ClinicalTrials.gov record
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
ClinicalTrials.gov ID: NCT05757869
Public ClinicalTrials.gov record NCT05757869. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 9:42 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel Group, Active-Controlled Study to Evaluate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, Versus Apixaban in Participants With Atrial Fibrillation
Study identification
- NCT ID
- NCT05757869
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 20,284 participants
Conditions and interventions
Conditions
Interventions
- Apixaban Drug
- Apixaban Placebo Drug
- Milvexian Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 10, 2023
- Primary completion
- Oct 30, 2026
- Completion
- Oct 30, 2026
- Last update posted
- May 7, 2026
2023 – 2026
United States locations
- U.S. sites
- 216
- U.S. states
- 38
- U.S. cities
- 185
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular, LLC | Alexander City | Alabama | 35010 | — |
| Ascension St. Vincent's Health System | Birmingham | Alabama | 35205 | — |
| SEC Clinical Research | Dothan | Alabama | 36303 | — |
| HH Heart Center and Heart Center | Huntsville | Alabama | 35801 | — |
| CB Flock Research Corporation | Mobile | Alabama | 36608 | — |
| Mercy Gilbert Medical Center | Gilbert | Arizona | 85297 | — |
| Valleywise Health Medical Center | Phoenix | Arizona | 85008 | — |
| Arizona Arrhythmia Research Center | Phoenix | Arizona | 85016 | — |
| Arizona Heart Hospital | Phoenix | Arizona | 85016 | — |
| HonorHealth Neurology 1 | Scottsdale | Arizona | 85251 | — |
| HonorHealth Neurology | Scottsdale | Arizona | 85251 | — |
| Arkansas Heart Hospital | Little Rock | Arkansas | 72211 | — |
| Bakersfield Memorial Hospital | Bakersfield | California | 93301 | — |
| Vitality Clinical Research | Beverly Hills | California | 90211 | — |
| Chula Vista Cardiac Clinic | Chula Vista | California | 91910 | — |
| Sharp Chula Vista Medical Center | Chula Vista | California | 91911 | — |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | — |
| Paradise Clinical Research Group LLC | Glendora | California | 91741 | — |
| Miller Children's at Long Beach Medical Center | Long Beach | California | 90806 | — |
| Los Angeles Cardiology Associates | Los Angeles | California | 90017 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Merced Vein and Vascular Center | Merced | California | 95340 | — |
| Radin Cardiovascular Medical Group | Newport Beach | California | 92663 | — |
| California Medical Research Associates, Inc. | Northridge | California | 91324 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Health Care | Palm Springs | California | 92262 | — |
| Havana Research Institute LLC | Pasadena | California | 91105 | — |
| Eisenhower Desert Cardiology Center | Rancho Mirage | California | 92270 | — |
| Stanford Health Care | Redwood City | California | 94063 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Ramin Manshadi, MD | Stockton | California | 95204 | — |
| UCLA School of Medicine | Torrance | California | 90502 | — |
| Cardiology Associates Medical Group | Ventura | California | 93003 | — |
| North County Internal Medicine | Vista | California | 92083 | — |
| John Muir Physician Network Clin. Research Center | Walnut Creek | California | 94598 | — |
| Aurora Denver Cardiology Associates | Aurora | Colorado | 80012 | — |
| Aurora Denver Cardiology Associates 1 | Denver | Colorado | 80218 | — |
| Paradigm Clinical Research Centers, Inc. | Wheat Ridge | Colorado | 80033 | — |
| Bridgeport Hospital | Bridgeport | Connecticut | 06610 | — |
| Western Connecticut Health Network/Danbury Hospital | Danbury | Connecticut | 06810 | — |
| Cardiology Associates of Fairfield County | Stamford | Connecticut | 06905 | — |
| PriMed Physicians, A Member of NE Medical Group | Trumbull | Connecticut | 06611 | — |
| Cardiology Physicians | Newark | Delaware | 19713 | — |
| George Washington University School of Medicine | Washington D.C. | District of Columbia | 20037 | — |
| Orlando Heart Specialists | Altamonte Springs | Florida | 32714 | — |
| Bay Area Cardiology Associates, P.A. - Brandon Office | Brandon | Florida | 33511 | — |
| Clearwater Cardiovascular Consultants | Clearwater | Florida | 33756 | — |
| Cardiology Consultants | Daytona Beach | Florida | 32114 | — |
| Cardiology Associates Research Company | Daytona Beach | Florida | 32117 | — |
| Accel Research Sites | DeLand | Florida | 32720 | — |
| The Cardiac & Vascular Institute Research Foundation | Gainesville | Florida | 32605 | — |
| University of Florida College of Medicine | Gainesville | Florida | 32610-0226 | — |
| East Coast Institute for Research | Jacksonville | Florida | 32216 | — |
| Watson Clinic | Lakeland | Florida | 33805 | — |
| Clearwater Cardiovascular Consultants 1 | Largo | Florida | 33777 | — |
| Miami Clinical Research | Miami | Florida | 33155 | — |
| Reliant Medical Research | Miami | Florida | 33165 | — |
| Suncoast Research Associates, LLC | Miami | Florida | 33173 | — |
| Ascension Sacred Heart Hospital | Miramar Beach | Florida | 32550 | — |
| Suncoast Clinical Research | New Port Richey | Florida | 34652 | — |
| Central Florida Medical Associates | Orange City | Florida | 32763-9116 | — |
| Cardiology Partners Clinical Research Institute | Palm Beach Gardens | Florida | 33410 | — |
| Cardiology Consultants 1 | Pensacola | Florida | 32501 | — |
| North Broward Hospital District | Pompano Beach | Florida | 33064 | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | — |
| Coastal Cardiology Consultants | Safety Harbor | Florida | 34695 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239-3513 | — |
| Heart and Vascular Institute of Florida | St. Petersburg | Florida | 33705 | — |
| University of South Florida | Tampa | Florida | 33606 | — |
| Adtremed Inc | Tampa | Florida | 33607 | — |
| Florida Hospital Tampa | Tampa | Florida | 33613 | — |
| Helping Hands Health Center dba Helping Hands Evolution Research | Tampa | Florida | 33634 | — |
| Cardiology Partners Clinical Research Institute 1 | Wellington | Florida | 33449 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Piedmont Heart Institute 1 | Atlanta | Georgia | 30309 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Atlanta Heart Specialists | Cumming | Georgia | 30041 | — |
| Northeast Georgia Heart Center | Gainesville | Georgia | 30501 | — |
| Cardiology Consultants of South Georgia Inc | Thomasville | Georgia | 31792 | — |
| The Queens Medical Center | Honolulu | Hawaii | 96813 | — |
| Kootenai Medical Center | Coeur d'Alene | Idaho | 83814 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| Chicago Medical Research, LLC | Hazel Crest | Illinois | 60429 | — |
| Midwest Cardiovascular Institute | Naperville | Illinois | 60540 | — |
| Prairie Education And Research Cooperative | O'Fallon | Illinois | 62269 | — |
| Advocate Heart Institute | Oak Lawn | Illinois | 60453 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| Blessing Hospital | Quincy | Illinois | 62301 | — |
| OSF HealthCare Cardiovascular Institute | Rockford | Illinois | 61107-5059 | — |
| Springfield Clinic 1st | Springfield | Illinois | 62702 | — |
| Bloomington Hospital | Bloomington | Indiana | 47402 | — |
| St. Vincent Medical Group, Inc. | Indianapolis | Indiana | 46260 | — |
| IU Health Ball Memorial Hospital | Muncie | Indiana | 47303 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| St. Elizabeth Physicians | Crittenden | Kentucky | 41030 | — |
| Kentuckyone Health Neurology Associates | Louisville | Kentucky | 40202 | — |
| Owensboro Medical Practice | Owensboro | Kentucky | 42303 | — |
| Cambridge Medical Trials | Alexandria | Louisiana | 71301 | — |
| Grace Research, LLC - Bossier City | Bossier City | Louisiana | 71111 | — |
| Medical Research Specialists | Chalmette | Louisiana | 70043 | — |
| Cardiovascular Institute of the South | Houma | Louisiana | 70360 | — |
| Tulane University School of Medicine | New Orleans | Louisiana | 70112 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| Louisiana State University Health Sciences Center | Shreveport | Louisiana | 71103 | — |
| Pierremont Cardiology | Shreveport | Louisiana | 71115 | — |
| Clinical Trials of America 1 | West Monroe | Louisiana | 71291 | — |
| Luminis Health Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| Suburban Hospital | Bethesda | Maryland | 20814 | — |
| Johns Hopkins University | Columbia | Maryland | 21044 | — |
| Shady Grove Office | Rockville | Maryland | 20850 | — |
| Tidal Health Peninsula Regional Inc. | Salisbury | Maryland | 21804 | — |
| Spectrum Clinical Research, Inc. | Towson | Maryland | 21204 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Flint Clinical Research | Flint | Michigan | 48503 | — |
| Sparrow Clinical Research Institute | Lansing | Michigan | 48912 | — |
| Michigan Heart & Vascular Institute | Petoskey | Michigan | 49770 | — |
| Revival Research Institute LLC | Southgate | Michigan | 48195 | — |
| Oakland Medical Research | Troy | Michigan | 48085 | — |
| Trinity Health Michigan d b a Michigan Heart | Ypsilanti | Michigan | 48197 | — |
| HealthPartners Institute | Bloomington | Minnesota | 55426 | — |
| Essentia Health SMDC | Duluth | Minnesota | 55805 | — |
| Fairview Health System | Maplewood | Minnesota | 55109 | — |
| Mississippi Baptist Health Systems | Jackson | Mississippi | 39202 | — |
| Olive Branch Family Medical Center | Olive Branch | Mississippi | 38654 | — |
| Cardiology Associates of North Mississippi | Tupelo | Mississippi | 38801 | — |
| The Curators of the University of Missouri on behalf of University of Missouri Health Care | Columbia | Missouri | 65211 | — |
| Washington University School Of Medicine | St Louis | Missouri | 63110 | — |
| St. Louis Heart and Vascular | St Louis | Missouri | 63136 | — |
| Advanced Heart Care, LLC | Bridgewater | New Jersey | 08807 | — |
| Cardiovascular Associates of the Delaware Valley | Haddon Heights | New Jersey | 08035 | — |
| Virtua Medical Group, PA | Marlton | New Jersey | 08053 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| NYU Hudson Valley Cardiology | Cortlandt Manor | New York | 10567 | — |
| Jamaica Hospital Medical Center | Jamaica | New York | 11418 | — |
| Westchester Medical Center Advanced Physician Services PC | Kingston | New York | 12401 | — |
| Laurelton Heart Specialist, PC | Laurelton | New York | 11413 | — |
| Crystal Run Healthcare LLP | Middletown | New York | 10941 | — |
| NYU Langone Hospital Long Island | Mineola | New York | 11501 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Cardiac Care & Vascular Medicine, PLLC | The Bronx | New York | 10469 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| Guilford Neurologic Associates | Greensboro | North Carolina | 27405 | — |
| Clinical Trials of America | Lenoir | North Carolina | 28645 | — |
| Pinehurst Medical Clinic Inc | Pinehurst | North Carolina | 28374 | — |
| Rex Hospital | Raleigh | North Carolina | 27607 | — |
| Sanford Cardiology | Sanford | North Carolina | 27330 | — |
| Wilmington Health Associates | Wilmington | North Carolina | 28401 | — |
| Trinity Medical Group | Minot | North Dakota | 58701 | — |
| Summa Health System | Akron | Ohio | 44304 | — |
| The Lindner Clinical Trial Center | Cincinnati | Ohio | 45219 | — |
| Louis Stokes Cleveland VA Med Ctr | Cleveland | Ohio | 44106 | — |
| The MetroHealth System | Cleveland | Ohio | 44109 | — |
| Dayton Heart Center | Dayton | Ohio | 45414 | — |
| Advanced Medical Research | Maumee | Ohio | 43537 | — |
| The Heart House | Springfield | Ohio | 45505 | — |
| Genesis HealthCare System | Zanesville | Ohio | 43701 | — |
| Ascension Medical Group - St. John Clinic Infectious Disease | Bartlesville | Oklahoma | 74006 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| St John Health System Inc | Tulsa | Oklahoma | 74104 | — |
| Providence Heart Clinic | Portland | Oregon | 97225 | — |
| Chambersburg Hospital | Chambersburg | Pennsylvania | 17201 | — |
| Hamot Medical Center | Erie | Pennsylvania | 16507 | — |
| Capital Area Research | Newport | Pennsylvania | 17074 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Hudson Valley Cardiovascular Practice, PC | Pittsburgh | Pennsylvania | 15213 | — |
| VA Pittsburgh Healthcare System | Pittsburgh | Pennsylvania | 15240 | — |
| Donald Guthrie Foundation | Sayre | Pennsylvania | 18840 | — |
| Geisinger Medical Center | Scranton | Pennsylvania | 18510 | — |
| Cardiology Consultants of Philadelphia | Yardley | Pennsylvania | 19067 | — |
| York Hospital | York | Pennsylvania | 17403-3676 | — |
| AnMed Health | Anderson | South Carolina | 29621 | — |
| Internal Medicine Associates of Anderson | Anderson | South Carolina | 29621 | — |
| MUSC Health Heart Vascular Columbia Medical Park DT III | Columbia | South Carolina | 29204 | — |
| St. Francis Physician Services, Inc, DBA Upstate Cardiology Research | Greenville | South Carolina | 29607 | — |
| Black Hills Cardiovascular Research | Rapid City | South Dakota | 57701 | — |
| Jackson Clinic | Jackson | Tennessee | 38301 | — |
| Jackson Madison County General Hospital | Jackson | Tennessee | 38301 | — |
| Wellmont CVA Heart Institute | Johnson | Tennessee | 37604 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| East Tennessee Heart Consultants | Knoxville | Tennessee | 37923-4310 | — |
| Saint Thomas Health | Nashville | Tennessee | 37205 | — |
| Cardiovascular Associates | Powell | Tennessee | 37849 | — |
| PharmaTex Research | Amarillo | Texas | 79109 | — |
| Amarillo Heart Clinical Research Institute | Amarillo | Texas | 79124 | — |
| Ascension Texas Cardiovascular | Austin | Texas | 78705 | — |
| Baylor Research Institute | Dallas | Texas | 75204 | — |
| Texas Health Dallas | Dallas | Texas | 75231 | — |
| Plaza Medical Center of Fort Worth | Fort Worth | Texas | 76104 | — |
| East Texas Cardiology, PA | Houston | Texas | 77002 | — |
| Primecare Medical Group | Houston | Texas | 77024 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Novel Research LLC | Houston | Texas | 77077 | — |
| West Houston Area Clinical Trial Consultants LLC | Katy | Texas | 77493 | — |
| Texas Cardiology Research Center | Kingwood | Texas | 77339 | — |
| Odessa Heart Institute | Odessa | Texas | 79761 | — |
| Sun Research Institute | San Antonio | Texas | 78215 | — |
| Southwest Medical Clinic | Sugar Land | Texas | 77479 | — |
| Northwest Houston Clinical Research | Tomball | Texas | 77375 | — |
| Baylor Scott and White Research Institute | Waco | Texas | 76712 | — |
| Alpine Research Organization | Farmington | Utah | 84025 | — |
| Burke Internal Medicine and Research | Burke | Virginia | 22015 | — |
| Roanoke Heart Institute PLC | Roanoke | Virginia | 24014 | — |
| Providence Regional Medical Center Everett | Everett | Washington | 98201 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Universal Research Group, LLC | Tacoma | Washington | 98405 | — |
| Wausau Hospital | Wausau | Wisconsin | 54401 | — |
| Allegiance Reserach Specialists, LLC | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 836 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05757869, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05757869 live on ClinicalTrials.gov.