Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors
Public ClinicalTrials.gov record NCT05887492. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of TNG260 as Single Agent and in Combination With an Anti-PD-1 Antibody In Patients With STK11 Mutated Advanced Solid Tumors
Study identification
- NCT ID
- NCT05887492
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Tango Therapeutics, Inc.
- Industry
- Enrollment
- 126 participants
Conditions and interventions
Interventions
- TNG260 Drug
- Pembrolizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 11, 2023
- Primary completion
- Dec 31, 2025
- Completion
- May 31, 2026
- Last update posted
- Nov 17, 2025
2023 – 2026
United States locations
- U.S. sites
- 13
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCLA Hematology/Oncology | Santa Monica | California | 90404 | Recruiting |
| SCRI at HealthOne | Denver | Colorado | 80218 | Recruiting |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Recruiting |
| START MidWest | Grand Rapids | Michigan | 49546 | Recruiting |
| NYU Langone Hematology Oncology Associates-Mineola | Mineola | New York | 11501 | Recruiting |
| New York University Langone Health | New York | New York | 10016 | Recruiting |
| Sarah Cannon Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| US Oncology Investigational Products Center | Dallas | Texas | 75246 | Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| NEXT Oncology Virginia | Fairfax | Virginia | 22031 | Recruiting |
| US Oncology Investigational Products Center | Norfolk | Virginia | 23502 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05887492, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 17, 2025 · Synced Jun 25, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05887492 live on ClinicalTrials.gov.