A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have
Public ClinicalTrials.gov record NCT05831176. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, 2-Part, Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD). Participants with EoD only are not eligible for enrollment. EoG and EoD are uncommon, persistent, allergic/immune diseases in which eosinophils (a type of white blood cell) gather in large numbers in the stomach and small intestine and cause inflammation and damage. The aim of the study is to evaluate the effect of dupilumab on relieving EoG (with or without EoD) symptoms and reducing inflammation in the stomach and, if applicable, small intestine in adults and adolescents aged 12 years and older after at least 24 weeks (about 6 months) and up to 52 weeks (1 year) of treatment. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Study identification
- NCT ID
- NCT05831176
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 22 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 3, 2023 (Actual)
- Primary completion
- Feb 23, 2026 (Actual)
- Completion
- Nov 25, 2026 (Estimated)
- Last update posted
- Jul 1, 2026
2023 – 2026
United States locations
- U.S. sites
- 36
- U.S. states
- 22
- U.S. cities
- 34
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Phoenix Childrens Hospital | Phoenix | Arizona | 85016 | — |
| Om Research LLC | Apple Valley | California | 92307 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| University of California - Los Angeles (UCLA) | Los Angeles | California | 90024 | — |
| University of Southern California Keck School of Medicine | Los Angeles | California | 90033 | — |
| GastroIntestinal BioSciences | Los Angeles | California | 90067 | — |
| United Medical Doctors | Murrieta | California | 92563 | — |
| Ucsf Medical Center (Benioff Childrens Hospital) | San Francisco | California | 94158 | — |
| University of Colorado Anschutz Health Science Building (AHSB) CU Research Pharmacy | Aurora | Colorado | 80045 | — |
| Connecticut Clinical Research Institute | Bristol | Connecticut | 06010 | — |
| UConn Health | Farmington | Connecticut | 06030 | — |
| Encore Borland-Groover Clinical Research | Jacksonville | Florida | 32256 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University Of Kansas | Kansas City | Kansas | 66103 | — |
| Beth Israel Deaconess Medical Center (BIDMC) Harvard Medical School | Boston | Massachusetts | 02215 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| MNGI Digestive Health P.A. | Plymouth | Minnesota | 55446 | — |
| Mayo Clinic Hospital Rochester | Rochester | Minnesota | 55905 | — |
| Advanced Research Institute | Reno | Nevada | 89511 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH) | New York | New York | 10029 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Charlotte Gastroenterology & Hepatology, PLLC | Charlotte | North Carolina | 28207 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| ESI Medical Research, PLLC | Kinston | North Carolina | 28513 | — |
| University of Cincinnati Medical Center-Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43210 | — |
| Allergy, Asthma and Clinical Research Center | Oklahoma City | Oklahoma | 73120 | — |
| The Oregon Clinic - Gastroenterology East | Portland | Oregon | 97220 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| TDDC dba GI Alliance Research | Mansfield | Texas | 76063 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Seattle Children's Home Health Company | Seattle | Washington | 98105 | — |
| Froedtert Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05831176, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 1, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05831176 live on ClinicalTrials.gov.