Strategy for Improving Stroke Treatment Response
Public ClinicalTrials.gov record NCT05948566. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Strategy for Improving Stroke Treatment Response (SISTER) Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
SISTER is a Phase-II, prospective, randomized, placebo-controlled, blinded, dose finding trial that aims to determine the safety and preliminary efficacy of TS23, a monoclonal antibody against the alpha-2 antiplasmin (a2-AP), in acute ischemic stroke.
Study identification
- NCT ID
- NCT05948566
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 300 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 18, 2024 (Actual)
- Primary completion
- Jul 2028 (Estimated)
- Completion
- Dec 2028 (Estimated)
- Last update posted
- Oct 19, 2026
2024 – 2028
United States locations
- U.S. sites
- 52
- U.S. states
- 28
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Hospital | Birmingham | Alabama | 35233 | Recruiting |
| Banner University Medical Center | Phoenix | Arizona | 85006 | Recruiting |
| Mayo Clinic Phoenix | Phoenix | Arizona | 85054 | Withdrawn |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | Recruiting |
| UCSD Health La Jolla | La Jolla | California | 92093 | Recruiting |
| Kaiser Permanente Los Angeles | Los Angeles | California | 90027 | Recruiting |
| Sutter Medical Center | Sacramento | California | 95816 | Withdrawn |
| UCSD Medical Center- Hillcrest Hospital | San Diego | California | 92103 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Yale New Haven Hospital | New Haven | Connecticut | 06511 | Recruiting |
| Christiana Hospital | Newark | Delaware | 19718 | Withdrawn |
| UF Health Shands Hospital | Gainesville | Florida | 32608 | Terminated |
| Jackson Memorial Hospital | Miami | Florida | 33136 | Recruiting |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | Recruiting |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | Active, not recruiting |
| University of Iowa Hospitals & Clinics | Iowa City | Iowa | 52242 | Withdrawn |
| Baptist Healthcare System, Inc. | Lexington | Kentucky | 40503 | Recruiting |
| University of Louisville Hospital | Louisville | Kentucky | 40202 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02171 | Recruiting |
| M Health Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | Recruiting |
| M Health Fairview Southdale Hospital | Edina | Minnesota | 55435 | Recruiting |
| M Health Fairview University of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | Recruiting |
| United Hospital | Saint Paul | Minnesota | 55102 | Withdrawn |
| Barnes Jewish Hospital | St Louis | Missouri | 63110 | Recruiting |
| JFK Medical Center | Edison | New Jersey | 08837 | Recruiting |
| NYU Langone Health | Brooklyn | New York | 11220 | Recruiting |
| Buffalo General Medical Center | Buffalo | New York | 14203 | Withdrawn |
| North Shore University Hospital | Manhasset | New York | 11030 | Recruiting |
| Mount Sinai West | New York | New York | 10029 | Withdrawn |
| The Mount Sinai Hospital | New York | New York | 10029 | Recruiting |
| NYP Columbia University Medical Center | New York | New York | 10032 | Recruiting |
| SUNY Upstate Medical University | Syracuse | New York | 13202 | Recruiting |
| Westchester Medical Center | Valhalla | New York | 10595 | Withdrawn |
| Duke University Hospital | Durham | North Carolina | 27710 | Recruiting |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | Terminated |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45267 | Recruiting |
| OSU Wexner Medical Center | Columbus | Ohio | 43210 | Recruiting |
| Ascension St. John | Tulsa | Oklahoma | 74104 | Recruiting |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Saint Luke's Hospital of Bethlehem Pennsylvania | Bethlehem | Pennsylvania | 18015 | Recruiting |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | Recruiting |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| Medical University of South Carolina University Hospital | Charleston | South Carolina | 32608 | Recruiting |
| Prisma Health Greenville Memorial | Greenville | South Carolina | 29605 | Recruiting |
| Methodist University Hospital | Memphis | Tennessee | 38104 | Recruiting |
| Memorial Hermann Texas Medical Center | Houston | Texas | 77030 | Recruiting |
| University of Utah Healthcare | Salt Lake City | Utah | 84132 | Withdrawn |
| UVA Medical Center | Charlottesville | Virginia | 22901 | Recruiting |
| VCU Medical Center | Richmond | Virginia | 23298 | Withdrawn |
| Harborview Medical Center | Seattle | Washington | 98104 | Withdrawn |
| Ascension Columbia St. Mary's Hospital | Milwaukee | Wisconsin | 53211 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05948566, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 19, 2026 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05948566 live on ClinicalTrials.gov.