Study of ALTO-300 in MDD
Public ClinicalTrials.gov record NCT05922878. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study of ALTO-300 With an Open-Label Extension in Adults With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine efficacy differences between ALTO-300 and placebo, used adjunctively to an antidepressant, related to patient characteristics.
Study identification
- NCT ID
- NCT05922878
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 321 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 8, 2023 (Actual)
- Primary completion
- Dec 2026 (Estimated)
- Completion
- Dec 2026 (Estimated)
- Last update posted
- Jul 24, 2025
2023 – 2026
United States locations
- U.S. sites
- 45
- U.S. states
- 21
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Site 200 | Phoenix | Arizona | 85012 | Recruiting |
| Site 189 | Phoenix | Arizona | 85021 | Withdrawn |
| Site 187 | Yuma | Arizona | 85364 | Recruiting |
| Site 193 | Rogers | Arkansas | 72758 | Recruiting |
| Site 218 | Bellflower | California | 90706 | Recruiting |
| Site 217 | Glendale | California | 91206 | Recruiting |
| Site 335 | Lafayette | California | 94549 | Recruiting |
| Site 209 | Los Angeles | California | 90064 | Recruiting |
| Site 219 | Mather | California | 95655 | Recruiting |
| Site 194 | Mission Viejo | California | 92691 | Recruiting |
| Site 197 | Temecula | California | 92591 | Recruiting |
| Site 203 | Colorado Springs | Colorado | 80918 | Recruiting |
| Site 349 | Evergreen | Colorado | 80439 | Recruiting |
| Site 214 | Norwalk | Connecticut | 06851 | Recruiting |
| Site 159 | Clermont | Florida | 34711 | Recruiting |
| Site 225 | Miami Gardens | Florida | 33014 | Recruiting |
| Site 190 | Miami Lakes | Florida | 33016 | Recruiting |
| Site 161 | Okeechobee | Florida | 34972 | Recruiting |
| Site 221 | Tampa | Florida | 33629 | Recruiting |
| Site 220 | West Palm Beach | Florida | 33407 | Recruiting |
| Site 224 | Savannah | Georgia | 31405 | Recruiting |
| Site 208 | Snellville | Georgia | 30078 | Recruiting |
| Site 119 | Boise | Idaho | 83702 | Recruiting |
| Site 310 | Chicago | Illinois | 60634 | Recruiting |
| Site 201 | Marrero | Louisiana | 70072 | Terminated |
| Site 198 | Monroe | Louisiana | 71201 | Terminated |
| Site 215 | Jackson | Mississippi | 39216 | Recruiting |
| Site 344 | Las Vegas | Nevada | 89102 | Recruiting |
| Site 114 | Albuquerque | New Mexico | 87108 | Recruiting |
| Site 191 | Rochester | New York | 14618 | Terminated |
| Site 192 | Staten Island | New York | 10314 | Recruiting |
| Site 199 | Hickory | North Carolina | 28601 | Recruiting |
| Site 202 | Cincinnati | Ohio | 45215 | Recruiting |
| Site 195 | Oklahoma City | Oklahoma | 73112 | Recruiting |
| Site 216 | Allentown | Pennsylvania | 18104 | Recruiting |
| Site 350 | Media | Pennsylvania | 19063 | Recruiting |
| Site 352 | Moosic | Pennsylvania | 18507 | Recruiting |
| Site 102 | Dallas | Texas | 75235 | Withdrawn |
| Site 347 | Fort Worth | Texas | 76104 | Recruiting |
| Site 148 | Fort Worth | Texas | 76244 | Withdrawn |
| Site 206 | Missouri City | Texas | 77459 | Withdrawn |
| Site 353 | Plano | Texas | 75093 | Not yet recruiting |
| Site 196 | Richmond | Texas | 77407 | Recruiting |
| Site 207 | Clinton | Utah | 84015 | Recruiting |
| Site 211 | Roanoke | Virginia | 24018 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05922878, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 24, 2025 · Synced Oct 2, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05922878 live on ClinicalTrials.gov.