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Recruiting Phase 3 Interventional

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

ClinicalTrials.gov ID: NCT05774951

Public ClinicalTrials.gov record NCT05774951. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

CAMBRIA-1: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy With Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) Versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients With ER+/HER2- Early Breast Cancer and an Intermediate or High Risk of Recurrence Who Have Completed Definitive Locoregional Therapy and at Least 2 Years of Standard Adjuvant Endocrine-Based Therapy Without Disease Recurrence

Study identification

NCT ID
NCT05774951
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
4,300 participants

Conditions and interventions

Interventions

  • Anastrozole Drug
  • Camizestrant Drug
  • Exemestane Drug
  • Letrozole Drug
  • Tamoxifen Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 130 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 30, 2023
Primary completion
Apr 19, 2027
Completion
May 28, 2036
Last update posted
May 7, 2026

2023 – 2036

United States locations

U.S. sites
126
U.S. states
39
U.S. cities
113
Facility City State ZIP Site status
Research Site Birmingham Alabama 35205 Active, not recruiting
Research Site Dothan Alabama 36303 Active, not recruiting
Research Site Anchorage Alaska 99508 Active, not recruiting
Research Site Chandler Arizona 85224 Active, not recruiting
Research Site Hot Springs Arkansas 71913 Active, not recruiting
Research Site Anaheim California 92801 Active, not recruiting
Research Site Beverly Hills California 90211 Active, not recruiting
Research Site Concord California 94520 Active, not recruiting
Research Site Corona California 92882 Active, not recruiting
Research Site Fountain Valley California 92708 Active, not recruiting
Research Site Greenbrae California 94904 Active, not recruiting
Research Site Los Alamitos California 90720 Active, not recruiting
Research Site Palo Alto California 94304 Active, not recruiting
Research Site San Diego California 92121 Active, not recruiting
Research Site San Diego California 92123 Active, not recruiting
Research Site Whittier California 90603 Active, not recruiting
Research Site Aurora Colorado 80045 Withdrawn
Research Site Hartford Connecticut 06102 Active, not recruiting
Research Site Fort Myers Florida 33901 Active, not recruiting
Research Site Gainesville Florida 32603 Active, not recruiting
Research Site Miami Beach Florida 33140 Active, not recruiting
Research Site Orlando Florida 32806 Active, not recruiting
Research Site Plantation Florida 33324 Active, not recruiting
Research Site Port Saint Lucie Florida 34952 Active, not recruiting
Research Site Saint Augustine Florida 32086 Active, not recruiting
Research Site St. Petersburg Florida 33705 Active, not recruiting
Research Site St. Petersburg Florida 33709 Active, not recruiting
Research Site Tallahassee Florida 32308 Active, not recruiting
Research Site West Palm Beach Florida 33401 Active, not recruiting
Research Site Winter Haven Florida 33880 Active, not recruiting
Research Site Atlanta Georgia 30310 Active, not recruiting
Research Site Atlanta Georgia 30318 Active, not recruiting
Research Site Columbus Georgia 31904 Active, not recruiting
Research Site Honolulu Hawaii 96813 Withdrawn
Research Site Chicago Illinois 60608 Withdrawn
Research Site Chicago Illinois 60637 Active, not recruiting
Research Site Decatur Illinois 62526 Active, not recruiting
Research Site Elmhurst Illinois 60126 Active, not recruiting
Research Site Hinsdale Illinois 60521 Active, not recruiting
Research Site Park Ridge Illinois 60068 Active, not recruiting
Research Site Fort Wayne Indiana 46804 Active, not recruiting
Research Site Iowa City Iowa 52242 Active, not recruiting
Research Site Fort Mitchell Kentucky 41017 Active, not recruiting
Research Site Lexington Kentucky 40536 Active, not recruiting
Research Site Louisville Kentucky 40202 Active, not recruiting
Research Site Baton Rouge Louisiana 70809 Active, not recruiting
Research Site Brewer Maine 04412 Withdrawn
Research Site Scarborough Maine 04074 Withdrawn
Research Site Frederick Maryland 21702 Active, not recruiting
Research Site Glenn Dale Maryland 20769 Active, not recruiting
Research Site Silver Spring Maryland 20910 Active, not recruiting
Research Site Towson Maryland 21204 Active, not recruiting
Research Site Boston Massachusetts 02111 Withdrawn
Research Site Hyannis Massachusetts 02601 Active, not recruiting
Research Site Ann Arbor Michigan 48109 Active, not recruiting
Research Site Detroit Michigan 48202 Active, not recruiting
Research Site East Lansing Michigan 48824 Active, not recruiting
Research Site Lansing Michigan 48910 Active, not recruiting
Research Site Royal Oak Michigan 48073 Active, not recruiting
Research Site Independence Missouri 64057 Active, not recruiting
Research Site Lincoln Nebraska 68506 Active, not recruiting
Research Site Las Vegas Nevada 89148 Terminated
Research Site Laconia New Hampshire 03246 Active, not recruiting
Research Site Belleville New Jersey 07109 Active, not recruiting
Research Site Farmington New Mexico 87401 Active, not recruiting
Research Site Santa Fe New Mexico 87505 Active, not recruiting
Research Site East Syracuse New York 13057 Active, not recruiting
Research Site New Hyde Park New York 11042 Withdrawn
Research Site New York New York 10011 Active, not recruiting
Research Site New York New York 10019 Withdrawn
Research Site New York New York 10029 Active, not recruiting
Research Site Stony Brook New York 11794 Active, not recruiting
Research Site The Bronx New York 10461 Active, not recruiting
Research Site White Plains New York 10601 Active, not recruiting
Research Site Charlotte North Carolina 28204 Active, not recruiting
Research Site Durham North Carolina 27710-0001 Active, not recruiting
Research Site Greensboro North Carolina 27403 Withdrawn
Research Site Raleigh North Carolina 27607 Active, not recruiting
Research Site Rocky Mount North Carolina 27804 Active, not recruiting
Research Site Winston-Salem North Carolina 27103 Recruiting
Research Site Winston-Salem North Carolina 27104 Recruiting
Research Site Cincinnati Ohio 45219 Withdrawn
Research Site Cincinnati Ohio 45255 Active, not recruiting
Research Site Cleveland Ohio 44106 Active, not recruiting
Research Site Cleveland Ohio 44195 Active, not recruiting
Research Site Youngstown Ohio 44504 Withdrawn
Research Site Clairton Pennsylvania 15025 Active, not recruiting
Research Site Philadelphia Pennsylvania 19106 Active, not recruiting
Research Site Philadelphia Pennsylvania 19111 Active, not recruiting
Research Site Pittsburgh Pennsylvania 15213 Active, not recruiting
Research Site Reading Pennsylvania 19611 Active, not recruiting
Research Site State College Pennsylvania 16803 Terminated
Research Site Providence Rhode Island 02903 Active, not recruiting
Research Site Lancaster South Carolina 29720 Withdrawn
Research Site Spartanburg South Carolina 29303 Active, not recruiting
Research Site Aberdeen South Dakota 57401 Recruiting
Research Site Mitchell South Dakota 57301 Active, not recruiting
Research Site Pierre South Dakota 57501 Recruiting
Research Site Sioux Falls South Dakota 57105 Active, not recruiting
Research Site Yankton South Dakota 57078 Active, not recruiting
Research Site Chattanooga Tennessee 37404 Active, not recruiting
Research Site Knoxville Tennessee 37920 Active, not recruiting
Research Site Nashville Tennessee 37203 Active, not recruiting
Research Site Nashville Tennessee 37204 Active, not recruiting
Research Site Austin Texas 78731 Withdrawn
Research Site Dallas Texas 75230 Active, not recruiting
Research Site Denton Texas 76201 Active, not recruiting
Research Site Houston Texas 77024 Active, not recruiting
Research Site Houston Texas 77030 Active, not recruiting
Research Site Irving Texas 75063 Recruiting
Research Site Ogden Utah 84405 Active, not recruiting
Research Site Salt Lake City Utah 84106 Active, not recruiting
Research Site Fairfax Virginia 22031 Active, not recruiting
Research Site Lynchburg Virginia 24501 Active, not recruiting
Research Site Midlothian Virginia 23114 Active, not recruiting
Research Site Reston Virginia 20190 Active, not recruiting
Research Site Richmond Virginia 23235 Active, not recruiting
Research Site Seattle Washington 98101 Active, not recruiting
Research Site Seattle Washington 98104 Active, not recruiting
Research Site Spokane Washington 99202 Active, not recruiting
Research Site Tacoma Washington 98405 Active, not recruiting
Research Site Charleston West Virginia 25304 Withdrawn
Research Site Morgantown West Virginia 26505 Active, not recruiting
Research Site Appleton Wisconsin 54911 Withdrawn
Research Site Madison Wisconsin 53792 Active, not recruiting
Research Site Milwaukee Wisconsin 53226 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 572 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05774951, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05774951 live on ClinicalTrials.gov.

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