ClinicalTrials.gov record
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
ClinicalTrials.gov ID: NCT05899608
Public ClinicalTrials.gov record NCT05899608. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multiregional Phase 3 Study of Ivonescimab Combined With Chemotherapy Versus Pembrolizumab Combined With Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer (HARMONi-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 3 Randomized, double-blind, Multiregional Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer. The primary endpoint is overall survival and progression free survival assessed by investigator. The key secondary endpoints include response and safety.
Study identification
- NCT ID
- NCT05899608
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,600 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 25, 2023
- Primary completion
- Dec 30, 2028
- Completion
- Dec 30, 2029
- Last update posted
- Aug 23, 2026
2023 – 2029
United States locations
- U.S. sites
- 76
- U.S. states
- 28
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center | Phoenix | Arizona | 85006 | Active, not recruiting |
| TMC Healthcare | Tucson | Arizona | 85711 | Active, not recruiting |
| Genesis Cancer and Blood Institute | Hot Springs | Arkansas | 71913 | Active, not recruiting |
| University of Arkansas | Little Rock | Arkansas | 72205 | Active, not recruiting |
| LA Cancer Network | Anaheim | California | 92801 | Active, not recruiting |
| The Oncology Institute of Hope & Innovation | Cerritos | California | 90703 | Active, not recruiting |
| University of Southern California (USC) | Los Angeles | California | 90033 | Active, not recruiting |
| Cedar Sinai Medical Center | Los Angeles | California | 90048 | Active, not recruiting |
| Valkyrie Clinical Trials | Los Angeles | California | 90067 | Active, not recruiting |
| Sutter Institute for Medical Research | Sacramento | California | 95816 | Active, not recruiting |
| UC Davis Medical Center | Sacramento | California | 95817 | Active, not recruiting |
| University of California Los Angeles (UCLA) | Santa Monica | California | 90404 | Active, not recruiting |
| Providence Medical Foundation | Santa Rosa | California | 95403 | Active, not recruiting |
| Kaiser Permanente | Vallejo | California | 94589 | Active, not recruiting |
| Rocky Mountain Cancer | Lone Tree | Colorado | 80124 | Active, not recruiting |
| Banner MD Anderson Cancer Center at North Colorado Medical Center | Loveland | Colorado | 80538 | Active, not recruiting |
| Hartford Hospital | Hartford | Connecticut | 06053 | Active, not recruiting |
| Yale University | New Haven | Connecticut | 06510 | Active, not recruiting |
| Florida Cancer Specialists & Research Institute (FCS)-East | Fort Myers | Florida | 33901 | Active, not recruiting |
| BioResearch Partner- Hialeah Hospital | Hialeah | Florida | 33013 | Active, not recruiting |
| Memorial Healthcare System | Hollywood | Florida | 33021 | Active, not recruiting |
| Mayo Clinic | Jacksonville | Florida | 32224 | Active, not recruiting |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | Active, not recruiting |
| Ocala Oncology | Ocala | Florida | 34474 | Active, not recruiting |
| Cancer Care of Brevard | Palm Bay | Florida | 32901 | Active, not recruiting |
| Ascension Sacred Heart Health System | Pensacola | Florida | 32504 | Active, not recruiting |
| Exigent Network | Petersburg | Florida | 33709 | Active, not recruiting |
| BRCR Medical Center Inc | Plantation | Florida | 33322 | Active, not recruiting |
| Florida Cancer Specialists & Research Institute (FCS) - North | St. Petersburg | Florida | 33705 | Active, not recruiting |
| BRCR Medical Center Inc. | Tamarac | Florida | 33321 | Active, not recruiting |
| Florida Cancer Specialists & Research Institute (FCS)-South | West Palm Beach | Florida | 33401 | Active, not recruiting |
| Central Georgia Cancer Care | Macon | Georgia | 31210 | Active, not recruiting |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | Active, not recruiting |
| Illinois Cancer Care P.C. | Peoria | Illinois | 61615 | Active, not recruiting |
| University of Kansas Cancer Center | Westwood | Kansas | 66205 | Active, not recruiting |
| Baptist Health | Lexington | Kentucky | 40503 | Active, not recruiting |
| Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21187 | Active, not recruiting |
| Ascension Saint Agnes Hospital | Baltimore | Maryland | 21229 | Active, not recruiting |
| Lahey Hospital | Burlington | Massachusetts | 01805 | Active, not recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Active, not recruiting |
| Trinity Health | Ann Arbor | Michigan | 48197 | Active, not recruiting |
| Karmanos Cancer Insitute | Detroit | Michigan | 48201 | Active, not recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Active, not recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Active, not recruiting |
| Park Nicollet Institute | Saint Paul | Minnesota | 55101 | Active, not recruiting |
| American Oncology Partners, PA | Kansas City | Missouri | 64132 | Active, not recruiting |
| Washington University St.Louis | St Louis | Missouri | 63110 | Active, not recruiting |
| St. Vincent Cancer Center | Billings | Montana | 59102 | Active, not recruiting |
| University of Nebraska Medical Center (UNMC) | Omaha | Nebraska | 68105 | Active, not recruiting |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Active, not recruiting |
| Mount Sinai | New York | New York | 10029 | Active, not recruiting |
| Memorial Sloan Kettering | New York | New York | 10065 | Active, not recruiting |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | Active, not recruiting |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | Active, not recruiting |
| Levine Center | Charlotte | North Carolina | 28204 | Active, not recruiting |
| Oncology Hematology Care (OHC), Inc | Cincinnati | Ohio | 45242 | Active, not recruiting |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | Active, not recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Active, not recruiting |
| Willamette Valley Cancer Institute and Research Center (WVCI) | Eugene | Oregon | 97401 | Active, not recruiting |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | Active, not recruiting |
| Prisma Health-Upstate | Greenville | South Carolina | 29605 | Active, not recruiting |
| West Cancer Center | Memphis | Tennessee | 38138 | Active, not recruiting |
| SCRI-Nashville | Nashville | Tennessee | 37203 | Active, not recruiting |
| Texas Oncology- Austin | Austin | Texas | 78745 | Active, not recruiting |
| Texas Oncology-Dallas | Dallas | Texas | 75246 | Active, not recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Active, not recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Active, not recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Active, not recruiting |
| Texas Oncology-San Antonio | San Antonio | Texas | 78216 | Active, not recruiting |
| Texas Oncology-Tyler | Tyler | Texas | 75702 | Active, not recruiting |
| University of Texas at Tyler | Tyler | Texas | 75708 | Active, not recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Active, not recruiting |
| Virginia Cancer | Reston | Virginia | 20190 | Active, not recruiting |
| Swedish Cancer Institute | Seattle | Washington | 98103 | Active, not recruiting |
| Cancer Care NW Centers | Spokane | Washington | 99202 | Active, not recruiting |
| Carbone Cancer Center | Madison | Wisconsin | 53792 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 184 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05899608, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 11, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05899608 live on ClinicalTrials.gov.