A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults
Public ClinicalTrials.gov record NCT05827926. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, Randomized, Observer-blind, Active-Control Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-based Influenza and SARS-CoV-2 Multi-component Vaccines in Healthy Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study is divided into 2 parts: Part 1 and Part 2. The purpose of Part 1 of this study is to generate sufficient safety, reactogenicity, and immunogenicity data to enable selection of an mRNA-1083 vaccine composition and dose level to evaluate in a subsequent Phase 3 clinical trial in adults. The purpose of Part 2 of this study is to generate safety and immunogenicity data for additional mRNA-1083 compositions and dose levels in young adults ≥18 years and \<50 years of age.
Study identification
- NCT ID
- NCT05827926
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 1,758 participants
Conditions and interventions
Conditions
Interventions
- Influenza Vaccine 1 Biological
- mRNA-1083.1 Biological
- mRNA-1083.2 Biological
- mRNA-1083.3 Biological
- Investigational Influenza Vaccine 1 Biological
- Investigational COVID-19 Vaccine 1 Biological
- COVID-19 Vaccine 1 Biological
- Investigational Influenza Vaccine 2 Biological
- Influenza Vaccine 2 Biological
- mRNA-1083 Biological
- Investigational COVID-19 Vaccine 2 Biological
- COVID-19 Vaccine 2 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 14, 2023 (Actual)
- Primary completion
- Dec 3, 2024 (Actual)
- Completion
- Dec 3, 2024 (Actual)
- Last update posted
- Dec 23, 2025
2023 – 2024
United States locations
- U.S. sites
- 69
- U.S. states
- 27
- U.S. cities
- 62
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Chandler Clinical Trials | Chandler | Arizona | 85224-6231 | — |
| Benchmark Research | Colton | California | 92324 | — |
| Marvel Clinical Research | Huntington Beach | California | 92647-6835 | — |
| Central Valley Research | Modesto | California | 95350-5365 | — |
| Benchmark Research | Sacramento | California | 95864-3102 | — |
| Tekton Research | Longmont | Colorado | 80501-6461 | — |
| Accel Research Sites | DeLand | Florida | 32720-0834 | — |
| CenExel | Hollywood | Florida | 33024 | — |
| Nature Coast Clinical Research | Inverness | Florida | 34452 | — |
| Jacksonville Center For Clinical Research | Jacksonville | Florida | 32216 | — |
| Accel Research Sites | Maitland | Florida | 32751 | — |
| Suncoast Research Group | Miami | Florida | 33135-1687 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| Accel Research Site | Decatur | Georgia | 30030-2615 | — |
| CenExel iResearch | Decatur | Georgia | 30030 | — |
| Lifeline Primary Care | Lilburn | Georgia | 30047-2832 | — |
| Koch Family Medicine | Morton | Illinois | 61550 | — |
| Optimal Research | Peoria | Illinois | 61614-4885 | — |
| DM Clinical Research | River Forest | Illinois | 60305-1876 | — |
| Johnson County Clin-Trials | Lenexa | Kansas | 66219-1389 | — |
| Tekton Research | Wichita | Kansas | 67218-2913 | — |
| Versailles Family Medicine | Versailles | Kentucky | 40383-1947 | — |
| Velocity Clinical research | Baton Rouge | Louisiana | 70809 | — |
| Benchmark Research | Metairie | Louisiana | 70006 | — |
| DelRicht Research | New Orleans | Louisiana | 70115 | — |
| DelRicht Research | Prairieville | Louisiana | 70769 | — |
| Annapolis Internal Medicine | Annapolis | Maryland | 21401 | — |
| Velocity Clinical Research | Rockville | Maryland | 20854 | — |
| DM Clinical Research | Brookline | Massachusetts | 02445-7113 | — |
| Vida Clinical Studies | Dearborn Heights | Michigan | 48127-2234 | — |
| DelRicht Research | Gulfport | Mississippi | 39503 | — |
| Clay Platte Family Medicine | Kansas City | Missouri | 64151-2411 | — |
| Velocity Clinical Research | Lincoln | Nebraska | 68510 | — |
| Velocity Clinical Research | Norfolk | Nebraska | 68701 | — |
| Excel Clinical Research | Las Vegas | Nevada | 89109-6209 | — |
| CCT Research | Las Vegas | Nevada | 89119 | — |
| Las Vegas Clinical Trials | North Las Vegas | Nevada | 89030-7193 | — |
| Rochester Clinical Research | Rochester | New York | 14609-3169 | — |
| Tryon Medical Partners | Charlotte | North Carolina | 28210 | — |
| Trial Management Associates | Wilmington | North Carolina | 28403-6238 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45219 | — |
| Velocity Clinical Research | Cincinnati | Ohio | 45246 | — |
| Centricity Research | Columbus | Ohio | 43213 | — |
| WellNow Urgent Care & Research | Dayton | Ohio | 45424-4019 | — |
| Lynn Institute of East Oklahoma | Oklahoma City | Oklahoma | 73111-3324 | — |
| DelRicht Research | Tulsa | Oklahoma | 74133 | — |
| Tekton Research Inc | Yukon | Oklahoma | 73099-9518 | — |
| DM Clinical Research | Philadelphia | Pennsylvania | 19107-1530 | — |
| Mercado Medical Practice | Philadelphia | Pennsylvania | 19111-2432 | — |
| DelRicht Research | Charleston | South Carolina | 29407 | — |
| Trial Management Associates | Myrtle Beach | South Carolina | 29572-4612 | — |
| Medical Care | Elizabethton | Tennessee | 37643 | — |
| DelRicht Research | Hendersonville | Tennessee | 37075 | — |
| Benchmark Research | Austin | Texas | 78705-3298 | — |
| Tekton Research | Austin | Texas | 78745-1470 | — |
| Tekton Research | Beaumont | Texas | 77706-3061 | — |
| Benchmark Research | Fort Worth | Texas | 76135 | — |
| Cyfair Clinical Research | Houston | Texas | 77065 | — |
| Texas Center for Drug Development | Houston | Texas | 77081 | — |
| DelRicht Research | McKinney | Texas | 75070 | — |
| Benchmark Research | San Angelo | Texas | 76904-7610 | — |
| Tekton Research | San Antonio | Texas | 78229 | — |
| CCT Research | Pleasant View | Utah | 84404 | — |
| Ogden Clinic | Roy | Utah | 84067 | — |
| JBR Clinical Research | Salt Lake City | Utah | 84107 | — |
| Meridian Clinical Research | Hampton | Virginia | 23666 | — |
| Velocity Clinical Research | Portsmouth | Virginia | 23703 | — |
| Wenatchee Valley Hospital & Clinics Campus | Wenatchee | Washington | 98801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05827926, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 23, 2025 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05827926 live on ClinicalTrials.gov.