Study of the Efficacy and Safety of NST-1024 Versus Placebo in Subjects With Hypertriglyceridemia
Public ClinicalTrials.gov record NCT05889156. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Placebo-Controlled 28- Day Phase II Proof of Concept Study to Evaluate the Efficacy and Safety of NST-1024 400 mg BID Versus Placebo in Statin-Naïve or Statin-Stable Hypertriglyceridemic Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IIa,multicentre proof of concept study consisting of 2 study periods to study Treatment with NST-1024 as an adjunct to diet to reduce triglyceride (TG) levels in subjects with TG levels of ≥500 mg/dL and ≤2000 mg/dL; determined by percentage change in TG from baseline after 28 days of treatment. The two periods consist of: 1. A 3-week screening period that includes a TG qualifying period, and 2. A 28-days, double-blind, randomized, parallel group, placebo-controlled treatment period. Subjects will return to the study site for a follow-up visit 2 weeks after the last dose. Approximately 50 subjects will be randomized at approximately 15-35 centers in USA.
Study identification
- NCT ID
- NCT05889156
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 50 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 29, 2023
- Primary completion
- Mar 17, 2025
- Completion
- Apr 10, 2025
- Last update posted
- Apr 23, 2025
2023 – 2025
United States locations
- U.S. sites
- 31
- U.S. states
- 19
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama - Heersink School of Medicine | Birmingham | Alabama | 35487 | — |
| Alliance for Multispecialty Research, LLC (AMR) - Daphne | Daphne | Alabama | 36526 | — |
| Alliance for Multispecialty Research, LLC (AMR) - Phoenix | Tempe | Arizona | 85281 | — |
| Velocity Clinical Research, San Diego | La Mesa | California | 91942 | — |
| Velocity Clinical Research, North Hollywood | North Hollywood | California | 91605 | — |
| Velocity Clinical Research - Costal Heart | Santa Ana | California | 92704 | — |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | — |
| Velocity Clinical Research, New Smyrna Beach | Edgewater | Florida | 32132 | — |
| Clearwater Cardiovascular Consultants | Largo | Florida | 33756 | — |
| Floridian Clinical Research | Miami Lakes | Florida | 33014 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Lifeline Primary Care/ CCT Research | Lilburn | Georgia | 30047 | — |
| Velocity Clinical Research - Boise | Meridian | Idaho | 83642 | — |
| Deaconess Clinic - Indiana | Evansville | Indiana | 47712 | — |
| Velocity Clinical Research, Valparaiso | Valparaiso | Indiana | 46383 | — |
| Alliance for Multispecialty Research, LLC (AMR) - Newton | Newton | Kansas | 67114 | — |
| University of Louisville - UoL Physicians Outpatient Center | Louisville | Kentucky | 40292 | — |
| Troy Internal Medicine | Troy | Michigan | 48098 | — |
| Clay Platte Family Medicine / CCT Research | Kansas City | Missouri | 64116 | — |
| Velocity Clinical Research - Kearney | Lincoln | Nebraska | 68506 | — |
| Cenexel HRI | Berlin | New Jersey | 08009 | — |
| Velocity Clinical Research - Cincinnati | Cincinnati | Ohio | 45242 | — |
| Velocity Clinical Research - Cleveland | Cleveland | Ohio | 44122 | — |
| Hatboro Medical Associates/ CCT Research | Hatboro | Pennsylvania | 19040 | — |
| Mercado Medical Practice / CCT Research | Philadelphia | Pennsylvania | 19111 | — |
| Palmetto Clinical Reserach | Summerville | South Carolina | 29456 | — |
| Velocity Clinical Research - Union | Union | South Carolina | 29379 | — |
| Apex Mobile Clinical Research | Bellaire | Texas | 77401 | — |
| Pinnacle Clinical Research - San Antonio | San Antonio | Texas | 78229 | — |
| Ogden Clinic, Mount View/CCT Research | Pleasant View | Utah | 84414 | — |
| Velocity Clinical Research - Salt Lake City | Salt Lake City | Utah | 84088 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05889156, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2025 · Synced Sep 15, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05889156 live on ClinicalTrials.gov.