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Recruiting Phase 3 Interventional

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

ClinicalTrials.gov ID: NCT05827081

Public ClinicalTrials.gov record NCT05827081. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase IIIb Study to Characterize the Efficacy and Safety of Adjuvant Ribociclib Plus Endocrine Therapy in a Close-to-clinical Practice Patient Population With HR+ HER2- Early Breast Cancer (Adjuvant WIDER)

Study identification

NCT ID
NCT05827081
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Novartis Pharmaceuticals
Industry
Enrollment
1,400 participants

Conditions and interventions

Interventions

  • Ansastrozole Drug
  • Exemestane Drug
  • Goserelin Drug
  • Letrozole Drug
  • Leuprolide Drug
  • Ribociclib Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 100 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Feb 27, 2024
Primary completion
Sep 6, 2029
Completion
Sep 19, 2030
Last update posted
May 7, 2026

2024 – 2030

United States locations

U.S. sites
72
U.S. states
36
U.S. cities
67
Facility City State ZIP Site status
Central Alabama Research Birmingham Alabama 35209 Recruiting
Alaska Oncology and Hematology LLC Anchorage Alaska 99508 Recruiting
Western Reg MC-COH Phoenix Goodyear Arizona 85338 Recruiting
CARTI Cancer Center Little Rock Arkansas 72205 Recruiting
Beverly Hills Cancer Center Beverly Hills California 90211 Recruiting
Onco Inst of Hope and Innovation Cerritos California 90703 Recruiting
City of Hope National Medical Duarte California 91010 Recruiting
Providence Medical Foundation Fullerton California 92835 Recruiting
Palo Alto Medical Foundation Mountain View California 94040 Recruiting
UC Irvine Medical Center Orange California 92868 Recruiting
Sutter Inst Medical Research Sacramento California 95816-5199 Recruiting
School Of Medicine Sacramento California 95817 Recruiting
Rocky Mountain Cancer Centers Denver Colorado 80218 Recruiting
Georgetown University Lombardi Cancer Center Washington D.C. District of Columbia 20007-2197 Recruiting
Washington Hospital Center Washington D.C. District of Columbia 20010 Recruiting
Holy Cross Health Fort Lauderdale Florida 33308 Recruiting
Hialeah Hospital Hialeah Florida 33013 Recruiting
Memorial Cancer Institute Hollywood Florida 33021 Recruiting
Ocala Research Institute, Inc Ocala Florida 34474 Recruiting
Summit Cancer Care PC Savannah Georgia 31405 Recruiting
Hawaii Cancer Care Honolulu Hawaii 96813 Recruiting
Affiliated Oncologists IL Chicago Illinois 60415 Recruiting
Hope And Healing Care Hinsdale Illinois 60521 Recruiting
Midwestern Reg MC COH Chicago Zion Illinois 60099 Recruiting
Investigative Clinical R of Indiana Indianapolis Indiana 46260 Recruiting
University of Iowa Health Care Waukee Iowa 50263 Recruiting
University of Kansas Cancer Center Westwood Kansas 66205 Recruiting
Cancer Center of Kansas Wichita Kansas 67214-3728 Recruiting
Willis-Knighton Cancer Center Shreveport Louisiana 71103 Recruiting
Mercy Medical Center Baltimore Maryland 21202 Recruiting
Maryland Oncology Hematology P A Silver Spring Maryland 20904 Recruiting
Boston Medical Center Boston Massachusetts 02118 Recruiting
Dana Farber Cancer Institute Boston Massachusetts 02215 Recruiting
Dana Farber Brigham Women Cancer Milford Massachusetts 01757 Recruiting
Minnesota Oncology Hematology P A Minneapolis Minnesota 55404 Recruiting
Jackson Oncology Associates Jackson Mississippi 39202 Recruiting
HCA Midwest Division Kansas City Missouri 64132 Recruiting
WA Uni School Of Med St Louis Missouri 63110 Recruiting
Intermountain Healthcare Billings Montana 59102 Recruiting
Nebraska Cancer Specialists Omaha Nebraska 68154 Recruiting
Renown Regional Medical Center Reno Nevada 89502 Recruiting
Cancer Care Specialists Reno Nevada 89511 Recruiting
Summit Health Florham Park New Jersey 07932 Recruiting
The Valley Hospital Ridgewood New Jersey 07450 Recruiting
Presbyterian Medical Group Albuquerque New Mexico 87110 Recruiting
Queens Cancer Center of Queens Hospital Jamaica New York 11432 Recruiting
Optum Health Lake Success New York 11042 Recruiting
Mount Sinai School of Medicine New York New York 10029 Recruiting
Duke Cancer Network Durham North Carolina 27710 Recruiting
Cone Health Cancer Center Greensboro North Carolina 27403 Recruiting
Oncology Associates of Oregon PC Eugene Oregon 97401-8122 Recruiting
Northwest Cancer Specialists Portland Oregon 97210 Recruiting
Oregon Oncology Specialists Salem Salem Oregon 97301 Recruiting
Consultants In Med Onco And Hema Drexel Hill Pennsylvania 19026 Recruiting
Univ of Pittsburg Med Ctr Pinnacle Harrisburg Pennsylvania 17109 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Bon Secours St Francis Cancer Center Greenville South Carolina 29607 Recruiting
Lexington Medical Center West Columbia South Carolina 29169 Recruiting
Regional Medical Oncology NC Wilson South Carolina 27893 Recruiting
Sanford USD Medical Center Sioux Falls South Dakota 57104 Recruiting
Sarah Cannon Research Institute Nashville Tennessee 37203 Recruiting
El Paso Texas Oncology El Paso Texas 79902 Recruiting
Kelsey Seybold Clinic Houston Texas 77025 Recruiting
University of Texas Houston Texas 77030-4099 Recruiting
Texas Oncology P A Plano East Plano Texas 75075 Recruiting
Texas Oncology PA Tyler Tyler Texas 75702 Recruiting
Bon Secours Virginia Health System Midlothian Virginia 23114 Recruiting
Virginia Oncology Associates Norfolk Virginia 23502 Recruiting
Kadlec Clinic Hematology and Onco Kennewick Washington 99336 Recruiting
Providence Regional Cancer System Lacey Washington 98503 Recruiting
Valley Medical Center Research Renton Washington 98055 Recruiting
Northwest Medical Specialties Tacoma Washington 98405 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 135 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05827081, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 7, 2026 · Synced May 10, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05827081 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →