A Trial of Setmelanotide in Acquired Hypothalamic Obesity
Public ClinicalTrials.gov record NCT05774756. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Double Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Setmelanotide in Patients With Acquired Hypothalamic Obesity
Study identification
- NCT ID
- NCT05774756
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Rhythm Pharmaceuticals, Inc.
- Industry
- Enrollment
- 143 participants
Conditions and interventions
Conditions
Interventions
- Setmelanotide Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 4 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 25, 2023
- Primary completion
- Mar 17, 2025
- Completion
- Apr 15, 2027
- Last update posted
- May 28, 2026
2023 – 2027
United States locations
- U.S. sites
- 16
- U.S. states
- 14
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAN Pediatric Endocrinology | Birmingham | Alabama | 35233 | — |
| Rady Children's Hospital | San Diego | California | 92123 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| University of Florida | Gainesville | Florida | 32610-0296 | — |
| Ann and Robert H. Lurie Children's Hospital | Chicago | Illinois | 60611 | — |
| University of Iowa Stead Family Department of Pediatrics | Iowa City | Iowa | 52242 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Children's Minnesota | Saint Paul | Minnesota | 55102 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 100029 | — |
| Columbia University Irving Medical Center | New York | New York | 10032 | — |
| Ohio State Wexner Medical Center | Columbus | Ohio | 43203 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73122 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Vanderbilt University School of Medicine | Nashville | Tennessee | 37232 | — |
| Seattle Children's Hospital, Research and Foundation - Center for Integrative Brain Research | Seattle | Washington | 98101 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05774756, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 28, 2026 · Synced Jul 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05774756 live on ClinicalTrials.gov.