A Study of Treatment of Inflammation Before Stem Cell Transplant in People With a Primary Immune Regulatory Disorder (PIRD) and/or an Autoinflammatory Condition

ClinicalTrials.gov ID: NCT05787574

Public ClinicalTrials.gov record NCT05787574. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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Official title

Phase 2 Study Bridging Pre-Transplant Inflammatory Dampening for Primary Immune Regulatory Disorders (BRIDGE Trial)

Study identification

NCT ID: NCT05787574
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: Joseph Oved; Other
Enrollment: 39 participants

Conditions and interventions

Conditions

Interventions

Emapalumab Drug
Fludarabine and Dexamethasone Drug
Allogeneic hematopoietic stem cell transplant (allo-HCT) Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: Not listed
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 14, 2023
Primary completion: Feb 28, 2027
Completion: Feb 28, 2027
Last update posted: Jun 1, 2026

2023 – 2027

United States locations

U.S. sites: 13
U.S. states: 7
U.S. cities: 12

Facility	City	State	ZIP	Site status
University of California, San Francisco	San Francisco	California	94143	Recruiting
Children's Healthcare of Atlanta	Atlanta	Georgia	30322	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Active, not recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Active, not recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Active, not recruiting
Memorial Sloan Kettering Suffolk - Commack	Commack	New York	11725	Active, not recruiting
Memorial Sloan Kettering Westchester	Harrison	New York	10604	Active, not recruiting
Columbia University Irving Medical Center	New York	New York	10032	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Active, not recruiting
Memorial Sloan Kettering Nassau	Rockville Centre	New York	11553	Active, not recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Texas Children's Hospital	Houston	Texas	77030	Recruiting
Children's Hospital of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05787574, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 1, 2026 · Synced Jul 22, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05787574 live on ClinicalTrials.gov.

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