ClinicalTrials.gov record
A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19
ClinicalTrials.gov ID: NCT05815498
Public ClinicalTrials.gov record NCT05815498. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
All trial information on this site comes from the official ClinicalTrials.gov public API (clinicaltrials.gov/api/v2), run by the U.S. National Library of Medicine. We only display that public information; we do not add opinions, endorsements, or any other intent. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Observer-Blind, Active-Controlled Phase 3 Study to Investigate the Safety, Immunogenicity, and Relative Vaccine Efficacy of mRNA-1283 Compared With mRNA-1273 in Participants Aged ≥12 Years for the Prevention of COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).
Study identification
- NCT ID
- NCT05815498
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 13,553 participants
Conditions and interventions
Conditions
Interventions
- mRNA-1283.222 Biological
- mRNA-1273.222 Biological
- mRNA-1283.815 Biological
- mRNA-1273.815 Biological
Biological
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 28, 2023 (Actual)
- Primary completion
- Apr 12, 2025 (Actual)
- Completion
- Apr 12, 2025 (Actual)
- Last update posted
- May 1, 2026
2023 – 2025
United States locations
- U.S. sites
- 161
- U.S. states
- 35
- U.S. cities
- 132
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Optimal Research | Huntsville | Alabama | 35802 | — |
| Accel Research Sites- Achieve Clinical Research | Vestavia Hills | Alabama | 35216 | — |
| Chandler Clinical Trials | Chandler | Arizona | 85224 | — |
| Phoenix Clinical Research LLC | Phoenix | Arizona | 85014 | — |
| FRC - CCT Research | Phoenix | Arizona | 85244 | — |
| Headlands Research Sarasota | Scottsdale | Arizona | 85260 | — |
| Clinical Research Consortium | Tempe | Arizona | 85281 | — |
| Noble Clinical Research, LLC | Tucson | Arizona | 85704 | — |
| Del Sol research Management LLC. | Tucson | Arizona | 85715 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | — |
| Anaheim Clinical Trials, LLC | Anaheim | California | 92801 | — |
| Velocity Clinical Research, Banning | Banning | California | 92220 | — |
| Velocity Clinical Research- Chula Vista | Chula Vista | California | 91911 | — |
| Benchmark Research | Colton | California | 92324 | — |
| Marvel Clinical Research 002, LLC | Huntington Beach | California | 92647 | — |
| Velocity Clinical Research Huntington Park | Huntington Park | California | 90255 | — |
| Velocity Clinical Research | La Mesa | California | 91942 | — |
| Chemidox Clinical Trials | Lancaster | California | 93534 | — |
| Long Beach Clinical Trials | Long Beach | California | 90806 | — |
| Velocity Clinical Research- Westlake | Los Angeles | California | 90057 | — |
| Velocity Clinical Research-North Hollywood | North Hollywood | California | 90036 | — |
| Empire Clinical Research | Pomona | California | 91786 | — |
| CenExel - CITrials | Riverside | California | 82506 | — |
| Artemis Institute for Clinical Research | Riverside | California | 92503 | — |
| Peninsula Research Associates | Rolling Hills Estates | California | 90274 | — |
| Benchmark Research | Sacramento | California | 95864 | — |
| Artemis Institute for Clinical Research | San Diego | California | 92103 | — |
| Acclaim Clinical Research | San Diego | California | 92120 | — |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | — |
| Velocity Clinical Research Denver | Denver | Colorado | 80209 | — |
| Tekton Research - Fort Collins | Fort Collins | Colorado | 80525 | — |
| Tekton Research, Inc- Longmont Center | Longmont | Colorado | 80501 | — |
| Alliance for Multispeciality Research - Miami | Coral Gables | Florida | 33134 | — |
| Nature Coast Clinical Research | Crystal River | Florida | 34429 | — |
| Beautiful Minds Clinical Research Center | Cutler Bay | Florida | 33157 | — |
| Clinical Research Partners LLC | DeLand | Florida | 32720 | — |
| Hillcrest Medical Research, LLC | DeLand | Florida | 32720 | — |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | — |
| Sweet Hope Research Specialty, Inc. | Hialeah | Florida | 33016 | — |
| CenExel Research Centers of America | Hollywood | Florida | 33024 | — |
| Nature Coast Clinical Research | Inverness | Florida | 34452 | — |
| Encore Research Group-Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Clinical Neuroscience Solutions, Inc | Jacksonville | Florida | 32256 | — |
| Health Awareness INC | Jupiter | Florida | 33458 | — |
| Accel Clinical Research | Lakeland | Florida | 33803 | — |
| Accel Research Sites | Largo | Florida | 33709 | — |
| Acclaim Clinical Research | Maitland | Florida | 32751 | — |
| Suncoast Research Group, LLC | Miami | Florida | 33135 | — |
| Clinical Trials of Florida | Miami | Florida | 33186 | — |
| Suncoast Research Associates, LLC | Miami | Florida | 33713 | — |
| Floridian Clinical Research | Miami Lakes | Florida | 33016 | — |
| Global Health Research Center, Inc. | Miami Lakes | Florida | 33016 | — |
| Clinical Neuroscience Solutions (CNS Healthcare site) | Orlando | Florida | 32801 | — |
| Headlands Research Orlando | Orlando | Florida | 32819 | — |
| Innovation Medical Research Center | Palmetto Bay | Florida | 33157 | — |
| Pines Care Research Center, Inc. | Pembroke Pines | Florida | 33024 | — |
| Suncoast Research Associates, LLC | Pembroke Pines | Florida | 33324 | — |
| Synexus | Pinellas Park | Florida | 33781 | — |
| Precision Clinical Research | Sunrise | Florida | 33351 | — |
| Global Health Research Center, Inc. | Tampa | Florida | 33615 | — |
| Santos Research Center CORP | Tampa | Florida | 33615 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| Delricht Research | Atlanta | Georgia | 30329 | — |
| Atlanta Clinical Research Center | Atlanta | Georgia | 30342 | — |
| Baybol Research Institute | Chamblee | Georgia | 30341 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| Elite Research Network | Decatur | Georgia | 30030 | — |
| Accel Research Sites Lake Oconee | Eatonton | Georgia | 31024 | — |
| Georgia Clinic, PC/CCT Research | Norcross | Georgia | 30092 | — |
| Clinical Research Atlanta/Headlands | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research | Meridian | Idaho | 83642 | — |
| Chicago Clinical Research Institute | Chicago | Illinois | 60607 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Velocity Clinical Research Valparaiso | Valparaiso | Indiana | 46383 | — |
| Alliance for Multispecialty Research, LLC | El Dorado | Kansas | 67042 | — |
| Johnson County Clin-Trials, Inc (JCCT) | Lenexa | Kansas | 66219 | — |
| Alliance for Multispecialty Research, LLC- Wichita | Wichita | Kansas | 67207 | — |
| Tekton Research Inc | Wichita | Kansas | 67218 | — |
| Alliance for Multispecialty Research-Lexington | Lexington | Kentucky | 40509 | — |
| Versailles Family Medicine | Versailles | Kentucky | 40383 | — |
| Meridian Clinical Research | Baton Rouge | Louisiana | 70809 | — |
| Benchmark Research | Covington | Louisiana | 70006 | — |
| MedPharmics | Covington | Louisiana | 70433 | — |
| Benchmark Research | Metairie | Louisiana | 70006 | — |
| Delricht Research | New Orleans | Louisiana | 70115 | — |
| Delricht Clinical Research | Prairieville | Louisiana | 70769 | — |
| Centennial Medical Group | Eldridge | Maryland | 21075 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| DM Clinical Research | Brookline | Massachusetts | 02445 | — |
| Great Lakes Research Institute | Southfield | Michigan | 48075 | — |
| Clinical Research Institute | Minneapolis | Minnesota | 55402 | — |
| Delricht Research | Gulfport | Mississippi | 39503 | — |
| The Center for Pharmaceutical Research | Kansas City | Missouri | 64114 | — |
| Delricht Research | Springfield | Missouri | 65807 | — |
| Sundance Clinical Research, LLC | St Louis | Missouri | 63141 | — |
| Delricht Research | Town and Country | Missouri | 63017 | — |
| Montana Medical Research, Inc | Missoula | Montana | 59808 | — |
| CCT research/ Methodist Physicians Clinic- Prairie Fields | Fremont | Nebraska | 68025 | — |
| Velocity Clinical Research | Grand Island | Nebraska | 68803 | — |
| Meridian Clinical Research, LLC | Lincoln | Nebraska | 68510 | — |
| Velocity Clinical Research | Omaha | Nebraska | 68134 | — |
| Papillon Research Centre | Papillion | Nebraska | 68046 | — |
| Wr-Crcn, Llc | Las Vegas | Nevada | 89113 | — |
| Las Vegas Clinical Trials | North Las Vegas | Nevada | 89030 | — |
| IMA Clinical Research | Warren Township | New Jersey | 07059 | — |
| Velocity Clinical Research- New Mexico | Albuquerque | New Mexico | 87102 | — |
| IMA Clinical Research | Albuquerque | New Mexico | 87109 | — |
| Velocity Clinical Research, Syracuse | East Syracuse | New York | 13057 | — |
| IMA Clinical Research | New York | New York | 10036 | — |
| Rochester Clinical Research, Inc. | Rochester | New York | 14609 | — |
| Monroe Biomedical Research | Monroe | North Carolina | 28112 | — |
| Trial Management Associates, LLC | Wilmington | North Carolina | 28403 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Velocity Clinical Research, Inc | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45242 | — |
| Velocity Clinical Research - Cincinnati | Cincinnati | Ohio | 45246 | — |
| Velocity Clinical Research | Cleveland | Ohio | 44122 | — |
| Tekton Research- Edmond | Edmond | Oklahoma | 73013 | — |
| Tekton Research Inc | Moore | Oklahoma | 73160 | — |
| Delricht Research | Tulsa | Oklahoma | 74133 | — |
| Tekton Research- Yukon | Yukon | Oklahoma | 73099 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Summit Research Headlands LLC | Portland | Oregon | 97210 | — |
| DM Clinical Research | Philadelphia | Pennsylvania | 19107 | — |
| Synexus Clinical Research US, Inc | Anderson | South Carolina | 29621 | — |
| Velocity Clinical Research-Anderson | Anderson | South Carolina | 29621 | — |
| Delricht Research | Charleston | South Carolina | 29407 | — |
| Velocity Clinical Research | Columbia | South Carolina | 29204 | — |
| Velocity Clinical Research, Greenville | Greenville | South Carolina | 29615 | — |
| Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29464 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Velocity Clinical Research- Spartanburg | Spartanburg | South Carolina | 29303 | — |
| Delricht Research | Hendersonville | Tennessee | 37075 | — |
| Clinical Research Associates, Inc. | Nashville | Tennessee | 37203 | — |
| Benchmark Research | Austin | Texas | 78705 | — |
| Tekton Research Inc | Austin | Texas | 78745 | — |
| Tekton Research - Beaumont | Beaumont | Texas | 77706 | — |
| PanAmerican Clinical Research, LLC | Brownsville | Texas | 78520 | — |
| Headlands Research Brownsville | Brownsville | Texas | 78526 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| Ventavia Research Group | Fort Worth | Texas | 76104 | — |
| Benchmark Research | Fort Worth | Texas | 76135 | — |
| DM Clinical Research | Houston | Texas | 77065 | — |
| DM Clinical Research | Houston | Texas | 77081 | — |
| Ventavia Research Group | Keller | Texas | 76248 | — |
| DELRICHT RESEARCH at ZOMNIR FAMILY MEDICINE | McKinney | Texas | 75072 | — |
| Research Your Health | Plano | Texas | 75093 | — |
| Be Well Clinical Studies | Round Rock | Texas | 78681 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Diagnostics Research Group | San Antonio | Texas | 78229 | — |
| Tekton Research -San Antonio | San Antonio | Texas | 78240 | — |
| DM Clinical Research | Sugar Land | Texas | 77478 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Cope Family Medicine | Bountiful | Utah | 84010 | — |
| Mountain View Ogden Clinic/CCT Research | Pleasant View | Utah | 84404 | — |
| JBR Clinical Research | Salt Lake City | Utah | 84107 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic South | Salt Lake City | Utah | 84121 | — |
| Health Research of Hampton Roads, Inc. | Newport News | Virginia | 23606 | — |
| Velocity Clinical Research | Portsmouth | Virginia | 23703 | — |
| Clinical Research Partners, LLC | Richmond | Virginia | 23226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 69 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05815498, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 1, 2026 · Synced Nov 9, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05815498 live on ClinicalTrials.gov.