 17110 | — |
| St. Mary Medical Center | Langhorne | Pennsylvania | 19047 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Lankenau Institute for Medical Research | Wynnewood | Pennsylvania | 19096 | — |
| AnMed Health | Anderson | South Carolina | 29621 | — |
| Prisma Health | Greenville | South Carolina | 29065 | — |
| St. Francis Physician Services, Inc, DBA Upstate Cardiology Research | Greenville | South Carolina | 29607 | — |
| Carolina Cardiology Associates | Rock Hill | South Carolina | 29732 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Erlanger Health System | Chattanooga | Tennessee | 37403 | — |
| Apex Cardiology | Jackson | Tennessee | 38301 | — |
| Ascension Saint Thomas West Hospital | Nashville | Tennessee | 37205 | — |
| Vanderbilt University | Nashville | Tennessee | 37232 | — |
| Parkway Cardiology Associates PC | Oak Ridge | Tennessee | 37830 | — |
| Amarillo Heart Clinical Research Institute | Amarillo | Texas | 79106 | — |
| PharmaTex Research | Amarillo | Texas | 79109 | — |
| Med Research, Inc. | El Paso | Texas | 79902 | — |
| Texas Tech University Health Sciences Center-El Paso | El Paso | Texas | 79905 | — |
| Baylor Scott and White Research Institute 1 | Fort Worth | Texas | 76104 | — |
| East Texas Cardiology, PA | Houston | Texas | 77002 | — |
| Physician Research Network | Houston | Texas | 77027 | — |
| Vital Heart and Vein | Humble | Texas | 77338 | — |
| Texas Cardiology Research Center | Kingwood | Texas | 77339 | — |
| Ascension Texas Cardiovascular | Kyle | Texas | 78640 | — |
| Cardiovoyage | Sherman | Texas | 75090 | — |
| Northwest Heart Clinical Research, LLC. | Tomball | Texas | 77375 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| Riverside Regional Medical Center | Newport News | Virginia | 23601 | — |
| Sentara Cardiovascular Research Institute | Norfolk | Virginia | 23507 | — |
| Winchester Medical Center | Winchester | Virginia | 22601 | — |
| Providence Regional Medical Center Everett | Everett | Washington | 98201 | — |
| Cardiac Surgery Group | Tacoma | Washington | 98405 | — |
| MultiCare Health System | Tacoma | Washington | 98405 | — |
| Mayo Clinic Health System | La Crosse | Wisconsin | 54601-4795 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 841 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05754957, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 6, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05754957 live on ClinicalTrials.gov.