ClinicalTrials.gov record
A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen
ClinicalTrials.gov ID: NCT05769608
Public ClinicalTrials.gov record NCT05769608. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo Controlled, Parallel Arm, Multicenter, Phase 2 Study to Evaluate the Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Medication Regimen
Study identification
- NCT ID
- NCT05769608
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Mineralys Therapeutics Inc.
- Industry
- Enrollment
- 285 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- lorundrostat Dose 1 Drug
- lorundrostat Dose 2 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 12, 2023
- Primary completion
- Jan 14, 2025
- Completion
- Jan 14, 2025
- Last update posted
- Jan 19, 2026
2023 – 2025
United States locations
- U.S. sites
- 104
- U.S. states
- 27
- U.S. cities
- 91
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cardiology, P.C. - Birmingham | Birmingham | Alabama | 35211 | — |
| University of Alabama at Birmingham (UAB) - Vascular Biology and Hypertension Program | Birmingham | Alabama | 35294 | — |
| Chandler Clinical Trials | Chandler | Arizona | 85224 | — |
| Brown Road Family Medicine | Mesa | Arizona | 85213 | — |
| Scottsdale Clinical Trials (Elite Clinical Network) | Scottsdale | Arizona | 85260 | — |
| Fiel Family & Sports Medicine | Tempe | Arizona | 85383 | — |
| Noble Clinical Research | Tucson | Arizona | 85704 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| The Medical Research Group Inc. | Fresno | California | 93720 | — |
| Marvel Clinical Research | Huntington Beach | California | 92647 | — |
| University of California San Diego (UCSD) - Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California | 92037 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Catalina Research Institute | Montclair | California | 91763 | — |
| Northridge Clinical Trials | Northridge | California | 91325 | — |
| University of California Irvine Medical Center | Orange | California | 92868 | — |
| Triwest Research Associates | San Diego | California | 92108 | — |
| San Jose Clinical Trials | San Jose | California | 95117 | — |
| Blue Coast Research Center | Vista | California | 92081 | — |
| Accelerated Enrollment Solutions (AES)- Vista | Vista | California | 92083 | — |
| Delta Waves, Inc. | Colorado Springs | Colorado | 80918 | — |
| CMR of Greater New Haven | Hamden | Connecticut | 06517 | — |
| Indago Research & Health Center, Inc. | Hialeah | Florida | 33012 | — |
| Clinical Neuroscience Solutions, Inc (Jacksonville) | Jacksonville | Florida | 32256 | — |
| Reserka, LLC | Miami | Florida | 33176 | — |
| Nuovida Research Center Corp | Miami | Florida | 33186 | — |
| Clinical Neuroscience Solutions, INC. | Orlando | Florida | 32801 | — |
| Patron Medical - Andres Patron D.O. (Patron Ventures, LLC) | Pembroke | Florida | 33026 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Clinical Research of West Florida, Inc. | Tampa | Florida | 33606 | — |
| The Pierone Research Institute (Elligo Health Research) | Vero Beach | Florida | 32960 | — |
| Nephrology Associates, PC - Downtown Augusta | Augusta | Georgia | 30901 | — |
| Accel Research Sites | Decatur | Georgia | 30030 | — |
| Georgia Clinical Research, LLC | Lawrenceville | Georgia | 30044 | — |
| Randomize Now | Peachtree City | Georgia | 30269 | — |
| Alta Pharmaceutical Research Center | Peachtree Corners | Georgia | 30092 | — |
| Fellows Research Alliance, Inc | Savannah | Georgia | 31406 | — |
| Eagle Clinical Research | Chicago | Illinois | 60621 | — |
| The University of Chicago Medicine | Chicago | Illinois | 60637 | — |
| GenHarp Clinical Solutions | Evergreen Park | Illinois | 60805 | — |
| Southern Illinois School of Medicine | Springfield | Illinois | 62702 | — |
| Franciscan Physician Network-Indiana Heart Physicians | Indianapolis | Indiana | 46237 | — |
| Indiana Clinical Research | Merrillville | Indiana | 46410 | — |
| The Research Group of Lexington, LLC | Lexington | Kentucky | 40503 | — |
| Advanced Internal Medicine, PLLC (Elligo Health Research) | Paducah | Kentucky | 42001 | — |
| Versailles Family Medicine | Versailles | Kentucky | 40383 | — |
| Cambridge Clinical Trials | Alexandria | Louisiana | 71301 | — |
| Pennington Biomedical Research Center | Baton Rouge | Louisiana | 70808 | — |
| Boston Clinical Trials | Boston | Massachusetts | 02131 | — |
| ActivMed Practices & Research, LLC | Methuen | Massachusetts | 01844 | — |
| Saint Louis University | St Louis | Missouri | 63104 | — |
| Quality Clinical Research Inc. (QCR) - Omaha | Omaha | Nebraska | 68114 | — |
| Henderson Clinical Trials | Henderson | Nevada | 89052 | — |
| Las Vegas Clinical Trials | Las Vegas | Nevada | 89030 | — |
| Oasis Clinical Trials | Las Vegas | Nevada | 89121 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Seacoast Kidney & Hypertension Specialist | Portsmouth | New Hampshire | 03801 | — |
| Albany Medical College Div of Community Endocrinology | Albany | New York | 12203 | — |
| University of Buffalo | Buffalo | New York | 14215 | — |
| Columbia University | New York | New York | 10032 | — |
| Marian David, MD, PC (Elligo Health Research) | New York | New York | 11415 | — |
| Triad Internal Medicine | Asheboro | North Carolina | 27205 | — |
| Asheville Clinical Trials (Elite Clinical Network) | Asheville | North Carolina | 28803 | — |
| Duke University Medical Center Heart Center Clinical Research Unit | Durham | North Carolina | 27710 | — |
| East Carolina University (ECU) Physicians - East Carolina Heart Institute - East Carolina University Location | Greenville | North Carolina | 27834 | — |
| Lucas Research, Inc. | New Bern | North Carolina | 28557 | — |
| Iredell Memorial Hospital, Inc (Elligo Health Research) | Statesville | North Carolina | 28677 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Research Innovations (Elligo Health Research) | Beavercreek | Ohio | 45431 | — |
| Diabetes and Endocrinology Associates of Stark County, Inc. | Canton | Ohio | 44718 | — |
| Intrepid Research | Cincinnati | Ohio | 45245 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Centricity Research (Aventiv Research) - Women's Health | Dublin | Ohio | 43016 | — |
| STAT Research | Springboro | Ohio | 45066 | — |
| Williamette Valley Clincial Studies | Eugene | Oregon | 97404 | — |
| AMS Cardiology | Horsham | Pennsylvania | 19044 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Accelerated Enrollment Solutions (AES)- Anderson | Anderson | South Carolina | 29621 | — |
| WR- Notus Clinical Trials, LLC | Charleston | South Carolina | 29414 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| Chattanooga Medical Research | Chattanooga | Tennessee | 37404 | — |
| Lifedoc Research | Memphis | Tennessee | 38115 | — |
| Clinical Neuroscience Solutions, Inc | Memphis | Tennessee | 38119 | — |
| Vanderbilt University Medical Center (VUMC) | Nashville | Tennessee | 37232 | — |
| Elligo Health Research | Austin | Texas | 78704 | — |
| Punzi Medical Center | Carrollton | Texas | 75006 | — |
| David Turbay, MD, PLLC (Elligo Health Research) | El Paso | Texas | 79905 | — |
| Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| Juno Research LLC | Houston | Texas | 77040 | — |
| Gulf Coast Clinical Research | Houston | Texas | 77070 | — |
| Medical Colleagues of Texas, LLP (Elligo Health Research) | Katy | Texas | 77450 | — |
| Synergy Groups Medical - Bissonet Site | Katy | Texas | 77494 | — |
| PRX Research - Mesquite | Mesquite | Texas | 75149 | — |
| Medical Colleagues of Texas, LLP (Elligo Health Research) | Paris | Texas | 75462 | — |
| ACRC Trials | Plano | Texas | 75024 | — |
| Clinical Investigations of Texas (CIT) | Plano | Texas | 75075 | — |
| Sun Research Institute (SRI) - San Antonio | San Antonio | Texas | 78215 | — |
| San Antonio Clinical Trials | San Antonio | Texas | 78240 | — |
| Sugar Lakes Family Practice (Elligo Health Research) | Sugar Land | Texas | 77479 | — |
| The University of Utah | Salt Lake City | Utah | 84108 | — |
| Burke Internal Medicine | Burke | Virginia | 22015 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Eastern Virginia Medical School | Norfolk | Virginia | 23510 | — |
| Centricity Research (IACT Health) (Hampton Roads Center For Clinical Research, Inc.)) - Suffolk Multispecialty Research | Suffolk | Virginia | 23435 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05769608, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 19, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05769608 live on ClinicalTrials.gov.