Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

ClinicalTrials.gov ID: NCT05899608

Public ClinicalTrials.gov record NCT05899608. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 4, 2026, 3:25 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Multiregional Phase 3 Study of Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer (HARMONi-3)

Study identification

NCT ID: NCT05899608
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Summit Therapeutics; Industry
Enrollment: 1,600 participants

Conditions and interventions

Conditions

Non-Small Cell Lung Cancer

Interventions

Ivonescimab Injection Biological
Pembrolizumab Injection Biological

Biological

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 25, 2023
Primary completion: Dec 30, 2028
Completion: Dec 30, 2029
Last update posted: Apr 29, 2026

2023 – 2029

United States locations

U.S. sites: 76
U.S. states: 28
U.S. cities: 63

Facility	City	State	ZIP	Site status
Banner University Medical Center	Phoenix	Arizona	85006	Recruiting
TMC Healthcare	Tucson	Arizona	85711	Recruiting
Genesis Cancer and Blood Institute	Hot Springs	Arkansas	71913	Recruiting
University of Arkansas	Little Rock	Arkansas	72205	Recruiting
LA Cancer Network	Anaheim	California	92801	Recruiting
The Oncology Institute of Hope & Innovation	Cerritos	California	90703	Recruiting
University of Southern California (USC)	Los Angeles	California	90033	Recruiting
Cedar Sinai Medical Center	Los Angeles	California	90048	Recruiting
Valkyrie Clinical Trials	Los Angeles	California	90067	Recruiting
Sutter Institute for Medical Research	Sacramento	California	95816	Recruiting
UC Davis Medical Center	Sacramento	California	95817	Recruiting
University of California Los Angeles (UCLA)	Santa Monica	California	90404	Recruiting
Providence Medical Foundation	Santa Rosa	California	95403	Recruiting
Kaiser Permanente	Vallejo	California	94589	Recruiting
Rocky Mountain Cancer	Lone Tree	Colorado	80124	Recruiting
Banner MD Anderson Cancer Center at North Colorado Medical Center	Loveland	Colorado	80538	Recruiting
Hartford Hospital	Hartford	Connecticut	06053	Recruiting
Yale University	New Haven	Connecticut	06510	Recruiting
Florida Cancer Specialists & Research Institute (FCS)-East	Fort Myers	Florida	33901	Recruiting
BioResearch Partner- Hialeah Hospital	Hialeah	Florida	33013	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
Cancer Specialists of North Florida	Jacksonville	Florida	32256	Recruiting
Ocala Oncology	Ocala	Florida	34474	Recruiting
Cancer Care of Brevard	Palm Bay	Florida	32901	Recruiting
Memorial Cancer Institute	Pembroke Pines	Florida	33028	Recruiting
Ascension Sacred Heart Health System	Pensacola	Florida	32504	Recruiting
BRCR Medical Center Inc	Plantation	Florida	33322	Recruiting
Florida Cancer Specialists & Research Institute (FCS) - North	St. Petersburg	Florida	33705	Recruiting
Exigent Network	St. Petersburg	Florida	33709	Recruiting
BRCR Medical Center Inc.	Tamarac	Florida	33321	Recruiting
Florida Cancer Specialists & Research Institute (FCS)-South	West Palm Beach	Florida	33401	Recruiting
Central Georgia Cancer Care	Macon	Georgia	31210	Recruiting
Northwestern Memorial Hospital	Chicago	Illinois	60611	Recruiting
Illinois Cancer Care	Peoria	Illinois	61615	Recruiting
University of Kansas Cancer Center	Westwood	Kansas	66205	Recruiting
Baptist Health	Lexington	Kentucky	40503	Recruiting
Sidney Kimmel Comprehensive Cancer Center	Baltimore	Maryland	21187	Recruiting
Ascension Saint Agnes Hospital	Baltimore	Maryland	21229	Recruiting
Lahey Hospital	Burlington	Massachusetts	01805	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Trinity Health	Ann Arbor	Michigan	48197	Recruiting
Karmanos Cancer Insitute	Detroit	Michigan	48201	Recruiting
Henry Ford Hospital	Detroit	Michigan	48202	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Park Nicollet Institute	Saint Paul	Minnesota	55101	Recruiting
American Oncology Partners, PA	Kansas City	Missouri	64132	Recruiting
Washington University St.Louis	St Louis	Missouri	63110	Recruiting
St. Vincent Cancer Center	Billings	Montana	59102	Recruiting
University of Nebraska Medical Center (UNMC)	Omaha	Nebraska	68105	Recruiting
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
Mount Sinai	New York	New York	10029	Recruiting
Memorial Sloan Kettering	New York	New York	10065	Recruiting
SUNY Upstate Medical University	Syracuse	New York	13210	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27514	Recruiting
Levine Center	Charlotte	North Carolina	28204	Recruiting
Oncology Hematology Care (OHC), Inc	Cincinnati	Ohio	45242	Recruiting
University Hospitals Case Medical Center	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Willamette Valley Cancer Institute and Research Center (WVCI)	Eugene	Oregon	97401	Recruiting
Medical University of South Carolina (MUSC)	Charleston	South Carolina	29425	Recruiting
Prisma Health-Upstate	Greenville	South Carolina	29605	Recruiting
West Cancer Center	Memphis	Tennessee	38138	Recruiting
SCRI-Nashville	Nashville	Tennessee	37203	Recruiting
Texas Oncology- Austin	Austin	Texas	78745	Recruiting
Texas Oncology-Dallas	Dallas	Texas	75246	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Texas Oncology-San Antonio	San Antonio	Texas	78216	Recruiting
Texas Oncology-Tyler	Tyler	Texas	75702	Recruiting
University of Texas at Tyler	Tyler	Texas	75708	Recruiting
Virginia Oncology Associates	Norfolk	Virginia	23502	Recruiting
Virginia Cancer	Reston	Virginia	20190	Recruiting
Swedish Cancer Institute	Seattle	Washington	98103	Recruiting
Cancer Care NW Centers	Spokane	Washington	99202	Recruiting
Carbone Cancer Center	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 177 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05899608, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 29, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05899608 live on ClinicalTrials.gov.

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