A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy
Public ClinicalTrials.gov record NCT05875974. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Open-Label, Single-Arm, Multicenter Study to Evaluate the Effect of Low-Sodium Oxybate Oral Solution (XYWAV) on Sleepiness, Polysomnography, and Functional Outcomes in Adult Participants Aged 18 to 75 Years With Idiopathic Hypersomnia or Narcolepsy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the safety and efficacy of JZP258 (XYWAV) on sleepiness, polysomnography, and functional outcomes in patients with idiopathic hypersomnia (IH) or narcolepsy.
Study identification
- NCT ID
- NCT05875974
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 199 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 27, 2023 (Actual)
- Primary completion
- Mar 13, 2025 (Actual)
- Completion
- Mar 13, 2025 (Actual)
- Last update posted
- Aug 27, 2026
2023 – 2025
United States locations
- U.S. sites
- 29
- U.S. states
- 13
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sleep Disorders Center of Alabama | Birmingham | Alabama | 35213 | — |
| Perseverance Research Center, LLC | Scottsdale | Arizona | 85253 | — |
| Amnova Clinical Research | Irvine | California | 92604 | — |
| Long Beach Research Institute | Lakewood | California | 90805 | — |
| Santa Monica Clinical Trials | Los Angeles | California | 90025 | — |
| Stanford School of Medicine | Redwood City | California | 94063 | — |
| TriValley Sleep Center | San Ramon | California | 94583 | — |
| SDS Clinical Trials, Inc. | Santa Ana | California | 92705 | — |
| Meris Clinical Research, LLC | Brandon | Florida | 33511 | — |
| PharmaDev Clinical Research Institute, LLC | Miami | Florida | 33176 | — |
| Florida Hospital for Children | Winter Park | Florida | 32789 | — |
| NeuroTrials Research, Inc. | Atlanta | Georgia | 30328 | — |
| Centricity Research Rincon - DBA IACT Health Southeast Lung Associates Research | Rincon | Georgia | 31326 | — |
| Neurocare, Inc., dba Neurocare Center for Research | Newtown | Massachusetts | 02459 | — |
| Clinical Neurophysiology Services, P.C. | Sterling Heights | Michigan | 48314 | — |
| St. Lukes Hospital Medical Center | Chesterfield | Missouri | 63017 | — |
| Clinical Research of Gastonia | Gastonia | North Carolina | 28054 | — |
| Stern Research Partners, LLC | Huntersville | North Carolina | 28078 | — |
| CTI Clinical Research Center | Cincinnati | Ohio | 45212 | — |
| Intrepid Research | Cincinnati | Ohio | 45245 | — |
| Cleveland Clinic Main Campus - Clinical Research Unit | Cleveland | Ohio | 44195 | — |
| Ohio Sleep Medicine and Neuroscience Institute | Dublin | Ohio | 43017 | — |
| Abington Neurological Associates, LTD | Abington | Pennsylvania | 19001 | — |
| Geisinger Clinic | Scranton | Pennsylvania | 18510 | — |
| Bogan Sleep Consultants, LLC | Columbia | South Carolina | 29201 | — |
| FutureSearch Trials of Neurology | Austin | Texas | 78731 | — |
| Comprehensive Sleep Medicine Associates | Houston | Texas | 77030 | — |
| Sleep Therapy & Research Center | San Antonio | Texas | 78229 | — |
| Tricoastal Narcolepsy and Sleep Disorders Center | Sugar Land | Texas | 77479 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05875974, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05875974 live on ClinicalTrials.gov.