Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

ClinicalTrials.gov ID: NCT05943535

Public ClinicalTrials.gov record NCT05943535. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

Study identification

NCT ID: NCT05943535
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: United Therapeutics; Industry
Enrollment: 698 participants

Conditions and interventions

Conditions

Interventions

Inhaled Treprostinil Drug
Placebo Drug
Treprostinil Ultrasonic Nebulizer Device

Drug · Device

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 29, 2023
Primary completion: Oct 31, 2027
Completion: Oct 31, 2027
Last update posted: May 6, 2026

2023 – 2027

United States locations

U.S. sites: 69
U.S. states: 27
U.S. cities: 60

Facility	City	State	ZIP	Site status
UAB Lung Health Center	Birmingham	Alabama	35233	Recruiting
Banner University Medical Center Phoenix Lung Institute	Phoenix	Arizona	85006	Recruiting
Norton Thoracic Institute	Phoenix	Arizona	85013	Recruiting
Peter Morton Medical Building	Los Angeles	California	90095	Recruiting
NewportNativeMD, Inc.	Newport Beach	California	92663	Recruiting
University of California Irvine Medical Center	Orange	California	92868	Recruiting
Paradigm Clinical Research	Redding	California	45227	Recruiting
UC Davis Health Medical Center	Sacramento	California	95817	Recruiting
Paradigm Clinical Research	San Diego	California	92108	Recruiting
Stanford University Medical Center	Stanford	California	94305	Recruiting
Georgetown University Hospital	Washington D.C.	District of Columbia	20007	Recruiting
Ascension Medical Group St. Vincent's Lung Institute	Jacksonville	Florida	32204	Recruiting
Mayo Clinic	Jacksonville	Florida	32224	Recruiting
TGH/USF Center for Advanced Lung Disease and Lung Transplant	Tampa	Florida	33606	Recruiting
The Emory Clinic	Atlanta	Georgia	45227	Recruiting
Northwestern Memorial Hospital, Clinical Research Unit	Chicago	Illinois	60611	Recruiting
Rush University Medical Center Outpatient Pulmonary Clinic	Chicago	Illinois	60612	Recruiting
UI Health Hospital	Chicago	Illinois	60612	Recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
University of Kentucky	Lexington	Kentucky	45227	Recruiting
University of Louisville Healthcare Outpatient Research Clinic	Louisville	Kentucky	40202	Recruiting
Tulane Medical Center	New Orleans	Louisiana	45227	Recruiting
Johns Hopkins Asthma and Allergy Center	Baltimore	Maryland	21224	Recruiting
University of Maryland Medical Center	Baltimore	Maryland	45227	Recruiting
Adventist Healthcare White Oak Medical Center	Silver Spring	Maryland	20904	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Infinity Medical Center	North Dartmouth	Massachusetts	02747	Recruiting
Beaumont Hospital, Royal Oak	Royal Oak	Michigan	48073	Recruiting
University of Minnesota Health Clinical Research Unit (CRU)	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Memorial Hospital at Gulfport	Gulfport	Mississippi	39501	Recruiting
The Lung Research Center, LLC	Chesterfield	Missouri	63017	Recruiting
Saint Luke's Hospital of Kansas City	Kansas City	Missouri	64111	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
University of New Mexico	Albuquerque	New Mexico	87131	Recruiting
Northwell Health	New Hyde Park	New York	11042	Recruiting
Weill Cornell Medicine, New York-Presbyterian Hospital	New York	New York	10065	Recruiting
Stony Brook Advanced Specialty Care	Stony Brook	New York	11794-8172	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
PulmonIx LLC	Greensboro	North Carolina	27403	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Wake Forest Baptist Health	Winston-Salem	North Carolina	27104	Recruiting
University of Cincinnati Medical Center	Cincinnati	Ohio	45219	Recruiting
The Ohio State University Wexner Medical CEnter	Columbus	Ohio	43201	Recruiting
Mercy Health St.Vincent Medical Center LLC	Toledo	Ohio	43608	Recruiting
Pennsylvania State Hershey Medical Center and College of Medicine	Hershey	Pennsylvania	17033	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
Temple University Hospital	Philadelphia	Pennsylvania	19140	Recruiting
Medical University of South Carolina-Nexus	Charleston	South Carolina	29425	Recruiting
Prisma Health Pulmonology-Richland	Columbia	South Carolina	29203	Recruiting
Clinical Trials Center of Middle Tennessee, LLC	Franklin	Tennessee	37067	Recruiting
StatCare Pulmonary Consultants, PLLC	Knoxville	Tennessee	37919	Recruiting
The Vanderbilt Lung Institute	Nashville	Tennessee	37204	Recruiting
Baylor University Medical Center	Dallas	Texas	75246	Recruiting
UT Southwestern Medical Center-Advanced Lung Clinic	Dallas	Texas	75390	Recruiting
Houston Methodist Outpatient Center	Houston	Texas	77030	Recruiting
The University of Texas Health Science Center at Houston, McGovern Medical School	Houston	Texas	77030	Recruiting
A & A Research Consultants, LLC	McAllen	Texas	78503	Recruiting
Metroplex Pulmonary and Sleep Center	McKinney	Texas	75069	Recruiting
Intermountain Medical Center	Murray	Utah	84107	Recruiting
University of Utah Health	Salt Lake City	Utah	84108	Recruiting
University of Virginia Health System	Charlottesville	Virginia	22903	Recruiting
Christopher King, MD	Falls Church	Virginia	22042	Recruiting
Pulmonary Associates of Richmond, Inc.	Richmond	Virginia	23230	Recruiting
University Hospital and UW Health Clinics	Madison	Wisconsin	53792	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226-1222	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05943535, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05943535 live on ClinicalTrials.gov.

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