An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2)
Public ClinicalTrials.gov record NCT05952557. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
CAMBRIA-2: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) vs Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) as Adjuvant Treatment for Patients With ER+/HER2- Early Breast Cancer and an Intermediate-High or High Risk of Recurrence Who Have Completed Definitive Locoregional Treatment and Have No Evidence of Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard adjuvant endocrine therapy for patients with ER+/HER2- early breast cancer with intermediate-high or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy). The planned duration of treatment in either arm within the study will be 7 years.
Study identification
- NCT ID
- NCT05952557
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 5,511 participants
Conditions and interventions
Conditions
Interventions
- Camizestrant Drug
- Tamoxifen Drug
- Anastrozole Drug
- Letrozole Drug
- Exemestane Drug
- Abemaciclib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 4, 2023
- Primary completion
- Mar 3, 2030
- Completion
- May 5, 2037
- Last update posted
- Aug 9, 2026
2023 – 2037
United States locations
- U.S. sites
- 111
- U.S. states
- 37
- U.S. cities
- 101
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Dothan | Alabama | 36303 | — |
| Research Site | Phoenix | Arizona | 85054 | — |
| Research Site | Tucson | Arizona | 85745 | — |
| Research Site | Fayetteville | Arkansas | 72703 | — |
| Research Site | Duarte | California | 91010 | — |
| Research Site | Fountain Valley | California | 92708 | — |
| Research Site | Irvine | California | 92618 | — |
| Research Site | La Jolla | California | 92093 | — |
| Research Site | Los Angeles | California | 90017 | — |
| Research Site | Walnut Creek | California | 94598 | — |
| Research Site | West Hollywood | California | 90048 | — |
| Research Site | Aurora | Colorado | 80045 | — |
| Research Site | Littleton | Colorado | 80120 | — |
| Research Site | Littleton | Colorado | 80129 | — |
| Research Site | New Haven | Connecticut | 06510 | — |
| Research Site | Newark | Delaware | 19713 | — |
| Research Site | Clearwater | Florida | 33756 | — |
| Research Site | Fort Myers | Florida | 33901 | — |
| Research Site | Gainesville | Florida | 32610 | — |
| Research Site | Jacksonville | Florida | 32224 | — |
| Research Site | Pembroke Pines | Florida | 33028 | — |
| Research Site | Plantation | Florida | 33322 | — |
| Research Site | Plantation | Florida | 33324 | — |
| Research Site | St. Petersburg | Florida | 33705 | — |
| Research Site | St. Petersburg | Florida | 33709 | — |
| Research Site | Tallahassee | Florida | 32308 | — |
| Research Site | West Palm Beach | Florida | 33401 | — |
| Research Site | Atlanta | Georgia | 30318 | — |
| Research Site | Marietta | Georgia | 30060 | — |
| Research Site | Thomasville | Georgia | 31792 | — |
| Research Site | Chicago | Illinois | 60637 | — |
| Research Site | Elmhurst | Illinois | 60126 | — |
| Research Site | Naperville | Illinois | 60540 | — |
| Research Site | Urbana | Illinois | 61801 | — |
| Research Site | Fort Wayne | Indiana | 46804 | — |
| Research Site | Des Moines | Iowa | 50309 | — |
| Research Site | Louisville | Kentucky | 40202 | — |
| Research Site | New Orleans | Louisiana | 70121 | — |
| Research Site | Scarborough | Maine | 04074 | — |
| Research Site | Annapolis | Maryland | 21401 | — |
| Research Site | Bethesda | Maryland | 20817 | — |
| Research Site | Towson | Maryland | 21204 | — |
| Research Site | Boston | Massachusetts | 02111 | — |
| Research Site | Boston | Massachusetts | 02115 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Ypsilanti | Michigan | 48197 | — |
| Research Site | Minneapolis | Minnesota | 55416 | — |
| Research Site | Rochester | Minnesota | 55905 | — |
| Research Site | Kansas City | Missouri | 64111 | — |
| Research Site | St Louis | Missouri | 63110 | — |
| Research Site | St Louis | Missouri | 63131 | — |
| Research Site | Lincoln | Nebraska | 68506 | — |
| Research Site | Omaha | Nebraska | 68124 | — |
| Research Site | Hooksett | New Hampshire | 03106 | — |
| Research Site | Manchester | New Hampshire | 03103 | — |
| Research Site | New Brunswick | New Jersey | 08901 | — |
| Research Site | Albuquerque | New Mexico | 87109 | — |
| Research Site | Farmington | New Mexico | 87401 | — |
| Research Site | Bay Shore | New York | 11706 | — |
| Research Site | East Syracuse | New York | 13057 | — |
| Research Site | Greenlawn | New York | 11740 | — |
| Research Site | New Hyde Park | New York | 11042 | — |
| Research Site | New York | New York | 10029 | — |
| Research Site | New York | New York | 10065 | — |
| Research Site | Stony Brook | New York | 11794 | — |
| Research Site | White Plains | New York | 10601 | — |
| Research Site | Charlotte | North Carolina | 28204 | — |
| Research Site | Pinehurst | North Carolina | 28374 | — |
| Research Site | Raleigh | North Carolina | 27607 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Cincinnati | Ohio | 45255 | — |
| Research Site | Cleveland | Ohio | 44106 | — |
| Research Site | Columbus | Ohio | 43212 | — |
| Research Site | Portland | Oregon | 97210 | — |
| Research Site | Portland | Oregon | 97213 | — |
| Research Site | Portland | Oregon | 97225 | — |
| Research Site | Gettysburg | Pennsylvania | 17325 | — |
| Research Site | Hershey | Pennsylvania | 17033 | — |
| Research Site | Philadelphia | Pennsylvania | 19104 | — |
| Research Site | Pittsburgh | Pennsylvania | 15213 | — |
| Research Site | Sayre | Pennsylvania | 18840 | — |
| Research Site | York | Pennsylvania | 17403 | — |
| Research Site | Charleston | South Carolina | 29425 | — |
| Research Site | Rock Hill | South Carolina | 29732 | — |
| Research Site | Spartanburg | South Carolina | 29303 | — |
| Research Site | Aberdeen | South Dakota | 57401 | — |
| Research Site | Sioux Falls | South Dakota | 57105 | — |
| Research Site | Knoxville | Tennessee | 37909 | — |
| Research Site | Knoxville | Tennessee | 37920 | — |
| Research Site | Memphis | Tennessee | 38120 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Nashville | Tennessee | 37232 | — |
| Research Site | Austin | Texas | 78731 | — |
| Research Site | Dallas | Texas | 75246 | — |
| Research Site | El Paso | Texas | 79902 | — |
| Research Site | Flower Mound | Texas | 75028 | — |
| Research Site | Houston | Texas | 77024 | — |
| Research Site | San Antonio | Texas | 78217 | — |
| Research Site | Tyler | Texas | 75702 | — |
| Research Site | Charlottesville | Virginia | 22908 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Midlothian | Virginia | 23114 | — |
| Research Site | Norfolk | Virginia | 23502 | — |
| Research Site | Roanoke | Virginia | 24014 | — |
| Research Site | Winchester | Virginia | 22601 | — |
| Research Site | Puyallup | Washington | 98373 | — |
| Research Site | Spokane | Washington | 99202 | — |
| Research Site | Vancouver | Washington | 98684 | — |
| Research Site | Morgantown | West Virginia | 26505 | — |
| Research Site | Appleton | Wisconsin | 54911 | — |
| Research Site | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 550 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05952557, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 9, 2026 · Synced Sep 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05952557 live on ClinicalTrials.gov.