Independent directory Public ClinicalTrials.gov records United States
Clinical Trials Finder
Objective public record navigation
ClinicalTrials.gov record
Recruiting Phase 3 Interventional

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

ClinicalTrials.gov ID: NCT05827081

Public ClinicalTrials.gov record NCT05827081. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search
ClinicalTrials.gov public records Last synced Oct 19, 2026, 10:00 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase IIIb Study to Characterize the Efficacy and Safety of Adjuvant Ribociclib Plus Endocrine Therapy in a Close-to-clinical Practice Patient Population With HR+ HER2- Early Breast Cancer (Adjuvant WIDER)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this open-label, multicenter, phase IIIb, single-arm study is to characterize the efficacy and safety of the combination of ribociclib and standard adjuvant endocrine therapy (ET) on invasive breast cancer-free survival (iBCFS), in a close to clinical practice patient population with HR-positive (HR+), HER2-negative (HER2-), Anatomic Stage Group III, IIB, and a subset of Stage IIA Early Breast Cancer (EBC).

Study identification

NCT ID
NCT05827081
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
1,444 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years to 100 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 28, 2024 (Actual)
Primary completion
Sep 7, 2029 (Estimated)
Completion
Sep 20, 2030 (Estimated)
Last update posted
Oct 19, 2026

2024 – 2030

United States locations

U.S. sites
85
U.S. states
38
U.S. cities
77
Facility City State ZIP Site status
Central Alabama Research Birmingham Alabama 35209 Recruiting
Alaska Oncology and Hematology LLC Anchorage Alaska 99508 Recruiting
Western Reg MC-COH Phoenix Goodyear Arizona 85338 Active, not recruiting
CARTI Cancer Center Little Rock Arkansas 72205 Active, not recruiting
Beverly Hills Cancer Center Beverly Hills California 90211 Active, not recruiting
Onco Inst of Hope and Innovation Cerritos California 90703 Recruiting
City of Hope National Medical Duarte California 91010 Recruiting
Providence Medical Foundation Fullerton California 92835 Recruiting
Los Angeles Cancer Network Good Samaritan Los Angeles California 90017 Recruiting
El Camino Hospital Mountain View California 94040 Recruiting
Palo Alto Medical Foundation Mountain View California 94040 Recruiting
UC Irvine Medical Center Orange California 92868 Active, not recruiting
Sutter Inst Medical Research Sacramento California 95816-5199 Active, not recruiting
School Of Medicine Sacramento California 95817 Active, not recruiting
Sharp Rees Stealy Medical Group Inc San Diego California 92101 Recruiting
AdventHealth Medical Group Hematology and Oncology Denver Colorado 80210 Withdrawn
Rocky Mountain Cancer Centers Denver Colorado 80218 Active, not recruiting
Georgetown University Lombardi Cancer Center Washington D.C. District of Columbia 20007-2197 Active, not recruiting
Medstar Washington Hospital Center Washington D.C. District of Columbia 20010 Active, not recruiting
AdventHealth Altamonte Springs Altamonte Springs Florida 32701 Active, not recruiting
Holy Cross Health Fort Lauderdale Florida 33308 Active, not recruiting
Hialeah Hospital Hialeah Florida 33013 Active, not recruiting
Memorial Cancer Institute Hollywood Florida 33021 Recruiting
Jupiter Medical Center Jupiter Florida 33458 Recruiting
Ocala Research Institute Inc Ocala Florida 34474 Active, not recruiting
University Cancer and Blood Center LLC Athens Georgia 30607 Withdrawn
Summit Cancer Care PC Savannah Georgia 31405 Active, not recruiting
Hawaii Cancer Care Honolulu Hawaii 96813 Withdrawn
Affiliated Oncologists IL Chicago Illinois 60415 Active, not recruiting
Hope And Healing Care Hinsdale Illinois 60521 Recruiting
Midwestern Reg MC COH Chicago Zion Illinois 60099 Active, not recruiting
Investigative Clinical R of Indiana Indianapolis Indiana 46260 Recruiting
University of Iowa Health Care Waukee Iowa 50263 Active, not recruiting
University of Kansas Cancer Center Westwood Kansas 66205 Active, not recruiting
Cancer Center of Kansas Wichita Kansas 67214-3728 Active, not recruiting
Willis-Knighton Cancer Center Shreveport Louisiana 71103 Active, not recruiting
Mercy Medical Center Baltimore Maryland 21202 Recruiting
Maryland Oncology Hematology P A Silver Spring Maryland 20904 Recruiting
Boston Medical Center Boston Massachusetts 02215 Active, not recruiting
Dana Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Dana Farber Brigham Women Cancer Milford Massachusetts 01757 Withdrawn
Minnesota Oncology Hematology P A Minneapolis Minnesota 55404 Active, not recruiting
Allina Hlth Cancer Inst Minneapolis Minneapolis Minnesota 55407 Recruiting
Jackson Oncology Associates Jackson Mississippi 39202 Recruiting
HCA Midwest Division Kansas City Missouri 64132 Active, not recruiting
WA Uni School Of Med St Louis Missouri 63110 Active, not recruiting
Intermountain Healthcare Billings Montana 59102 Active, not recruiting
Nebraska Cancer Specialists Omaha Nebraska 68154 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Active, not recruiting
Cancer Care Specialists Reno Nevada 89511 Active, not recruiting
MD Anderson Cancer Center At Cooper Camden New Jersey 08103 Active, not recruiting
Summit Health Florham Park New Jersey 07932 Active, not recruiting
The Valley Hospital Ridgewood New Jersey 07450 Active, not recruiting
Presbyterian Medical Group Albuquerque New Mexico 87110 Active, not recruiting
Queens Cancer Center of Queens Hospital Jamaica New York 11432 Active, not recruiting
Optum Health Lake Success New York 11042 Active, not recruiting
Mount Sinai School of Medicine New York New York 10029 Recruiting
Duke Cancer Network Durham North Carolina 27710 Recruiting
Cone Health Cancer Center Greensboro North Carolina 27403 Recruiting
Sanford Research USD Fargo Fargo North Dakota 58122 Active, not recruiting
Good Samaritan Regional Medical Center Corvallis Oregon 97330 Active, not recruiting
Oncology Associates of Oregon PC Eugene Oregon 97401-8122 Recruiting
Northwest Cancer Specialists Portland Oregon 97210 Recruiting
Oregon Oncology Specialists Salem Salem Oregon 97301 Recruiting
Consultants In Med Onco And Hema Drexel Hill Pennsylvania 19026 Active, not recruiting
Univ of Pittsburg Med Ctr Pinnacle Harrisburg Pennsylvania 17109 Active, not recruiting
Allegheny Health Network Pittsburgh Pennsylvania 15212 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Active, not recruiting
Bon Secours St Francis Cancer Center Greenville South Carolina 29607 Recruiting
Lexington Medical Center West Columbia South Carolina 29169 Withdrawn
Regional Medical Oncology NC Wilson South Carolina 27893 Withdrawn
Sanford USD Medical Center Sioux Falls South Dakota 57104 Active, not recruiting
Sarah Cannon Research Institute Nashville Tennessee 37203 Recruiting
El Paso Texas Oncology El Paso Texas 79902 Active, not recruiting
Kelsey Seybold Clinic Houston Texas 77025 Active, not recruiting
University of Texas Houston Texas 77030-4099 Recruiting
Texas Oncology P A Plano East Plano Texas 75075 Active, not recruiting
Texas Oncology PA Tyler Tyler Texas 75702 Active, not recruiting
Bon Secours Virginia Health System Midlothian Virginia 23114 Recruiting
Virginia Oncology Associates Norfolk Virginia 23502 Active, not recruiting
Kadlec Clinic Hematology and Onco Kennewick Washington 99336 Active, not recruiting
Providence Regional Cancer System Lacey Washington 98503 Active, not recruiting
Valley Medical Center Research Renton Washington 98055 Active, not recruiting
Northwest Medical Specialties Tacoma Washington 98405 Active, not recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 144 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05827081, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 19, 2026 · Synced Oct 19, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05827081 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →