A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
Public ClinicalTrials.gov record NCT05795699. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Masked, Randomized, Placebo-Controlled, Parallel-Group, 12-Week Administration With Two-Week Gradual Dose Taper Phase and 38-Week Follow-Up Phase, Phase 3 Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Descemetorhexis in Subjects With Fuchs Endothelial Corneal Dystrophy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A study to assess the safety and efficacy of K-321 in participants with FECD after descemetorhexis.
Study identification
- NCT ID
- NCT05795699
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 107 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 30, 2023 (Actual)
- Primary completion
- May 22, 2025 (Actual)
- Completion
- Feb 20, 2026 (Actual)
- Last update posted
- May 27, 2026
2023 – 2026
United States locations
- U.S. sites
- 26
- U.S. states
- 15
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| Macy Eye Center | Los Angeles | California | 90048 | — |
| Jules Stein Eye Institute | Los Angeles | California | 90095 | — |
| Byers Eye Institute at Stanford | Palo Alto | California | 94303 | — |
| Sacramento Eye Consultants | Sacramento | California | 95815 | — |
| Gorovoy MD Eye Specialists | Fort Myers | Florida | 33907 | — |
| University of Florida | Gainesville | Florida | 32605 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33418 | — |
| Bascom Palmer Eye Institute - Naples | Naples | Florida | 34103 | — |
| Eye Consultants of Atlanta | Atlanta | Georgia | 30339-5971 | — |
| Grene Vision Group | Wichita | Kansas | 67208-3648 | — |
| University of Kentucky | Lexington | Kentucky | 40508 | — |
| Massachusetts Eye and Ear Infirmary | Boston | Massachusetts | 02114 | — |
| W Kellogg Eye Center | Ann Arbor | Michigan | 48105 | — |
| Verdier Eye Center | Grand Rapids | Michigan | 49546 | — |
| Vance Thompson Vision - Omaha | Omaha | Nebraska | 68137 | — |
| Eye Associates of New Mexico | Albuquerque | New Mexico | 87109 | — |
| NYU Langone Health | New York | New York | 10017 | — |
| Vance Thompson Vision West Fargo | West Fargo | North Dakota | 58078 | — |
| University Hospitals Cleveland Medical Center - 11100 Euclid Ave | Cleveland | Ohio | 44106 | — |
| Devers Eye Institute | Portland | Oregon | 97210 | — |
| Casey Eye Institute - OHSU | Portland | Oregon | 97239 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Eye Associates | Houston | Texas | 77025 | — |
| R and R Eye Research, LLC. | San Antonio | Texas | 78229 | — |
| University of Wisconsin - 2870 University Ave | Madison | Wisconsin | 53705 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 24 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05795699, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 27, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05795699 live on ClinicalTrials.gov.