Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)
Public ClinicalTrials.gov record NCT05934526. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to determine the effect of seralutinib on improving exercise capacity in subjects with WHO Group 1 PAH who are FC II or III. The secondary objective for this trial is to determine time to clinical worsening.
Study identification
- NCT ID
- NCT05934526
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 390 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2023 (Actual)
- Primary completion
- Nov 27, 2025 (Actual)
- Completion
- Dec 22, 2025 (Actual)
- Last update posted
- May 19, 2026
2023 – 2025
United States locations
- U.S. sites
- 50
- U.S. states
- 28
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Valley Advanced Lung Diseases Institute | Fresno | California | 93711 | — |
| Keck Medical Center of USC | Los Angeles | California | 90033 | — |
| Dept of Veterans Affairs Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California, Irvine Medical Center | Orange | California | 92868 | — |
| UC Davis Health | Sacramento | California | 95817 | — |
| Stanford Healthcare | Stanford | California | 94305 | — |
| Winchester Center for Lung Disease | New Haven | Connecticut | 06519 | — |
| The George Washington University Medical Faculty Associates | Washington D.C. | District of Columbia | 20037 | — |
| University of Florida Clinical Research Center | Gainesville | Florida | 32610 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead | Atlanta | Georgia | 30309 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Northside Hospital Laboratory - Atlanta | Atlanta | Georgia | 30342 | — |
| UI Health Hospital | Chicago | Illinois | 60612 | — |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Norton Hospital | Louisville | Kentucky | 40202 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| M Health Fairview University of Minnesota Medical Center - East Bank | Minneapolis | Minnesota | 55455 | — |
| University of Missouri | Columbia | Missouri | 65212 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| University of New Mexico Health Sciences Center | Albuquerque | New Mexico | 87131 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| University of Rochester Medical Center | Rochester | New York | 14642 | — |
| UNC Hospitals | Chapel Hill | North Carolina | 27514 | — |
| Duke University Medical Center - Duke South | Durham | North Carolina | 27710 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| INTEGRIS Cardiovascular Physicians, LLC | Oklahoma City | Oklahoma | 73112 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| The Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Temple Heart and Vascular Institute (Outpatient Clinic) | Philadelphia | Pennsylvania | 19140 | — |
| UPMC Presbyterian Hospital | Pittsburgh | Pennsylvania | 15213 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina - Nexus Research Center | Charleston | South Carolina | 29425 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| CHI St. Luke's Health Baylor College of Medicine Medical Center | Houston | Texas | 77030 | — |
| Houston Methodist Outpatient Center | Houston | Texas | 77030 | — |
| Baylor Scott & White Medical Center - The Heart Hospital | Plano | Texas | 75024 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | 22042 | — |
| Pulmonary Associates of Richmond, Inc. | Richmond | Virginia | 23230 | — |
| Advocate Aurora Health-Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Froedtert Hospital/Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 116 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05934526, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 19, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05934526 live on ClinicalTrials.gov.