ClinicalTrials.gov record
Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer
ClinicalTrials.gov ID: NCT05904080
Public ClinicalTrials.gov record NCT05904080. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:08 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Phase 2 Study of Nivolumab and Ipilimumab With or Without Cabozantinib in Patients With Advanced Nasopharyngeal Carcinoma That Have Progressed After Platinum Treatment and Immunotherapy
Study identification
- NCT ID
- NCT05904080
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 50 participants
Conditions and interventions
Conditions
Interventions
- Biospecimen Collection Procedure
- Cabozantinib S-malate Drug
- Computed Tomography Procedure
- Ipilimumab Biological
- Magnetic Resonance Imaging Procedure
- Nivolumab Biological
Procedure · Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 18, 2024
- Primary completion
- Jun 15, 2028
- Completion
- Jun 15, 2028
- Last update posted
- May 6, 2026
2024 – 2028
United States locations
- U.S. sites
- 92
- U.S. states
- 23
- U.S. cities
- 75
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | Recruiting |
| Keck Medicine of USC Koreatown | Los Angeles | California | 90020 | Recruiting |
| Los Angeles General Medical Center | Los Angeles | California | 90033 | Recruiting |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| USC Norris Oncology/Hematology-Newport Beach | Newport Beach | California | 92663 | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | Recruiting |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | Recruiting |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | Recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Suspended |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Suspended |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Suspended |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Illinois | Chicago | Illinois | 60612 | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | Recruiting |
| Carle at The Riverfront | Danville | Illinois | 61832 | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | Recruiting |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | Recruiting |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | Recruiting |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | Recruiting |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | Recruiting |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | Recruiting |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | 60035 | Recruiting |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | Recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | Recruiting |
| Northwestern Medicine Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | Recruiting |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | Recruiting |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | Recruiting |
| Heartland Oncology and Hematology LLP | Council Bluffs | Iowa | 51503 | Suspended |
| Methodist Jennie Edmundson Hospital | Council Bluffs | Iowa | 51503 | Recruiting |
| Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ | Council Bluffs | Iowa | 51503 | Suspended |
| Iowa Methodist Medical Center | Des Moines | Iowa | 50309 | Recruiting |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic | Des Moines | Iowa | 50309 | Recruiting |
| Mercy Medical Center - Des Moines | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic | Des Moines | Iowa | 50314 | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic | Waukee | Iowa | 50263 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | Recruiting |
| Mercy Hospital South | St Louis | Missouri | 63128 | Recruiting |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | Recruiting |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | Recruiting |
| Bozeman Health Deaconess Hospital | Bozeman | Montana | 59715 | Recruiting |
| Benefis Sletten Cancer Institute | Great Falls | Montana | 59405 | Recruiting |
| Logan Health Medical Center | Kalispell | Montana | 59901 | Recruiting |
| Community Medical Center | Missoula | Montana | 59804 | Recruiting |
| Nebraska Cancer Specialists/Oncology Hematology West PC - MECC | Omaha | Nebraska | 68114 | Recruiting |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | Recruiting |
| Oncology Associates PC | Omaha | Nebraska | 68114 | Suspended |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | Recruiting |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | Recruiting |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | Recruiting |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | Recruiting |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | Recruiting |
| UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | 27599 | Recruiting |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | Recruiting |
| Novant Health Cancer Institute - Huntersville | Huntersville | North Carolina | 28078 | Recruiting |
| Novant Health Cancer Institute - Matthews | Matthews | North Carolina | 28105 | Recruiting |
| Novant Health Cancer Institute - Mooresville | Mooresville | North Carolina | 28117 | Recruiting |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | Recruiting |
| Sanford Broadway Medical Center | Fargo | North Dakota | 58122 | Recruiting |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | Recruiting |
| Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | 45220 | Recruiting |
| Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | 73505 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Oklahoma Cancer Specialists and Research Institute-Tulsa | Tulsa | Oklahoma | 74146 | Suspended |
| Saint Alphonsus Cancer Care Center-Ontario | Ontario | Oregon | 97914 | Suspended |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | Recruiting |
| Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | 57104 | Recruiting |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | Recruiting |
| Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | 37232 | Recruiting |
| VCU Massey Cancer Center at Stony Point | Richmond | Virginia | 23235 | Recruiting |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | Recruiting |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | Recruiting |
| Camden Clark Medical Center | Parkersburg | West Virginia | 26101 | Recruiting |
| Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | 54701 | Recruiting |
| Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | 54449 | Recruiting |
| Marshfield Medical Center - Minocqua | Minocqua | Wisconsin | 54548 | Recruiting |
| Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | 54868 | Recruiting |
| Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | 54482 | Recruiting |
| Marshfield Medical Center - Weston | Weston | Wisconsin | 54476 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05904080, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 6, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05904080 live on ClinicalTrials.gov.