A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

ClinicalTrials.gov ID: NCT05889182

Public ClinicalTrials.gov record NCT05889182. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 5:10 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Efficacy and Safety of Upadacitinib in Adult and Adolescent Subjects With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

Study identification

NCT ID: NCT05889182
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AbbVie; Industry
Enrollment: 1,328 participants

Conditions and interventions

Conditions

Hidradenitis Suppurativa

Interventions

Placebo Drug
Upadacitinib Drug

Drug

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 20, 2023
Primary completion: Feb 29, 2028
Completion: Feb 29, 2028
Last update posted: Mar 3, 2026

2023 – 2028

United States locations

U.S. sites: 87
U.S. states: 28
U.S. cities: 76

Facility	City	State	ZIP	Site status
Cahaba Dermatology & Skin Health Center /ID# 254876	Birmingham	Alabama	35244	Recruiting
Peak Dermatology Aesthetics and Wellness Fountain Hills /ID# 272564	Fountain Hills	Arizona	85268	Recruiting
Medical Dermatology Specialists /ID# 254226	Phoenix	Arizona	85006	Recruiting
Mayo Clinic - Scottsdale /ID# 254388	Scottsdale	Arizona	85259-5452	Recruiting
Banner University Medicine Dermatology /ID# 255853	Tucson	Arizona	85718-1407	Recruiting
Clinical Trials Institute - Northwest Arkansas /ID# 254924	Fayetteville	Arkansas	72703	Recruiting
Burke Pharmaceutical Research /ID# 254238	Hot Springs	Arkansas	71913-6404	Recruiting
Arkansas Research Trials /ID# 254233	North Little Rock	Arkansas	72217	Recruiting
NW Arkansas Clinical Trials Center /ID# 254311	Rogers	Arkansas	72758	Recruiting
Private Practice - Dr. Tooraj Raoof /ID# 254374	Encino	California	91436	Recruiting
Marvel Clinical Research /ID# 276228	Huntington Beach	California	92647	Recruiting
Dermatology Research Associates /ID# 254846	Los Angeles	California	90045	Recruiting
NorCal Clinical Research /ID# 274219	Rocklin	California	95765	Recruiting
Integrative Skin Science and Research /ID# 254930	Sacramento	California	95815	Recruiting
University of California Davis Health /ID# 254229	Sacramento	California	95817	Recruiting
Medderm Associates /ID# 253800	San Diego	California	92103	Completed
Clinical Trials Research Institute /ID# 254466	Thousand Oaks	California	91320-2130	Recruiting
UConn Health Main /ID# 254507	Farmington	Connecticut	06032	Recruiting
Yale University School of Medicine /ID# 254586	New Haven	Connecticut	06510	Recruiting
Skin Care Research Boca Raton /ID# 253814	Boca Raton	Florida	33486-2269	Recruiting
Apex Clinical Trials /ID# 255756	Brandon	Florida	33511	Recruiting
Florida Academic Dermatology Center /ID# 254011	Coral Gables	Florida	33134-5755	Recruiting
Dermatology Associates of the Palm Beaches /ID# 275950	Delray Beach	Florida	33445	Recruiting
Skin Care Research - Hollywood /ID# 254508	Hollywood	Florida	33021-6748	Recruiting
Life Clinical Trials /ID# 258613	Margate	Florida	33063	Recruiting
Skin Care Research - Tampa /ID# 256440	Tampa	Florida	33607-6438	Recruiting
Advanced Clinical Research Institute /ID# 253746	Tampa	Florida	33607	Recruiting
Avita Clinical Research /ID# 254471	Tampa	Florida	33613-1825	Completed
Centricity Research /ID# 255470	Columbus	Georgia	31904-2954	Recruiting
Treasure Valley Medical Research /ID# 255208	Boise	Idaho	83706	Recruiting
DeNova Research /ID# 254372	Chicago	Illinois	60610	Recruiting
Northwestern University Feinberg School of Medicine /ID# 254503	Chicago	Illinois	60611-2927	Recruiting
NorthShore University HealthSystem - Skokie /ID# 254389	Skokie	Illinois	60077	Recruiting
Dawes Fretzin, LLC /ID# 254390	Indianapolis	Indiana	46256	Recruiting
Options Research Group /ID# 254537	West Lafayette	Indiana	47906	Recruiting
U.S. Dermatology Partners Leawood /ID# 255838	Leawood	Kansas	66211-1453	Recruiting
Equity Medical, LLC /ID# 271140	Bowling Green	Kentucky	42104	Recruiting
Massachusetts General Hospital /ID# 261093	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center /ID# 253811	Boston	Massachusetts	02215-5400	Recruiting
Beacon Clinical Research, LLC /ID# 254419	Quincy	Massachusetts	02169	Recruiting
UMass Memorial Medical Center /ID# 258839	Worcester	Massachusetts	01605	Recruiting
The Derm Institute Of West Michigan /ID# 275948	Caledonia	Michigan	49316	Recruiting
Hamzavi Dermatology - Canton /ID# 275856	Canton	Michigan	48187	Recruiting
Michigan Center for Medical Research /ID# 275860	Clarkston	Michigan	48346	Recruiting
Michigan Dermatology Institute /ID# 254468	Waterford	Michigan	48328	Recruiting
Cleaver Dermatology /ID# 254391	Kirksville	Missouri	63501-5362	Recruiting
Dermatology and Skin Center of Lees Summit /ID# 257546	Lee's Summit	Missouri	64064-2301	Recruiting
MediSearch Clinical Trials /ID# 254392	Saint Joseph	Missouri	64506	Recruiting
SSM Health Saint Louis University Hospital /ID# 256437	St Louis	Missouri	63104	Recruiting
Washington University School of Medicine - St. Louis /ID# 254506	St Louis	Missouri	63130	Recruiting
Vivida Dermatology- Flamingo /ID# 254227	Las Vegas	Nevada	89119-5190	Recruiting
Las Vegas Dermatology /ID# 272421	Las Vegas	Nevada	89144	Recruiting
Skin Cancer and Dermatology Institute - Reno /ID# 254410	Reno	Nevada	89509	Recruiting
Empire Dermatology /ID# 276241	East Syracuse	New York	13057	Recruiting
NorthWell Health - Dermatology /ID# 254704	New Hyde Park	New York	11042-2058	Recruiting
Schweiger Dermatology, P.C. /ID# 254232	New York	New York	07044-2946	Completed
Private Practice - Dr. Bobby Buka /ID# 276371	New York	New York	10012	Recruiting
Onsite Clinical Solutions /ID# 254854	Charlotte	North Carolina	28277-3816	Recruiting
Duke University Medical Center /ID# 256898	Durham	North Carolina	27710	Recruiting
Apex Clinical Research Center, LLC /ID# 275956	Canton	Ohio	44718	Recruiting
ClinOhio Research Services /ID# 254851	Columbus	Ohio	43213-4440	Recruiting
Dermatologists of Southwest Ohio, Inc /ID# 254297	Mason	Ohio	45040-4520	Recruiting
Dermatology Partners - Medina /ID# 275939	Medina	Ohio	44256	Recruiting
Lynn Institute of Oklahoma City /ID# 253791	Oklahoma City	Oklahoma	73112	Recruiting
Oregon Health and Science University /ID# 254929	Portland	Oregon	97239	Recruiting
Penn State Milton S. Hershey Medical Center /ID# 254925	Hershey	Pennsylvania	17033-2360	Recruiting
Paddington Testing Co., Inc. /ID# 254394	Philadelphia	Pennsylvania	19103	Completed
Clinical Research of Philadelphia, LLC /ID# 255308	Philadelphia	Pennsylvania	19114	Recruiting
Medical University of South Carolina /ID# 272569	Charleston	South Carolina	29425	Recruiting
Dermatology Associates of Knoxville /ID# 261082	Knoxville	Tennessee	37917	Recruiting
Arlington Research Center, Inc /ID# 253805	Arlington	Texas	76011	Recruiting
Bellaire Dermatology Associates /ID# 253797	Bellaire	Texas	77401	Recruiting
Dermatology Treatment and Research Center /ID# 253795	Dallas	Texas	75230	Completed
Modern Research Associates, PLLC /ID# 253810	Dallas	Texas	75231	Recruiting
HRMD Research Dallas /ID# 255256	Dallas	Texas	75240-6246	Recruiting
Dallas Fort Worth Clinical Research Associates (DFWCRA) /ID# 256438	Grapevine	Texas	76051-3580	Completed
Suzanne Bruce and Associates-Houston /ID# 254228	Houston	Texas	77056	Completed
Texas Dermatology Research Center, LLC /ID# 254928	Plano	Texas	75025	Recruiting
Center for Clinical Studies Webster TX /ID# 254242	Webster	Texas	77598	Recruiting
Cope Family Medicine - Ogden Clinic /ID# 276227	Bountiful	Utah	84010	Recruiting
University of Utah /ID# 254452	Murray	Utah	84107	Recruiting
Springville Dermatology - Springville /ID# 276225	Springville	Utah	84663	Recruiting
University of Virginia - Dermatology /ID# 254535	Charlottesville	Virginia	22903	Recruiting
The Education & Research Foundation, Inc. /ID# 254852	Lynchburg	Virginia	24501-1403	Recruiting
Virginia Clinical Research /ID# 254538	Norfolk	Virginia	23507	Recruiting
Frontier Dermatology /ID# 254554	Mill Creek	Washington	98012	Recruiting
Premier Clinical Research /ID# 254847	Spokane	Washington	99202	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 198 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05889182, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 3, 2026 · Synced Apr 22, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05889182 live on ClinicalTrials.gov.

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