Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
Public ClinicalTrials.gov record NCT05899608. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multiregional Phase 3 Study of Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer (HARMONi-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3 Randomized, double-blind, Multiregional Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer. The primary endpoint is overall survival and progression free survival assessed by investigator. The key secondary endpoints include response and safety.
Study identification
- NCT ID
- NCT05899608
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 26, 2023 (Actual)
- Primary completion
- Dec 31, 2028 (Estimated)
- Completion
- Dec 31, 2029 (Estimated)
- Last update posted
- Oct 8, 2026
2023 – 2029
United States locations
- U.S. sites
- 76
- U.S. states
- 28
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center | Phoenix | Arizona | 85006 | — |
| TMC Healthcare | Tucson | Arizona | 85711 | — |
| Genesis Cancer and Blood Institute | Hot Springs | Arkansas | 71913 | — |
| University of Arkansas | Little Rock | Arkansas | 72205 | — |
| LA Cancer Network | Anaheim | California | 92801 | — |
| The Oncology Institute of Hope & Innovation | Cerritos | California | 90703 | — |
| University of Southern California (USC) | Los Angeles | California | 90033 | — |
| Cedar Sinai Medical Center | Los Angeles | California | 90048 | — |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | — |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of California Los Angeles (UCLA) | Santa Monica | California | 90404 | — |
| Providence Medical Foundation | Santa Rosa | California | 95403 | — |
| Kaiser Permanente | Vallejo | California | 94589 | — |
| Rocky Mountain Cancer | Lone Tree | Colorado | 80124 | — |
| Banner MD Anderson Cancer Center at North Colorado Medical Center | Loveland | Colorado | 80538 | — |
| Hartford Hospital | Hartford | Connecticut | 06053 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| Florida Cancer Specialists & Research Institute (FCS)-East | Fort Myers | Florida | 33901 | — |
| BioResearch Partner- Hialeah Hospital | Hialeah | Florida | 33013 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | — |
| Ocala Oncology | Ocala | Florida | 34474 | — |
| Cancer Care of Brevard | Palm Bay | Florida | 32901 | — |
| Ascension Sacred Heart Health System | Pensacola | Florida | 32504 | — |
| Exigent Network | Petersburg | Florida | 33709 | — |
| BRCR Medical Center Inc | Plantation | Florida | 33322 | — |
| Florida Cancer Specialists & Research Institute (FCS) - North | St. Petersburg | Florida | 33705 | — |
| BRCR Medical Center Inc. | Tamarac | Florida | 33321 | — |
| Florida Cancer Specialists & Research Institute (FCS)-South | West Palm Beach | Florida | 33401 | — |
| Central Georgia Cancer Care | Macon | Georgia | 31210 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Illinois Cancer Care P.C. | Peoria | Illinois | 61615 | — |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | — |
| Baptist Health | Lexington | Kentucky | 40503 | — |
| Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21187 | — |
| Ascension Saint Agnes Hospital | Baltimore | Maryland | 21229 | — |
| Lahey Hospital | Burlington | Massachusetts | 01805 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Trinity Health | Ann Arbor | Michigan | 48197 | — |
| Karmanos Cancer Insitute | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Park Nicollet Institute | Saint Paul | Minnesota | 55101 | — |
| American Oncology Partners, PA | Kansas City | Missouri | 64132 | — |
| Washington University St.Louis | St Louis | Missouri | 63110 | — |
| St. Vincent Cancer Center | Billings | Montana | 59102 | — |
| University of Nebraska Medical Center (UNMC) | Omaha | Nebraska | 68105 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Mount Sinai | New York | New York | 10029 | — |
| Memorial Sloan Kettering | New York | New York | 10065 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| Levine Center | Charlotte | North Carolina | 28204 | — |
| Oncology Hematology Care (OHC), Inc | Cincinnati | Ohio | 45242 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Willamette Valley Cancer Institute and Research Center (WVCI) | Eugene | Oregon | 97401 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Prisma Health-Upstate | Greenville | South Carolina | 29605 | — |
| West Cancer Center | Memphis | Tennessee | 38138 | — |
| SCRI-Nashville | Nashville | Tennessee | 37203 | — |
| Texas Oncology- Austin | Austin | Texas | 78745 | — |
| Texas Oncology-Dallas | Dallas | Texas | 75246 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Texas Oncology-San Antonio | San Antonio | Texas | 78216 | — |
| Texas Oncology-Tyler | Tyler | Texas | 75702 | — |
| University of Texas at Tyler | Tyler | Texas | 75708 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Virginia Cancer | Reston | Virginia | 20190 | — |
| Swedish Cancer Institute | Seattle | Washington | 98103 | — |
| Cancer Care NW Centers | Spokane | Washington | 99202 | — |
| Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 184 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05899608, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05899608 live on ClinicalTrials.gov.