Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients

ClinicalTrials.gov ID: NCT05784805

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

In this study, the investigators propose Pulsed Low-Intensity Focused Ultrasound (PLIFU) stimulation of brain regions that modulate (thalamus) or generate focal motor seizures (primary motor cortex), with the goal of ameliorating seizure activity in subjects in non-convulsive or focal motor status epilepticus. The course of treatment will consist of an initial 10 minute PLIFU treatment session with an option for a 2nd session if necessary. The primary objective of this study is to determine whether PLIFU reduces or suppresses epileptic activity in patients with Non-Convulsive Status Epilepticus (NCSE)/Focal Motor Status Epilepticus (FMSE) that have not responded to standard of care.

Study identification

NCT ID: NCT05784805
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Yale University; Other
Enrollment: 10 participants

Conditions and interventions

Conditions

Seizures

Interventions

PLIFU Device

Device

Eligibility (public fields only)

Age range: 19 Years to 85 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 24, 2023 (Actual)
Primary completion: Dec 2026 (Estimated)
Completion: Dec 2026 (Estimated)
Last update posted: Sep 21, 2026

2023 – 2026

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Yale New Haven Hospital	New Haven	Connecticut	06520	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05784805, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 21, 2026 · Synced Nov 15, 2026