A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma

ClinicalTrials.gov ID: NCT05827016

Public ClinicalTrials.gov record NCT05827016. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 11, 2026, 2:41 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Two-stage, Randomized, Multi-center, Controlled, Open-label Study Comparing Iberdomide Maintenance to Lenalidomide Maintenance Therapy After Autologous Stem Cell Transplantation (ASCT) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) (EXCALIBER-Maintenance)

Study identification

NCT ID: NCT05827016
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Bristol-Myers Squibb; Industry
Enrollment: 1,216 participants

Conditions and interventions

Conditions

Multiple Myeloma

Interventions

Iberdomide Drug
Lenalidomide Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 21, 2023
Primary completion: Mar 14, 2029
Completion: Dec 31, 2035
Last update posted: Mar 12, 2026

2023 – 2036

United States locations

U.S. sites: 44
U.S. states: 18
U.S. cities: 37

Facility	City	State	ZIP	Site status
Rocky Mountain Cancer Centers	Aurora	Colorado	80012-5405	Recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Recruiting
Tampa General Hospital	Tampa	Florida	33606	Recruiting
H. Lee Moffitt Cancer Center & Research Institute	Tampa	Florida	33612-9416	Recruiting
Cleveland Clinic	Weston	Florida	33331-3609	Recruiting
University Cancer Blood Ctr	Athens	Georgia	30607-1465	Recruiting
The Winship Cancer Institute of Emory University	Atlanta	Georgia	30322-1013	Recruiting
Augusta University - Georgia Cancer Center	Augusta	Georgia	30912	Recruiting
The University of Chicago Medical Center - Duchossois Center for Advanced Medicine	Chicago	Illinois	60637-1426	Recruiting
University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion	Westwood	Kansas	66205-2003	Recruiting
Maryland Oncology Hematology, PA- Clinton	Clinton	Maryland	20735-4230	Recruiting
UMass Memorial Medical Center	Worcester	Massachusetts	01655	Recruiting
University of Michigan - Rogel Cancer Center	Ann Arbor	Michigan	48109-5000	Recruiting
Henry Ford Health System - The Henry Ford Cancer Institute (HFCI) - Detroit	Detroit	Michigan	48202-2610	Recruiting
Cancer & Hematology Centers of Western Michigan (CHCWM)	Grand Rapids	Michigan	49503	Recruiting
Mayo Clinic Cancer Center (MCCC) - Rochester	Rochester	Minnesota	55905	Recruiting
Hattiesburg Clinic - Hematology & Oncology	Hattiesburg	Mississippi	39401	Recruiting
Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Local Institution - 0328	Brooklyn	New York	11220-3313	Not yet recruiting
Perlmutter Cancer Center at NYU Langone Hematology Oncology Associates-Mineola	Mineola	New York	11501	Recruiting
NYU Langone Health	New York	New York	10016-6402	Recruiting
Columbia University Medical Center - Herbert Irving Pavilion Location	New York	New York	10032-3729	Recruiting
Clinical Research Alliance	Westbury	New York	11590	Recruiting
Levine Cancer Institute	Charlotte	North Carolina	28204	Recruiting
Novant Health Cancer Institute - Elizabeth	Charlotte	North Carolina	28803-2493	Recruiting
Duke University Hospital	Durham	North Carolina	27705-3976	Recruiting
Novant Health Cancer Institute Hematology - Forsyth	Winston-Salem	North Carolina	27103	Recruiting
Wake Forest University Baptist Medical Center (WFUBMC) - Comprehensive Cancer Center	Winston-Salem	North Carolina	27157	Recruiting
Oncology Hematology Care, Inc. - Cincinnati - Galbraith Rd	Cincinnati	Ohio	45236-2725	Recruiting
Cleveland Clinic - Fairview Hospital - Cancer Center (Moll Cancer Center)	Cleveland	Ohio	44111	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Midwest Oncology Associates - Kansas City	Kansas	Ohio	64132	Recruiting
Cleveland Clinic - Hillcrest Hospital - Hillcrest Cancer Center	Mayfield Heights	Ohio	44124	Recruiting
Local Institution - 0013	Toledo	Ohio	43623	Completed
Wooster Milltown Specialty and Surgery Center	Wooster	Ohio	44691	Recruiting
Willamette Valley Cancer Institute	Eugene	Oregon	97401	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center - Jeanes Campus	Philadelphia	Pennsylvania	19111-2433	Recruiting
University of Pittsburgh - Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
West Cancer Center	Germantown	Tennessee	38138-1762	Recruiting
Tennessee Oncology	Nashville	Tennessee	37203-1625	Recruiting
Texas Oncology - Baylor Charles A. Sammons Cancer Center	Dallas	Texas	75246	Recruiting
UT Southwestern-Harold C. Simmons Cancer Center	Dallas	Texas	75390-0001	Recruiting
University of Texas MD Anderson Cancer Center	Houston	Texas	77030-4000	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 241 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05827016, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 12, 2026 · Synced May 11, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05827016 live on ClinicalTrials.gov.

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