An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)

ClinicalTrials.gov ID: NCT05952557

Public ClinicalTrials.gov record NCT05952557. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:23 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease

Study identification

NCT ID: NCT05952557
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 5,500 participants

Conditions and interventions

Conditions

Breast Cancer, Early Breast Cancer

Interventions

Abemaciclib Drug
Anastrozole Drug
Camizestrant Drug
Exemestane Drug
Letrozole Drug
Tamoxifen Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 130 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 4, 2023
Primary completion: Mar 3, 2030
Completion: May 5, 2037
Last update posted: Jun 18, 2025

2023 – 2037

United States locations

U.S. sites: 147
U.S. states: 41
U.S. cities: 131

Facility	City	State	ZIP	Site status
Research Site	Dothan	Alabama	36303	Recruiting
Research Site	Phoenix	Arizona	85054	Recruiting
Research Site	Tucson	Arizona	85745	Recruiting
Research Site	Fayetteville	Arkansas	72703	Recruiting
Research Site	Duarte	California	91010	Recruiting
Research Site	Fountain Valley	California	92708	Recruiting
Research Site	Greenbrae	California	94904	Not yet recruiting
Research Site	Irvine	California	92618	Recruiting
Research Site	La Jolla	California	92093	Recruiting
Research Site	Los Angeles	California	90017	Recruiting
Research Site	Monterey	California	93940	Recruiting
Research Site	Walnut Creek	California	94598	Recruiting
Research Site	West Hollywood	California	90048	Recruiting
Research Site	Aurora	Colorado	80045	Recruiting
Research Site	Littleton	Colorado	80120	Recruiting
Research Site	Littleton	Colorado	80129	Recruiting
Research Site	New Haven	Connecticut	06510	Recruiting
Research Site	Newark	Delaware	19713	Recruiting
Research Site	Washington D.C.	District of Columbia	20016	Not yet recruiting
Research Site	Clearwater	Florida	33756	Recruiting
Research Site	Fort Myers	Florida	33901	Recruiting
Research Site	Gainesville	Florida	32610	Recruiting
Research Site	Jacksonville	Florida	32224	Recruiting
Research Site	Orlando	Florida	32806	Recruiting
Research Site	Pembroke Pines	Florida	33028	Recruiting
Research Site	Plantation	Florida	33322	Recruiting
Research Site	Plantation	Florida	33324	Recruiting
Research Site	St. Petersburg	Florida	33705	Active, not recruiting
Research Site	St. Petersburg	Florida	33709	Recruiting
Research Site	Tallahassee	Florida	32308	Recruiting
Research Site	West Palm Beach	Florida	33401	Recruiting
Research Site	Atlanta	Georgia	30318	Recruiting
Research Site	Atlanta	Georgia	30322	Recruiting
Research Site	Columbus	Georgia	31904	Recruiting
Research Site	Marietta	Georgia	30060	Recruiting
Research Site	Savannah	Georgia	31404	Recruiting
Research Site	Thomasville	Georgia	31792	Recruiting
Research Site	Chicago	Illinois	60637	Recruiting
Research Site	Elmhurst	Illinois	60126	Recruiting
Research Site	Naperville	Illinois	60540	Recruiting
Research Site	Park Ridge	Illinois	60068	Not yet recruiting
Research Site	Plainfield	Illinois	60585	Recruiting
Research Site	Urbana	Illinois	61801	Recruiting
Research Site	Fort Wayne	Indiana	46804	Recruiting
Research Site	Des Moines	Iowa	50309	Recruiting
Research Site	Fairway	Kansas	66205	Recruiting
Research Site	Louisville	Kentucky	40202	Recruiting
Research Site	New Orleans	Louisiana	70121	Recruiting
Research Site	Scarborough	Maine	04074	Recruiting
Research Site	Annapolis	Maryland	21401	Recruiting
Research Site	Baltimore	Maryland	21201	Not yet recruiting
Research Site	Baltimore	Maryland	21287	Not yet recruiting
Research Site	Bethesda	Maryland	20817	Recruiting
Research Site	Lutherville	Maryland	21093	Not yet recruiting
Research Site	Towson	Maryland	21204	Recruiting
Research Site	Boston	Massachusetts	02111	Recruiting
Research Site	Boston	Massachusetts	02115	Recruiting
Research Site	Hyannis	Massachusetts	02601	Not yet recruiting
Research Site	Worcester	Massachusetts	01655	Not yet recruiting
Research Site	Detroit	Michigan	48202	Recruiting
Research Site	Flint	Michigan	48503	Not yet recruiting
Research Site	Ypsilanti	Michigan	48197	Recruiting
Research Site	Minneapolis	Minnesota	55416	Recruiting
Research Site	Rochester	Minnesota	55905	Recruiting
Research Site	Kansas City	Missouri	64111	Recruiting
Research Site	St Louis	Missouri	63110	Recruiting
Research Site	St Louis	Missouri	63131	Recruiting
Research Site	Lincoln	Nebraska	68506	Recruiting
Research Site	Omaha	Nebraska	68124	Recruiting
Research Site	Omaha	Nebraska	68198	Withdrawn
Research Site	Hooksett	New Hampshire	03106	Recruiting
Research Site	Lebanon	New Hampshire	03756	Not yet recruiting
Research Site	Manchester	New Hampshire	03103	Recruiting
Research Site	New Brunswick	New Jersey	08901	Recruiting
Research Site	Albuquerque	New Mexico	87109	Recruiting
Research Site	Farmington	New Mexico	87401	Recruiting
Research Site	Bay Shore	New York	11706	Recruiting
Research Site	East Syracuse	New York	13057	Recruiting
Research Site	Greenlawn	New York	11740	Recruiting
Research Site	New Hyde Park	New York	11042	Recruiting
Research Site	New York	New York	10029	Recruiting
Research Site	New York	New York	10065	Recruiting
Research Site	Stony Brook	New York	11794	Recruiting
Research Site	White Plains	New York	10601	Recruiting
Research Site	Charlotte	North Carolina	28204	Recruiting
Research Site	Durham	North Carolina	27710	Not yet recruiting
Research Site	Greensboro	North Carolina	27403	Not yet recruiting
Research Site	Greenville	North Carolina	27834	Not yet recruiting
Research Site	Pinehurst	North Carolina	28374	Recruiting
Research Site	Raleigh	North Carolina	27607	Recruiting
Research Site	Winston-Salem	North Carolina	27103	Recruiting
Research Site	Blue Ash	Ohio	45242	Not yet recruiting
Research Site	Cincinnati	Ohio	45255	Recruiting
Research Site	Cleveland	Ohio	44106	Recruiting
Research Site	Columbus	Ohio	43212	Recruiting
Research Site	Toledo	Ohio	43623	Not yet recruiting
Research Site	Youngstown	Ohio	44504	Not yet recruiting
Research Site	Oklahoma City	Oklahoma	73104	Not yet recruiting
Research Site	Portland	Oregon	97210	Recruiting
Research Site	Portland	Oregon	97213	Recruiting
Research Site	Portland	Oregon	97225	Active, not recruiting
Research Site	Gettysburg	Pennsylvania	17325	Recruiting
Research Site	Hershey	Pennsylvania	17033	Recruiting
Research Site	Philadelphia	Pennsylvania	19104	Recruiting
Research Site	Pittsburgh	Pennsylvania	15213	Recruiting
Research Site	Sayre	Pennsylvania	18840	Recruiting
Research Site	York	Pennsylvania	17403	Recruiting
Research Site	Charleston	South Carolina	29425	Recruiting
Research Site	Greenville	South Carolina	29605	Recruiting
Research Site	Rock Hill	South Carolina	29732	Recruiting
Research Site	Spartanburg	South Carolina	29303	Recruiting
Research Site	Aberdeen	South Dakota	57401	Recruiting
Research Site	Sioux Falls	South Dakota	57105	Recruiting
Research Site	Chattanooga	Tennessee	37404	Not yet recruiting
Research Site	Knoxville	Tennessee	37909	Recruiting
Research Site	Knoxville	Tennessee	37920	Recruiting
Research Site	Memphis	Tennessee	38120	Recruiting
Research Site	Nashville	Tennessee	37203	Recruiting
Research Site	Nashville	Tennessee	37232	Recruiting
Research Site	Austin	Texas	78731	Recruiting
Research Site	Bedford	Texas	76022	Not yet recruiting
Research Site	Dallas	Texas	75230	Not yet recruiting
Research Site	Dallas	Texas	75231	Not yet recruiting
Research Site	Dallas	Texas	75246	Recruiting
Research Site	El Paso	Texas	79902	Recruiting
Research Site	Flower Mound	Texas	75028	Recruiting
Research Site	Houston	Texas	77024	Recruiting
Research Site	Houston	Texas	77030	Not yet recruiting
Research Site	Plano	Texas	75075	Not yet recruiting
Research Site	San Antonio	Texas	78217	Recruiting
Research Site	Tyler	Texas	75702	Recruiting
Research Site	Salt Lake City	Utah	84112	Not yet recruiting
Research Site	Charlottesville	Virginia	22908	Recruiting
Research Site	Fairfax	Virginia	22031	Recruiting
Research Site	Midlothian	Virginia	23114	Recruiting
Research Site	Norfolk	Virginia	23502	Recruiting
Research Site	Richmond	Virginia	23219	Not yet recruiting
Research Site	Roanoke	Virginia	24014	Recruiting
Research Site	Winchester	Virginia	22601	Recruiting
Research Site	Puyallup	Washington	98373	Recruiting
Research Site	Spokane	Washington	99202	Recruiting
Research Site	Vancouver	Washington	98684	Recruiting
Research Site	Charleston	West Virginia	25304	Not yet recruiting
Research Site	Morgantown	West Virginia	26505	Recruiting
Research Site	Appleton	Wisconsin	54911	Recruiting
Research Site	Madison	Wisconsin	53792	Recruiting
Research Site	Milwaukee	Wisconsin	53215	Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 641 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05952557, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jun 18, 2025 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05952557 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →